A5015279280- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Oral and Maxillofacial Pathology
- Neurobiology of Language and Bilingualism
- Bone Tumor Diagnosis and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Lymphoma Diagnosis and Treatment
- Traumatic Brain Injury Research
- Advanced MRI Techniques and Applications
- Soft tissue tumor case studies
- Cerebrovascular and Carotid Artery Diseases
- Medical Imaging and Analysis
- Head and Neck Surgical Oncology
- Neurosurgical Procedures and Complications
- Second Language Acquisition and Learning
- CNS Lymphoma Diagnosis and Treatment
- Hip and Femur Fractures
- Cell Adhesion Molecules Research
- Surgical Sutures and Adhesives
- T-cell and B-cell Immunology
Federal Neurosurgical Center Novosibirsk
2017-2024
Ministry of Health of the Russian Federation
2023-2024
Novosibirsk State Medical University
2023-2024
Krasnoyarsk State Medical University
2022-2023
Tokyo Women's Medical University
2018
Besides initiation of tumor-specific T cell immunity, dendritic cells (DCs) are endowed with tumoricidal activity. Previously, we showed that monocyte-derived DCs high-grade glioma patients generated in the presence interferon alpha (IFNα) (IFN-DCs) have impaired cytotoxic activity against tumor necrosis factor (TNFα)-sensitive HEp-2 cells. Herein, demonstrate decreased transmembrane TNFα (tmTNFα) expression, but not soluble (sTNFα) production by patient IFN-DCs, determines defective...
The study objective is analysis of surgical treatment results adult patients with tumors the fourth ventricle and determination predictors unsuccessful outcomes. Materials methods. In present we review 33 ventricle, which were operated via telovelar approach in Federal Neurosurgical Center (Novosibirsk). most common symptoms included hydrocephalus (54.5 %), cerebellar dysfunction (33.3 cranial nerve deficits (30.3 %). tumor size was more than 40 mm 22 cases (66.7 brain stem invasion occurred...
Background . Meningiomas are the most common extracerebral intracranial neoplasms. Radicality of meningioma resection largely depends on its consistency, size, and closeness to important anatomical structures. Preoperative prognosis density plays an role in selection surgical access operative inventory, general radicality tumor resection, neurological outcome after surgery. Aim To determine predictors consistency using magnetic resonance imaging T1, T2‑mapping technique. Materials methods...
Background. Metastases of the female reproductive system cancer to brain are rare and reach about 5 % all cases with metastatic lesions central nervous system. The most common metastases ovarian (0.49–6.1 %), endometrial (0.4–1.2 %) cervical (0.3–0.9 %). predominant localization ways spreading in this category tumors may differ from lung cancer, breast kidney or melanoma. Aim. To analyze malignant dissemination cells primary focus Materials methods. From 2013 2020, a total number 448...
Introduction. Current approaches used to predict the recurrence of diffuse large B-cell lymphoma (DLBCL) with involvement central nervous system (CNS) need be improved. Data from national studies on incidence and clinical laboratory characteristics primary CNS DLBCL secondary in systemic are fragmentary do not allow us assess overall picture. Aim. An assessment territory Siberian metropolis data patients (PCNSL) involvement, as well validation CNS-International Prognostic Index (CNS-IPI)...
Dendritic cells (DCs) of patients with high-grade brain glioma exhibit impaired expression membrane TNFα associated low DC cytotoxicity against TNF-R1-expressing tumor cell line HEp-2. To assess the significance these findings, we investigated a role TNFα/TNF-R1-signaling pathway in cytotoxic activity allogenic and autologous lines obtained from tissues. DCs were generated by culturing plastic-adherent peripheral blood mononuclear presence GM-CSF IFNα for 4 d followed LPS addition 24 h...
Orbital tumors are a difficult pathology for surgical removal and additionally complicated by the issue of selecting proper approach. Currently, choice approach remains debatable treatment orbital tumors. This paper presents retrospective analysis 26 patients with isolated who were operated on in our neurosurgical center from 2012 till 2020. The series included 15 female 11 male patients, whose age varied 3 to 75 years. most common symptoms lesions exophthalmia (20 pts), retrobulbar pain (15...
Background: Studies on reconstructive neurosurgical interventions are always relevant due to the persistence of cranial defects, mainly caused by traumatic brain injuries (TBI). To provide medical care patients with defects more efficiently, it is necessary assess a large number surgical in studies. Objective: analyze data performed at Novosibirsk hospitals. Methods: We multicenter observational retrospective non-randomized study total cranioplasty from 2016 2022. The involved five...
BACKGROUND: According to 2021 WHS Classification, intracranial hemangiopericytomas or solitary fibrous tumors are rare meningeal neoplasms involving blood vessels and soft tissues. Such commonly classified as malignant due their aggressive growth, metastasizing beyond the cranial cavity, frequent recurrencies. Since these rarely occur in neurosurgical patients, publications Russian do not cover big cohorts of patients whose conditions would be assessed during both early late observation...
Anomalies in the anatomical structure of nasal cavity and paranasal sinuses often serve as a potential cause spontaneous cerebrospinal fluid (CSF) leakage may result development meningoencephalocele. In this report, authors present case surgically treated intrasphenoidal meningoencephalocele attributed to persistence lateral craniopharyngeal canal, which was further complicated by occurrence an intracerebral hematoma.A temporal lobe located recess sphenoid sinus successfully managed using...
Granule-mediated cytotoxicity of effector cells is a universal mechanism tumor growth inhibition and induction cell death. The aim present study was to evaluate expression lytic molecules in DCs generated presence IFNα (IFN-DCs), analyze the role granule-mediated for IFN-DC cytotoxic activity against lines. IFN-DCs were by culturing plastic-adherent peripheral blood mononuclear GM-CSF 4 d followed LPS addition 24 h. lines obtained from malignant tissues patients with glioblastoma multiforme....
Modern neurosurgical practice is impossible without access to various information sources. The use of MRI and MSCT data during surgery an integral part the neurosurgeon's daily practice. Devices capable managing image viewer system direct contact with equipment simplify working in operating room.To test operation a non-contact room evaluate effectiveness.An Opect management developed at Tokyo Women's Medical University was installed one rooms Novosibirsk Federal Center Neurosurgery 2014. In...
Background: Glioblastoma multiforme (GB) is the most common type of primary brain tumors, that virtually always relapses, despite initial treatment with surgical resection, radio- and chemotherapy. Nowadays new promising approaches are developed in treating GB based on dendritic cell (DC) vaccines for enhancement anti-tumor immune response. IFNα-induced monocyte-derived DCs possess properties myeloid DCs, plasmacytoid NK cells. The present study focuses role death-inducing mechanisms DC...
Introduction. Minimally invasive techniques in brain tumor surgery are the priority tasks for preserving function of structures central nervous system adjacent to tumors. The approaches through natural arachnoid spaces avoiding additional trauma intact with dissection falx, can be an alternative conventional direct interhemispheric fissure Results. This paper presents results surgical treatment 18 patients tumors various histological structures, which underwent removal lesions contralateral...