A5034324583- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Antioxidant Activity and Oxidative Stress
- CAR-T cell therapy research
- Cancer, Stress, Anesthesia, and Immune Response
University of Wisconsin–Madison
2020-2025
Background Allogeneic bone marrow transplant (alloBMT) is curative for hematologic malignancies through the graft-versus-tumor (GVT) effect but has been ineffective solid tumors like osteosarcoma (OS). OS expresses CD155 which interacts strongly with inhibitory receptors TIGIT and CD96 also binds to activating receptor DNAM-1 on natural killer (NK) cells. never targeted after alloBMT. Combining adoptively transferred allogeneic NK (alloNK) cells blockade alloBMT may enhance a GVT against OS....
<h3>Background</h3> Allogeneic bone marrow transplant (alloBMT) is curative for hematologic malignancies through the graft-versus-tumor (GVT) effect but has been ineffective solid tumors like osteosarcoma (OS). OS expresses CD155 which interacts strongly with inhibitory receptors TIGIT and CD96 also binds to activating receptor DNAM-1 on natural killer (NK) cells. never targeted after alloBMT. Combining adoptively transferred allogeneic NK (alloNK) cells blockade alloBMT may enhance a GVT...
Allogeneic bone marrow transplant (alloBMT) is curative for hematologic malignancies through the graft-versus-tumor (GVT) effect but has been ineffective solid tumors like osteosarcoma (OS). OS expresses CD155 which interacts strongly with inhibitory receptors TIGIT and CD96 also binds to activating receptor DNAM-1 on natural killer (NK) cells. never targeted after alloBMT. Combining adoptively transferred allogeneic NK (alloNK) cells blockade alloBMT may enhance a GVT against OS.
<h3>Background</h3> Relapsed pediatric sarcomas have a poor prognosis with no available curative options. Alpha-Tocopheryloxyacetic acid (a-TEA) is redox-silent analog of alpha-tocopherol that induces apoptotic and immunogenic cell death tumor cells at doses are not harmful to healthy normal cells. In first-in-human clinical trial, a-TEA was well tolerated in adults advanced solid tumors (NCT02192346), but has yet been studied sarcoma. We used murine model rhabdomyosarcoma (M3-9-M RMS)...
Abstract Relapsed sarcomas remain essentially incurable for most children with cancer. Alpha-Tocopheryloxyacetic acid (αTEA) is a scalable semi-synthetic derivative of alpha-tocopherol that has shown promising activity preclinically and clinically in adult cancer, but not yet been studied pediatric sarcoma. We hypothesized αTEA would mediate anti-tumor effects rhabdomyosarcoma (RMS) by modulating the immunosuppressive milieu. Treatment murine M3-9-M RMS vitro (2.5–100uM) resulted increased...