A5103002200- Cancer Treatment and Pharmacology
- Fluid Dynamics and Turbulent Flows
- Computational Fluid Dynamics and Aerodynamics
- Cancer therapeutics and mechanisms
- Metabolism and Genetic Disorders
- Gas Dynamics and Kinetic Theory
- Muscle metabolism and nutrition
- Colorectal Cancer Treatments and Studies
- Microtubule and mitosis dynamics
- Metal complexes synthesis and properties
- Microbial Natural Products and Biosynthesis
- Cardiovascular Health and Disease Prevention
- Synthetic Organic Chemistry Methods
- Various Chemistry Research Topics
- HER2/EGFR in Cancer Research
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Particle Dynamics in Fluid Flows
- Blood Pressure and Hypertension Studies
- Child and Adolescent Health
- Plasma and Flow Control in Aerodynamics
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
Quantitative BioSciences
2023
University of Delaware
2011-2023
University of Chicago
2021
Sierra Nevada College
1979-2011
Christiana Care Health System
2007-2011
South College
2010
University of Illinois Urbana-Champaign
1949-2009
Bristol-Myers Squibb (United States)
1999-2009
Endocyte (United States)
2008
Research Triangle Park Foundation
2007
In a series of papers extending over many years evidence has been presented regarding the nutritive r&e each recognized components proteins.The results have demonstrated that ten amino acids are essential dietary for rat.The exclusion from food any one these, other than arginine, leads to profound failure, loss in weight, and eventual death.Arginine differs several respects constituents proteins.First, it can be synthesized by rat (l), but not at rate commensurate with needs organism maximum...
Two cytotoxic rocaglate derivatives possessing an unusual dioxanyloxy unit, silvestrol (1) and episilvestrol (2), were isolated from the fruits twigs of Aglaia silvestris by bioassay-guided fractionation monitored with a human oral epidermoid carcinoma (KB) cell line. Additionally, two new baccharane-type triterpenoids, 17,24-epoxy-25-hydroxybaccharan-3-one (3) 17,24-epoxy-25-hydroxy-3-oxobaccharan-21-oic acid (4), as well eleven known compounds, 1β,6α-dihydroxy-4(15)-eudesmene (5), ferulic...
1. We sought to distinguish two types of Ca2+ channel in guinea‐pig ventricular cells (T‐type and L‐type) characterize their respective gating permeation properties when (1‐10 mM) is the charge carrier, as case physiologically. 2. Na+ was removed from both external internal solutions eliminate currents through channels Na(+)‐Ca2+ exchange. Major differences voltage dependence steady‐state inactivation were exploited separate current components. 3. From a holding potential ‐50 mV, only L‐type...
Recent animal studies have reported that exercise pressor reflex (EPR)-mediated increases in blood pressure are exaggerated hypertensive (HTN) rodents. Whether these findings can be extended to human hypertension remains unclear. Mean arterial (MAP), muscle sympathetic nerve activity (MSNA), and venous metabolites were measured normotensive (NTN; n = 23; 60 ± 1 yr) HTN (n 15; 63 subjects at baseline, during static handgrip 30 40% maximal voluntary contraction (MVC) followed by a period of...
Earlier papers of this series (1, 2) have demonstrated (a) that the ten amino acids previously found to be dispensable dietary components for growing rat (3) and adult dog (4) are also man, (b) valine, methionine, threonine essential constituents food human subjects, (c) histidine, contrary expectations, is not necessary maintenance nitrogen balance, nor preservation a sense physical well being in adults.The absence objective subjective symptoms following exclusion histidine from diet...
The hitherto unknown growth essential has been isolated in pure, crystalline form, san indentified as one of the four optically isomeric α-amino-β-hydroxy-n-butyric acids. Several its derivatives have prepared and described. On reduction new amino acid yields d-α-amino-n-butyrie acid. spatial configuration around β-carbon atom remians to be determined, is now being investigated. With an otherwise adequate diet, appromiately 0.6 per cent α-amino-β-hydroxybutyric minimum amount necessary...