A5022134651- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Caveolin-1 and cellular processes
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Gastric Cancer Management and Outcomes
- Phagocytosis and Immune Regulation
- Cancer Mechanisms and Therapy
- Estrogen and related hormone effects
- Glioma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Cell death mechanisms and regulation
- Cutaneous Melanoma Detection and Management
- Natural Compounds in Disease Treatment
- Immunotherapy and Immune Responses
Klinikum rechts der Isar
2017-2020
Technical University of Munich
2017-2020
University of Miami
2016-2018
Sylvester Comprehensive Cancer Center
2016-2018
University of Minnesota
2013-2017
University of Minnesota System
2017
University of Wisconsin–Madison
2012-2013
Institute for Medical Informatics and Biostatistics
2013
University of Hawaii System
1989
// Alice Nomura 1 , Sulagna Banerjee Rohit Chugh Vikas Dudeja Masato Yamamoto Selwyn M. Vickers Ashok K. Saluja Division of Basic and Translational Research, Department Surgery, University Minnesota, Minneapolis, MN, USA Correspondence to: Saluja, e-mail: asaluja@umn.edu Keywords: CD133, pancreatic cancer, invasion, metastasis, NF-kB Received: October 28, 2014 Accepted: January 27, 2015 Published: March 16, 2015 ABSTRACT CD133 has...
Abstract Purpose: Pancreatic adenocarcinoma is the fourth leading cause for cancer-related mortality with a survival rate of less than 5%. Late diagnosis and lack effective chemotherapeutic regimen contribute to these grim statistics. Relapse any tumor largely attributed presence tumor-initiating cells (TIC) or cancer stem (CSC). These are considered as hurdles therapy no known compound reported target them. Thus, there an urgent need develop TIC-targeted pancreatic cancer. Experimental...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibroblast-rich desmoplastic stroma. Cancer-associated fibroblasts (CAFs) have been shown to display high degree of interconvertible states including quiescent, inflammatory, and myofibroblastic phenotypes; however, the mechanisms which this plasticity achieved are poorly understood. Here, we aim elucidate role CAF its impact on PDAC biology.To investigate mesenchymal in progression, generated mouse model modulated genetic...
Chemoresistance in pancreatic cancer has been attributed to tumor-initiating cells (TICs), a minor sub-population of tumor cells. However, the mechanism chemo-resistance these is still unclear.In current study, immunohistochemical analysis LSL-KrasG12D; LSL-Trp53R172H;PdxCre (KPC) murine tumors indicated that hypoxic regions developed through progression. This "niche" correlated with increased CD133+ population had an HIF1A activity. Consistent this observation, glucose uptake and activity...
Abstract Tumor-initiating cells (TIC) have been implicated in pancreatic tumor initiation, progression, and metastasis. Among different markers that define this cell population within the tumor, CD133+ cancer stem (CSC) has reliably described these processes. CD133 expression also shown to functionally promote metastasis through NF-κB activation population, but mechanism is unclear. In current study, overexpression of increased secretion IL1β (IL1B), which activates an autocrine signaling...
Pancreatic tumors are renowned for their extremely hypoxic centers, resulting in upregulation of a number hypoxia mediated signaling pathways including cell proliferation, metabolism and survival. Previous studies from our laboratory have shown that Minnelide, water-soluble pro-drug triptolide (anti-cancer compound), decreases viability cancer cells vitro as well vivo. However, its mechanism action remain elusive. In the current study we evaluated effect on oncogenic stemness pancreatic...
Chemoresistance is a major therapeutic challenge that plays role in the poor statistical outcomes pancreatic cancer. Unfolded protein response ( UPR ) one of homeostasis mechanisms cancer cells have been correlated with chemoresistance number cancers including In this study, we show modulating glucose regulatory 78 GRP 78), master regulator , can profound effect on multiple pathways mediate chemoresistance. Our study showed for first time silencing diminish efflux activity ATP ‐binding...
