A5070874315- Maternal Mental Health During Pregnancy and Postpartum
- Birth, Development, and Health
- Racial and Ethnic Identity Research
- Child and Adolescent Psychosocial and Emotional Development
- Migration, Health and Trauma
- Child and Adolescent Health
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Genomics and Rare Diseases
- Evolutionary Psychology and Human Behavior
- Immunodeficiency and Autoimmune Disorders
- Health disparities and outcomes
- Work-Family Balance Challenges
- Nutrition, Genetics, and Disease
- BRCA gene mutations in cancer
- Intergenerational Family Dynamics and Caregiving
- Infant Development and Preterm Care
- Neuroendocrine regulation and behavior
- Family Support in Illness
University of North Carolina at Chapel Hill
2020-2024
National Institute of Nursing Research
2024
Worcester Polytechnic Institute
2022
As the master regulator in utero, placenta is core to Developmental Origins of Health and Disease (DOHaD) hypothesis but historically understudied. To identify placental gene-trait associations (GTAs) across life course, we perform distal mediator-enriched transcriptome-wide association studies (TWAS) for 40 traits, integrating multi-omics from Extremely Low Gestational Age Newborn Study. At [Formula: see text], detect 248 GTAs, mostly neonatal metabolic 176 genes, enriched cell growth...
BACKGROUND: Discrimination, or unfair treatment based on individual characteristics such as gender, race, skin color, and sexual orientation, is a pervasive social stressor that perpetuates health disparities by limiting economic opportunity associated with poor mental physical outcomes. AIMS: The purpose of the present study to (1) examine association between maternal experiences discrimination paternal discrimination; (2) explore how relates parental (maternal paternal) stress depressive...
Abstract Although immigrant mothers from some Latinx subgroups initially achieve healthy birth outcomes despite lower socioeconomic status, this advantage deteriorates across generations in the United States. Interpersonal discrimination and acculturative stress may interact with economic hardship to predict an intergenerational cascade of emotional biological vulnerabilities, particularly perinatal depression. Network analyses elucidate not only how which psychosocial experiences relate...
Latinas in the United States suffer disproportionately high levels of pre- and postnatal depression. However, little is understood regarding biopsychosocial mechanisms linking socio-environmental factors to this increase mental health risk. The oxytocinergic system, with its roles stress response, social behaviour mood regulation, may be an important modulator sensitivity. We have previously reported prenatal discrimination a significant predictor depression Latinas; here we tested whether...
Abstract Objective Immigrant Latinas, particularly of Mexican descent, initially achieve healthy perinatal outcomes. Although this advantage wears off across generations in the United States (US), early life psychosocial mechanisms that may initiate a cascade biological vulnerabilities remain elusive. The current investigation aims to understand extent which childhood experiences racism contribute elevated levels C-Reactive Protein (CRP), an indicator cardiometabolic risk, during first...
ABSTRACT As the master regulator in utero , placenta is core to Developmental Origins of Health and Disease (DOHaD) hypothesis but historically understudied. To identify placental gene-trait associations (GTAs) across life course, we performed distal mediator-enriched transcriptome-wide association studies (TWAS) for 40 traits, integrating multi-omics from Extremely Low Gestational Age Newborn Study. At P < 2.5 × 10 −6 detected 248 GTAs, mostly neonatal metabolic 176 genes, enriched cell...