A5086705545- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced NMR Techniques and Applications
- Catalytic Processes in Materials Science
- Catalysis and Oxidation Reactions
- Solid-state spectroscopy and crystallography
- Zeolite Catalysis and Synthesis
- NMR spectroscopy and applications
- Mesoporous Materials and Catalysis
- Muon and positron interactions and applications
- Glass properties and applications
- Oxidative Organic Chemistry Reactions
- Soil Carbon and Nitrogen Dynamics
- Metal-Organic Frameworks: Synthesis and Applications
- Cassava research and cyanide
- Phytase and its Applications
- Fluorine in Organic Chemistry
- Alzheimer's disease research and treatments
- Crystallography and molecular interactions
- Catalysts for Methane Reforming
- Atomic and Subatomic Physics Research
- Advanced Condensed Matter Physics
- Catalysis and Hydrodesulfurization Studies
- Perovskite Materials and Applications
- Heavy metals in environment
ETH Zurich
2016-2025
Board of the Swiss Federal Institutes of Technology
2008-2024
Bioengineering (Switzerland)
2019-2023
Charles Humbert 8
2016-2020
Radboud University Nijmegen
1997-1998
Institute of Chemistry
1997
University of Liverpool
1997
Abstract Methanol synthesis by CO 2 hydrogenation is a key process in methanol‐based economy. This reaction catalyzed supported copper nanoparticles and displays strong support or promoter effects. Zirconia known to enhance both the methanol production rate selectivity. Nevertheless, origin of this observation mechanisms associated with conversion still remain unknown. A mechanistic study on Cu/ZrO presented. Using kinetics, situ IR NMR spectroscopies, isotopic labeling strategies, surface...
The aggregation of proteins into amyloid fibrils is associated with several neurodegenerative diseases. In Parkinson's disease it believed that the α-synuclein (α-syn) from monomers by intermediates toxic disease-causative mechanism. Here, we studied structure α-syn in its state using various biophysical approaches. Quenched hydrogen/deuterium exchange NMR spectroscopy identified five β-strands within fibril core comprising residues 35–96 and solid-state data 30–110 confirmed presence...
Adding a new dimension: 4D or 3D proton-detected spectra of perdeuterated protein samples with 1H labelled amides and methyl groups permit collecting unambiguous distance restraints high sensitivity determining structure by solid-state NMR (see picture). Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited typeset. They made available submitted the authors. Please note: The publisher is responsible for...
The sequence-specific resonance assignment of a protein forms the basis for studies molecular structure and dynamics, as well to functional assay by NMR spectroscopy. Here we present protocol sequential 13C 15N uniformly [15N,13C]-labeled proteins, based on suite complementary three-dimensional solid-state spectroscopy experiments. It is directed towards application proteins with more than about 100 amino acid residues. assignments rely walk along backbone using combination three experiments...
The properties of silica aerogels, and the ability to prepare them by ambient pressure drying, hinge on their chemical surface modification. Until now, quantitative analysis chemistry has not been possible state-of-the-art analytical methods. Here, we determine six archetypal, dried, hydrophobic aerogels open-porous foams with 1H, 13C, 29Si 1H–29Si heteronuclear solid-state NMR spectroscopy. quality external calibration, validation elemental analysis, consistency among MAS data enable us...
Effective CF3 transfer: Various electron-rich nitrogen heterocycles (pyrazoles, triazoles, and tetrazoles) can be directly N-trifluoromethylated by a hypervalent iodine reagent in an efficient manner. The optimized procedure, which includes situ silylation of the substrate followed acid-catalyzed transfer, provides ready access to series new previously challenging or inaccessible NCF3 compounds.
Abstract The vast structural and chemical diversity of metal−organic frameworks (MOFs) provides the exciting possibility material’s design with tailored properties for gas separation, storage catalysis. However, after more than twenty years first reports introducing MOFs, discovery control their synthesis remains extremely challenging due to lack understanding mechanisms nucleation growth. Progress in deciphering crystallization pathways depends on follow conversion initial reagents products...
Zeolites, although key materials used in industrial processes, remain poorly understood on a molecular level despite their well-defined crystal lattices. In fact, obtaining direct spectroscopic signatures and resolving the structure of Lewis acid sites (LAS) has remained challenge. this work, thanks to 1D 2D 1H, 15N, 27Al MAS NMR spectroscopy, carried out at different temperatures (from 298 down 107 K), we were able obtain LAS Brønsted (BAS) mordenite zeolite presence absence adsorbed...