Journal Article SMOKING, ALCOHOL, OCCUPATION, AND HAIR DYE USE IN CANCER OF THE LOWER URINARY TRACT Get access ABRAHAM NOMURA, NOMURA Search for other works by this author on: Oxford Academic PubMed Google Scholar LAURENCE N. KOLONEL, KOLONEL CARL YOSHIZAWA American of Epidemiology, Volume 130, Issue 6, December 1989, Pages 1159–1163, https://doi.org/10.1093/oxfordjournals.aje.a115443 Published: 01 1989 history Received: May
Rb1 is the most frequently mutated gene in pediatric cancer retinoblastoma, and its loss causes E2F transcription factors to induce proliferation related genes. However, high levels following pRB also apoptosis-promoting genes as a safeguard mechanism suppress emergent tumors. Although p53 accumulation apoptosis induction believed be primary eliminate cells with excess activity, deletion doesn't RB/E2F induced vivo retina. This prompted us test PTEN/PI3K/AKT signaling pathway on suppression...
Abstract Endoplasmic reticulum (ER) stress initiates an important mechanism for cell adaptation and survival, named the unfolded protein response (UPR). Severe or chronic/prolonged UPR can breach threshold survival lead to death. There is a fundamental gap in knowledge on molecular of how chronic ER stimulated leads death pancreatic ductal adenocarcinoma (PDAC). Our study shows that downregulating specificity 1 (Sp1), transcription factor overexpressed cancer, activates results stress. In...
Pancreatic Ductal Adenocarcinoma (PDAC) is a devastating disease hallmarked by limited patient survival. Resistance to chemotherapy, major cause of treatment failure in PDAC patients, often attributed Cancer Stem Cells (CSCs). CSCs are small subset quiescent cells within tumor represented surface markers like CD133. These responsible not only for recurrence, but also poor prognosis based on their "stem-like" characteristics. At present, conventional therapy directed towards rapidly dividing...
Abstract Colorectal cancer often arises from adenomatous colonic polyps. Polyps can grow and progress to cancer, but may also remain static in size, regress, or resolve. Predicting which polyps benign is difficult. We developed a novel long-lived murine model of colorectal with tumors that be followed by colonoscopy. Our aim was assess whether these have similar growth patterns histologic fates human identify features aid risk stratification tumors. Long-lived ApcMin/+ mice were treated...
We have previously developed a model that provides relative dosimetry estimates for targeted radionuclide therapy (TRT) agents. The whole-body and tumor pharmacokinetic (PK) parameters of this can be noninvasively measured with molecular imaging, providing means comparing potential TRT Parameter sensitivities noise will affect the accuracy precision estimated PK values hence estimates. aim work is to apply two agents different magnitudes clearance rates, NM404 FLT, explore parameter...
Abstract CD133 has been implicated as a cancer stem cell (CSC) surface marker in several malignancies including pancreatic cancer, however, the functional role remains elusive. In this study, we overexpressed CSC line with minimal endogenous order to determine its within context. We determined that expression led increased tumorigenicity down 10 cells. Progression of tumors derived from cells overexpressing volume quicker than controls. Additionally, number lesions and sites metastasis were...
The digital dermal patterns of 149 patients with large-bowel cancer and 298 population-based controls were studied. very similar between the 2 groups. Also, no significant differences found in total ridge counts, which suggests that antenatal factors, related to formation patterns, are not associated risk cancer.
Abstract Background: Pancreatic ductal adenocarcinoma is currently the fourth most frequent cause of cancer-related death in United States with poor survival. Tumor recurrence this devastating disease adds to its grim Relapse any tumor largely attributed presence tumor-initiating cells (TIC). Chemo-resistance considered a hallmark TICs. Standard chemotherapy typically targets rapidly growing as result which quiescent TICs often evade cell by these agents. However, mechanism involved...