A5004626554- Meningioma and schwannoma management
- Immunotherapy and Immune Responses
- Synthesis and bioactivity of alkaloids
- RNA Interference and Gene Delivery
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Glioma Diagnosis and Treatment
- Steroid Chemistry and Biochemistry
- Synthesis and pharmacology of benzodiazepine derivatives
- Spinal Fractures and Fixation Techniques
- Immune Cell Function and Interaction
- Chemical synthesis and alkaloids
- Neurofibromatosis and Schwannoma Cases
- Facial Nerve Paralysis Treatment and Research
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Brain Metastases and Treatment
- Sesquiterpenes and Asteraceae Studies
- Cell Adhesion Molecules Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Trigeminal Neuralgia and Treatments
- Phytochemistry and Bioactive Compounds
- Protein Interaction Studies and Fluorescence Analysis
- Medicinal plant effects and applications
Meshalkin National Medical Research Center
2023-2024
Ministry of Health of the Russian Federation
2024
Federal Neurosurgical Center Novosibirsk
2015-2020
Siberian Branch of the Russian Academy of Sciences
1998-2011
Russian Academy of Sciences
1984-2008
Novosibirsk Institute of Organic Chemistry
2001-2006
Vellore Institute of Technology University
2006
Institute of Solid State Chemistry
1997-1998
N.D. Zelinsky Institute of Organic Chemistry
1987
Resection of anterior clinoidal meningiomas is a challenging task due to their localization, frequent involvement the major cerebral arteries and cranial nerves, high risk postoperative neurological deficits, low radicalness surgery.To evaluate microsurgical removal deficit in early period patients with meningiomas.A total 35 underwent surgery at Department Neurooncology Novosibirsk Federal Neurosurgical Center from 2013 July 2016. There were 29 (82.9%) females 6 (17.1%) males. The mean...
Besides initiation of tumor-specific T cell immunity, dendritic cells (DCs) are endowed with tumoricidal activity. Previously, we showed that monocyte-derived DCs high-grade glioma patients generated in the presence interferon alpha (IFNα) (IFN-DCs) have impaired cytotoxic activity against tumor necrosis factor (TNFα)-sensitive HEp-2 cells. Herein, demonstrate decreased transmembrane TNFα (tmTNFα) expression, but not soluble (sTNFα) production by patient IFN-DCs, determines defective...
The management of patients with facial nerve palsy is a challenge modern neurosurgery. study purpose was to evaluate the degree function recovery, following trigeminal neurotization. Trigeminal neurotization performed in 23 within 1 10 months after development paralysis. In most cases, cause paralysis surgery for space-occupying lesions cerebellopontine angle (95.6%). Outcomes were evaluated 17 (73.9%) who followed-up more than 6 months. 16 (94.1%) patients, recovered House-Brackmann grade...
The study objective is analysis of surgical treatment results adult patients with tumors the fourth ventricle and determination predictors unsuccessful outcomes. Materials methods. In present we review 33 ventricle, which were operated via telovelar approach in Federal Neurosurgical Center (Novosibirsk). most common symptoms included hydrocephalus (54.5 %), cerebellar dysfunction (33.3 cranial nerve deficits (30.3 %). tumor size was more than 40 mm 22 cases (66.7 brain stem invasion occurred...
Background. Metastases of the female reproductive system cancer to brain are rare and reach about 5 % all cases with metastatic lesions central nervous system. The most common metastases ovarian (0.49–6.1 %), endometrial (0.4–1.2 %) cervical (0.3–0.9 %). predominant localization ways spreading in this category tumors may differ from lung cancer, breast kidney or melanoma. Aim. To analyze malignant dissemination cells primary focus Materials methods. From 2013 2020, a total number 448...
Dendritic cells (DCs) of patients with high-grade brain glioma exhibit impaired expression membrane TNFα associated low DC cytotoxicity against TNF-R1-expressing tumor cell line HEp-2. To assess the significance these findings, we investigated a role TNFα/TNF-R1-signaling pathway in cytotoxic activity allogenic and autologous lines obtained from tissues. DCs were generated by culturing plastic-adherent peripheral blood mononuclear presence GM-CSF IFNα for 4 d followed LPS addition 24 h...
Abstract BACKGROUND Facial nerve paralysis (FP) is a possible complication of cerebellopontine angle tumor surgery. Several donor nerves have been used in the past for facial reanimation. We report results 30 cases masseter-to-facial anastomosis. OBJECTIVE To prospectively evaluate efficacy V to VII anastomosis after FP. METHODS In prospective study, we included consecutive patients with FP (20 women and 10 men) whose mean age was 48.8 yr (32-76 yr). almost all cases, developed surgery (29...
Abstract Title compounds [(VI), (VIII), and (X)] are synthesized starting from harmine (I) via quaternized derivatives (V).
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Dendritic cells (DCs) are the most potent antigen-presenting cells, which play crucial role in initiation and maintenance of immune response. However, DCs high-grade glioma patients characterized by some functional impairment including reduced TNFα-mediated antitumor cytotoxic activity low migratory activity. Tumor-produced soluble molecules can profoundly affect differentiation maturation influence DCs. The aim present study was to determine effect supernatants primary cell lines on...
Glioma is the most common type of primary brain tumor. Despite aggressive therapy, glioma virtually always recurs. Soluble factors produced by cells play an important role in progression tumor growth. Glioma-derived soluble can stimulate cell proliferation autocrine and paracrine manners, affect microenvironment promote angiogenesis metastasis. Besides, glioma-derived cytokines are able to disturb antitumor immune response inhibiting functions effector lymphocytes inducing immunosuppressive...
The authors share a 30-year experience (1983-2013) of successful surgical management female patient with nonspecific aortoarteritis. patient's follow-up allowed us to analyze the development disease and evaluate efficacy reconstructive operation conservative treatment.
Objective: To assess the radicality and neurological deficit in early postoperative period after microsurgery of anterior clinoid process meningiomas.