A5001946779- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- HIV Research and Treatment
- Fungal Biology and Applications
- Osteomyelitis and Bone Disorders Research
- Microbial Metabolites in Food Biotechnology
- Hepatitis C virus research
- Liver physiology and pathology
- Orthopedic Infections and Treatments
- Infectious Diseases and Tuberculosis
- Brucella: diagnosis, epidemiology, treatment
- Inflammasome and immune disorders
- Biofuel production and bioconversion
- Bone and Joint Diseases
- Leptospirosis research and findings
- Galectins and Cancer Biology
- Botanical Research and Applications
- Microbial bioremediation and biosurfactants
- SARS-CoV-2 and COVID-19 Research
- Mesenchymal stem cell research
- HIV-related health complications and treatments
- Pancreatic function and diabetes
- Enzyme-mediated dye degradation
- COVID-19 Impact on Reproduction
Consejo Nacional de Investigaciones Científicas y Técnicas
2020-2025
Instituto de Investigaciones Biomédicas en Retrovirus y Sida
2021-2025
University of Buenos Aires
2021-2025
National University of Misiones
2020-2021
Pulmonary and extrapulmonary manifestations have been described after infection with SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19). The virus is known to persist in multiple organs due its tropism for several tissues. However, previous reports were unable provide definitive information about whether viable transmissible. It has hypothesized that persisting reservoirs SARS-CoV-2 tissues could be one potentially overlapping causes long COVID.In present study, we...
Pulmonary and extrapulmonary manifestations have been reported following infection with SARS-CoV-2, the causative agent of COVID-19. The virus persists in multiple organs due to its tropism for various tissues, including skeletal system. This study investigates effects SARS-CoV-2 infection, both ancestral Omicron viral strains, on differentiating mesenchymal stem cells (MSCs), precursor cells, into osteoblasts. Although strains can productively infect osteoblasts, cell remained abortive....
Abstract The Coronavirus Disease 2019 (COVID‐19) pandemic has resulted in the loss of millions lives, although a majority those infected have managed to survive. Consequently, set outcomes, identified as long COVID, is now emerging. While primary target severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) system, impact COVID‐19 extends various body parts, including bone. This study aims investigate effects SARS‐CoV‐2 infection on osteoclastogenesis, utilizing both ancestral and...
Coronavirus disease 2019 (COVID-19) might impact progression in people living with HIV (PLWH), including those on effective combination antiretroviral therapy (cART). These individuals often experience chronic conditions characterized by proviral latency or low-level viral replication CD4+ memory T cells and tissue macrophages. Pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, IFN-γ, can reactivate provirus expression both primary cell lines. cytokines are elevated infected SARS-CoV-2,...
Due to a common mode of transmission through infected human blood, hepatitis C virus (HCV) and immunodeficiency (HIV) co-infection is relatively prevalent. In alignment with this, HCV associated an increased size the HIV reservoir in highly active antiretroviral therapy (HAART)-treated individuals. Hence, it crucial comprehend physiological mechanisms governing latency reactivation reservoirs. Consequently, our study delves into interplay between HCV/HIV liver cells its impact on modulation...
Kingella kingae is an emerging pathogen that causes septic arthritis, osteomyelitis, and bacteremia in children from 6 to 48 months of age. The presence bacteria within or near the bone associated with inflammatory process results osteolysis, but underlying pathogenic mechanisms involved are largely unknown. To determine link between K. loss, we have assessed whether infection per se through genesis a pro-inflammatory microenvironment can promote osteoclastogenesis. For purpose, examined...
Osteoarticular injury is the most common presentation of active brucellosis in humans. Osteoblasts and adipocytes originate from mesenchymal stem cells (MSC). Since those osteoblasts are bone-forming cells, predilection MSC to differentiate into or a potential factor involved bone loss. In addition, can be converted each other according surrounding microenvironment. Here, we study incumbency B. abortus infection crosstalk between during differentiation its precursors. Our results indicate...
Due to a common mode of transmission through infected human blood, hepatitis C virus (HCV) and immunodeficiency (HIV) coinfection is relatively prevalent. In alignment with this, HCV co-infection associated an increased size the HIV reservoir in highly active antiretroviral therapy (HAART)-treated individuals. Hence, it crucial comprehend physiological mechanisms governing latency reactivation reservoirs. Consequently, our study delves into interplay between HCV/HIV liver cells its impact on...
This study aims to explore the influence of coinfection with HCV and HIV on hepatic fibrosis. A coculture system was set up actively replicate both viruses, incorporating CD4 T lymphocytes (Jurkat), stellate cells (LX-2), hepatocytes (Huh7.5). LX-2 cells’ susceptibility infection assessed through measurements receptor expression, exposure cell-free virus, cell-to-cell contact HIV-infected Jurkat cells. The evaluated profibrotic parameters, including programed cell death, ROS imbalance,...
Bone loss is a prevalent characteristic among people with HIV (PWH). We focused on mesenchymal stem cells (MSCs) and osteoblasts, examining their susceptibility to different strains (R5- X4-tropic) the subsequent effects bone tissue homeostasis. Our findings suggest that MSCs osteoblasts are susceptible R5- X4-tropic but do not support productive replication. exposure during osteoblast differentiation process revealed virus could alter mineral organic matrix deposition. However, reduction in...
Sugarcane bagasse is a natural source of phenolic compounds. However, these compounds are bound to lignocellulose components, reducing their ability function as good antioxidants. These linkages hydrolyzed by enzymes like β-glucosidases, increasing free phenolics. Auricularia food-grade genus capable producing β-glucosidases. The aim this work was (I) determine naturally occurring species and (II) obtain through the solid-state bioprocessing sugarcane bagasse. We have successfully isolated...