A5054251365- Synthesis and bioactivity of alkaloids
- Synthesis and Biological Evaluation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical synthesis and alkaloids
- Analytical Chemistry and Chromatography
- Botanical Research and Chemistry
- Synthesis and pharmacology of benzodiazepine derivatives
- Synthesis and biological activity
- Chromatography in Natural Products
- Synthesis and Characterization of Heterocyclic Compounds
- Pharmacological Effects of Natural Compounds
- Cancer therapeutics and mechanisms
- Chemical Thermodynamics and Molecular Structure
- Synthesis of Organic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis and Reactions of Organic Compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Drug Solubulity and Delivery Systems
- Scientific Research and Studies
- Medical and Pharmaceutic Studies
- Enzyme Catalysis and Immobilization
- Bioactive Compounds and Antitumor Agents
- Psychedelics and Drug Studies
- Agriculture and Biological Studies
Ministry of Education and Science of the Republic of Kazakhstan
2019-2025
Karaganda Medical University
2020-2024
Institute of Organic Synthesis
2024
Karagandy State University
2011
In this study, the synthesis and properties of β-cyclodextrin-functionalized silver nanoparticles their loading with a drug component are considered. β-Cyclodextrin was used as reducing agent stabilizer in preparation nanoparticles. The use β-CD-AgNPs molecules alkaloid cytisine (Cz) its O,O-dimethyl-N-cytisinilphosphate (CzP) derivative, which have pronounced antiviral properties, studied. formation β-CD-Cz-AgNPs β-CD-CzP-AgNPs confirmed by UV spectroscopy X-ray diffraction spectroscopy....
Бас редактор: ЖҰРЫНОВ Мұрат Жұрынұлы, химия ғылымдарының докторы, профессор, ҚР ҰҒА академигі, Қазақстан Республикасы Ұлттық ғылым академиясының президенті, АҚ «Д.В.Сокольский атындағы отын, катализ және электрохимия институтының» бас директоры (
The article presents results on the synthesis and investigation of structural features a number 1,4-disubstituted 1H-1,2,3-triazole derivatives alkaloid lupinine. Lupinine modification reactions have been carried out at hydroxymethylene group in C-1 position quinolysine backbone. It has shown that (octahydro-2H-quinolysine-1-ylmethyl)methanesulfonate high yield (93%) is formed by in-teraction lupinine with methanesulfonyl chloride methylene chloride. Subsequent treatment this com-pound...
This article presents results of histochemical analysis aerial and underground organs Anabasis salsa (C. A. Mey.) Benth. ex Volkens growing in the Central Kazakhstan. The localization active substances medicinal raw materials was determined using reactions.Presence essential oil, alkaloids, sesquiterpene lactones, flavonoids, phenolic compounds, polysaccharides plant (shoots, inflorescences roots) established. species is used traditional medicine as a diuretic, antispasmodic, analgesic, also...
The reactions of lupinine alkaloid and its chlorine derivative with cinnamoyl chloride 2-K-isoindole-1,3-dione were investigated to obtain 3-phenylacrylic acid octahydroquinolizin-1-ylmethyl ester 2-(octahydroquinolizin-1-ylmethyl)isoindole-1,3-dione, respectively. optimal conditions for carrying out the aforementioned determined, taking into account nature solvent medium. It was established that acylation molecule in a benzene medium, presence trimethylamine, resulted formation ester, an...
The article presents the results of a study amination reaction nicotinic acid chlorohydride with amines morpholine, cytisine, and 1-aminoadamantane, which are often used in search creation drugs for respiratory circulatory stimulants. was conducted to new biologically active compounds anti-inflammatory activity. synthesis aminoamides carried out by interaction molecules adamantane anhydrous ethanol. As result studies, amides high yields (90.7–93.1%) were obtained. structures determined using...
Influenza is a disease of significant morbidity and mortality. The number anti-influenza drugs small; many them stimulate the appearance resistant strains. This article presents results assessing antiviral activity 1,2,3-triazole-containing derivatives alkaloid lupinine for their ability to suppress reproduction orthomyxoviruses (influenza viruses: A/Vladivostok/2/09 (H1N1) A/Almaty/8/98 (H3N2)). (1
This work presents the results of studies on chemical transformation alkaloids moleculescytisine and anabazine to obtain their N-cinnamoyl derivatives, as well possible ways for furthermodification. The optimal conditions preparation N-cinnamoylcytisine N-cinnamoylanabazine in theacylation reactions with cinnamoyl chloride are considered. Hydrazinolysis resulting Ncinnamoylcytisine was carried out. It shown that interaction acrylamidederivatives hydrazine hydrate ethanol leads formation...
В статье обсуждаются результаты исследования антидепрессивного действия водорастворимой формы гидрохлорида гармина
Abstract Title compounds [(VI), (VIII), and (X)] are synthesized starting from harmine (I) via quaternized derivatives (V).
The modification of the quinolysin alkaloid lupinine was carried out with intro-duction 1,2,3-triazolyl substituents for hydroxymethylene group in C-1 position backbone. reaction methanesulfochloride presence triethylamine smoothly led to methanesulfonate, whose further sodium azide DMFA lupinilazide. 1,3-Dipolar [4+2]-cycloaddition resulting alkynes produced more stable 1,2,3-triazole compounds. interaction lupinilazide 2-ethinylpyridine and alcohols containing a terminal acetylene...
The indole alkaloid harmine was extracted from underground part of <em>Peganum harmala L.</em> With the purpose obtaining new biological active derivatives on base chemical modification carried out. p-toluolsulfochlorid, p-toluolsulfoacid, hydrochloric, sulfuric, nitric acids, dioxide selenium and phthalic anhydride have been chosen as modifiers. For first time quaternary ammonium salts, N-oxide N (2)-oxyharminiumphthalate are synthesized. structure synthesized compounds is...
This article represents the results of technological researches on development new neurotropic remedy based water-soluble excipient harmine hydrochloride. Peroral in capsules at dose 30 mg which correspond to pharmaceutical quality indices have been developed for first time.
Синтезированы N-оксиды гармина и глауцина. Изучено влияние полученных соединений исходных алкалоидов на фагоцитоз моноцитов крови человека in vitro. Выявлены выраженные фагоцитоз-стимулирующие свойства N-оксидов