The catalytic performance of supported metal oxides is often controlled by their two- or three-dimensional dispersion. Silica, one the popular inert supports, triggers undesired formation nanoparticles at significantly lower loadings than other conventional supports like Al2O3, TiO2, Nb2O5, ZrO2. This observation has been ascribed to reactivity surface SiOH groups toward precursor, compared hydroxyl on different supports. In this contribution, we show that promoting amorphous silica with low...
Abstract The reaction of methane with copper‐exchanged mordenite two different Si/Al ratios was studied by means in situ NMR and infrared spectroscopies. detection signals shown to be possible high sensitivity resolution, despite the presence a considerable number paramagnetic Cu II species. Several types surface‐bonded compounds were found after reaction, namely molecular methanol, methoxy species, dimethyl ether, mono‐ bidentate formates, I monocarbonyl as well carbon monoxide dioxide,...
Abstract Understanding the structure and dynamics of newcomer optoelectronic materials - lead halide perovskites APbX 3 [A = Cs, methylammonium (CH NH + , MA), formamidinium (CH(NH 2 ) FA); X Cl, Br, I] has been a major research thrust. In this work, new insights could be gained by using 207 Pb solid-state nuclear magnetic resonance (NMR) spectroscopy at variable temperatures between 100 300 K. The existence scalar couplings 1 J Pb-Cl ca . 400 Hz Pb-Br 2.3 kHz confirmed for MAPbX CsPbX...
Lead-halide perovskites increasingly mesmerize researchers because they exhibit a high degree of structural defects and dynamics yet nonetheless offer an outstanding (opto)electronic performance on par with the best examples structurally stable defect-free semiconductors. This highly unusual feature necessitates adoption experimental theoretical mindset reexamination techniques that may be uniquely suited to understand these materials. Surprisingly, suite methods for characterization...
Zirconium-containing metal-organic framework (MOF) with UiO-66 topology is an extremely versatile material, which finds applications beyond gas separation and catalysis. However, after more than 10 years the first reports introducing this MOF, understanding of molecular-level mechanism its nucleation growth still lacking. By means in situ time-resolved high-resolution mass spectrometry, Zr K-edge X-ray absorption spectroscopy, magic-angle spinning nuclear magnetic resonance diffraction it...
Copper(II)-containing mordenite (CuMOR) is capable of activation C-H bonds in C1 -C3 alkanes, albeit there are remarkable differences between the functionalization ethane and propane compared to methane. The reaction with CuMOR results formation ethylene propylene, while methane predominantly yields methanol dimethyl ether. By combining situ FTIR MAS NMR spectroscopies as well time-resolved Cu K-edge X-ray absorption spectroscopy, mechanism was derived, which differs significantly for each...
The aqueous-phase heterogeneously catalysed isomerisation of bio-oil derived glyoxal is herein introduced as a novel route for the sustainable production glycolic acid. While commercial ultra-stable Y zeolites displayed only moderate performance, their evaluation enabled us to highlight crucial role Lewis acidity in reaction. Gallium incorporation into these boosted acid yield, although best catalytic results were obtained over tin-containing MFI-type zeolites, reaching 91% yield desired...
HHDMA-modified Pd catalysts exhibit enhanced activity in the hydrogenation of alkynes, nitriles, and carbonyls with increasing HHDMA coverage due to different conformations adopted by ligand.
Abstract Methanol synthesis by CO 2 hydrogenation is a key process in methanol‐based economy. This reaction catalyzed supported copper nanoparticles and displays strong support or promoter effects. Zirconia known to enhance both the methanol production rate selectivity. Nevertheless, origin of this observation mechanisms associated with conversion still remain unknown. A mechanistic study on Cu/ZrO presented. Using kinetics, situ IR NMR spectroscopies, isotopic labeling strategies, surface...
Re2O7 supported on γ-alumina is an alkene metathesis catalyst active at room temperature, compatible with functional groups, but the exact structures of sites are unknown. Using CH3ReO3/Al2O3 as a model for Re2O7/Al2O3, we show through combination reactivity studies, in situ solid-state NMR, and extensive series DFT calculations, that μ-methylene (Al-CH2-ReO3-Al) containing Re═O bound to tricoordinated Al (AlIII) CH2 four-coordinated (AlIVb) precursors most olefin metathesis. The resting...