A5102941900- Synthesis and bioactivity of alkaloids
- Biochemical effects in animals
- Pharmacogenetics and Drug Metabolism
- Cancer therapeutics and mechanisms
- Synthesis and pharmacology of benzodiazepine derivatives
- Pharmacological Effects of Natural Compounds
- Synthesis and Biological Evaluation
- Aldose Reductase and Taurine
- Chemical synthesis and alkaloids
- Medicinal Plants and Bioactive Compounds
- Cancer Treatment and Pharmacology
- Free Radicals and Antioxidants
Sechenov University
2020-2023
В статье обсуждаются результаты исследования антидепрессивного действия водорастворимой формы гидрохлорида гармина
We have used an original chromatography/mass spectrometry technique to study the pharmacokinetics of dipeptide carnosine in C57 Black/6 mice after intraperitoneal administration drug at a dose 1 g/kg. The basic pharmacokinetic characteristics were measured blood and brain. obtained concentration – time curve has biexponential character. It is shown that maximum plasma C max = 1081.75 ± 124.24 μg/mL it achieved interval T 0.25 h. showed i.p. exogenous could significantly increase substance...
The experimental study of the pharmacokinetic characteristics a new pyrrole derivative carnosine, pyrrolylcarnosine, was carried out. Based on results experiment, basic parameters drug are expected. tissues and organs bioavailability studied. tropism pyrrolylcarnosine to elimination ability penetrate into heart muscle tissue were shown.
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An experimental comparative study of the relative bioavailability plant alkaloid harmine (native, in form a base) comparison with its derivative hydrochloride was carried out on chinchilla rabbit. Both substances administered capsules, containing an equimolar amount (50 mg, p.o.). Harmin shown to have some pharmacokinetic advantages native harmin due relatively rapid achievement maximal plasma concentration (T max ) and significantly higher maximum active substance blood. At same time, there...
A derivative of the beta-carboline alkaloid harmine — drug hydrochloride was studied for presence antihypoxic properties in models hypobaric hypoxia and normobaric with hypercapnia. It found that does not have a signifi cant compensatory effect test At same time, small doses (2.5 5 mg/kg) has activity test, which is expressed statistically increase life expectancy animals treated drug, compared control, conditions hypoxia. According to effect, at 2.5 mg/kg be comparable reference (mexidol,...