A5059572688- DNA Repair Mechanisms
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Speech and Audio Processing
- Speech Recognition and Synthesis
- Metabolism, Diabetes, and Cancer
- Carcinogens and Genotoxicity Assessment
- Cancer-related Molecular Pathways
- Polymer Surface Interaction Studies
- Blind Source Separation Techniques
- Biochemical effects in animals
- Plant tissue culture and regeneration
- Healthcare and Venom Research
- Fungal and yeast genetics research
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Viral Infectious Diseases and Gene Expression in Insects
- Stress Responses and Cortisol
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer therapeutics and mechanisms
- Obesity, Physical Activity, Diet
Fudan University
2024-2025
University of Pennsylvania
2004-2024
Sichuan University
2017-2024
West China Hospital of Sichuan University
2017-2024
State Key Laboratory of Oral Diseases
2024
University of Chinese Academy of Sciences
2024
Institute of Process Engineering
2024
Chinese Academy of Sciences
2024
The People's Hospital Tongling
2020-2021
Anhui University
2020
Genetic disorders affecting cellular responses to DNA damage are characterized by high rates of translocations involving antigen receptor loci and increased susceptibility lymphoid malignancies. We report that the Nijmegen breakage syndrome protein (NBS1) histone gamma-H2AX, which associate with irradiation-induced double-strand breaks (DSBs), also found at sites VDJ (variable, diversity, joining) recombination-induced DSBs. In developing thymocytes, NBS1 gamma-H2AX form nuclear foci...
Abstract Traditional adhesion coupling agents based on small molecules often face challenges such as uneven interface distribution, sensitivity to humidity, and lack of energy dissipation in bulk adhesives, which limit both performance long‐term reliability. In this work, amphiphilic block copolymer brushes are presented a new type agent overcome these issues. The hydrophilic forms stable, multi‐site interactions with the substrate, while hydrophobic penetrates entangles adhesive matrix,...
Abstract A new concept is proposed to synthesize mesoporous magnetic nanocomposite particles of great scientific and technological importance. Mesoporous silica coatings were created on micrometer‐sized magnetite (Fe 3 O 4 ) using cetyltrimethylammonium chloride micelles as molecular templates. The characterization by transmission electron microscopy (TEM), nitrogen adsorption–desorption, diffuse‐reflectance Fourier‐transform infrared spectroscopy, zeta‐potential measurements confirmed the...
Restriction enzyme-mediated events (REM events; integration of transforming DNA catalyzed by in vivo action a restriction enzyme) and illegitimate recombination (IR that shares no homology with the host genomic sequences) have been previously characterized Saccharomyces cerevisiae. This study determines effect mutations genes are involved homologous and/or repair double-stranded breaks on these events. Surprisingly, REM completely independent double-strand-break functions encoded RAD51,...
We report a "grafting to" method for stably grafting high-molecular-weight polymer brushes on both active and inert surfaces using tadpole-like single-chain particles (TSCPs) with an interactive "head" as units. The TSCPs can be efficiently synthesized through intrachain cross-linking one block of diblock copolymer; the is cross-linked particle, "tail" linear chain that has contour length up to micrometers. When grafted surface, "head", integrating numerous interacting groups, synergize...
There is plenty of evidence showing that autophagy plays an important role in the biological process cancer. The purpose this study was to establish a novel autophagy-related prognostic marker for lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC).The mRNA microarray clinical data Cancer Genome Atlas (TCGA) were analyzed by using univariate Cox proportional regression model select candidate genes. Bioinformatics analysis gene function Gene Ontology (GO) Kyoto Encyclopedia Genes...
N6-methyladenosine (m6A) methylation plays a critical role in diverse biological processes. However, knowledge regarding the constitution of m6A on tumor microenvironment (TME) and tumor-infiltrating lymphocytes (TILs) across cancer types is still lacking. We performed comprehensive immuno-genomic analyses to reveal molecular characterization regulators immune-related genes (IRGs) TME TIL heterogeneity.We comprehensively analyzed properties genomic profiles from The Cancer Genome Atlas...
Chromosome aberrations may cause cancer and many heritable diseases. Topoisomerase I has been suspected of causing chromosome by mediating illegitimate recombination. The effects deletion overexpression the topoisomerase gene on recombination in yeast Saccharomyces cerevisiae have studied. Yeast transformations were carried out with DNA fragments that did not any homology to genomic DNA. frequency integration was 6- 12-fold increased a strain overexpressing compared isogenic control strains....
Lung cancer is the most commonly diagnosed and leading cause of cancer-related death. Among these, lung adenocarcinoma (LUAD) accounts for cases. Due to improvement precision medicine based on molecular characterization, treatment LUAD underwent significant changes. With these changes, prognosis becomes diverse. N 6 -methyladenosine (m A) predominant modification in mRNAs, which has been a research hotspot field oncology. Nevertheless, little studied reveal correlations between m A-related...
NLRP3 inflammasome is critical in the development and progression of many metabolic diseases driven by chronic inflammation, but its effect on pathology postmenopausal osteoporosis (PMOP) remains poorly understood.
Prohibitin, which can inhibit oxidative stress and mitochondrial dysfunction, has been shown to have significant anti-inflammatory activities. Here, we investigate the effects of altering prohibitin levels in affected tissues interleukin-10 knockout (IL-10KO) mouse model with intestinal fibrosis. The aim this study is IL-10 on role fibrosis murine colitis. After mice were treated IL-10, expression localization evaluated IL-10KO wild-type (WT, 129/SvEv) mice. colon tissue was then...
Surgical guides are commonly used to assist with dental implant placement. This study investigated the effects of five sterilization and disinfection methods on accuracy guides.
Praja2 (Pja2), a member of the growing family mammalian RING E3 ubiquitin ligases, is reportedly involved in not only several types cancer but also neurological diseases and disorders, genetic mechanism underlying regulation Pja2 nervous system remains unclear. To study cellular molecular functions mouse hippocampal neuronal cells (MHNCs), we used gain- loss-of-function manipulations HT-22 tested their regulatory effects on three Alzheimer's disease (AD) genes cell proliferation. The results...
Objective: To explore the effect of moxibustion at Shenque(CV8) on myocardial structure and function in rats with exercise-induced fatigue. Methods: A 12-week treadmill training program was used to establish a rat model Fifty-six male SD removed six that did not reach molding condition, Remaining were randomly divided into following five groups: normal group (n=10) under go exercise routine treated, control routine, but received mild dose “Shenque” (CV 8) for 15 min, an untreated no...
Abstract In this experiment, Sprague–Dawley rats with elastase‐induced emphysema were imaged using hyperpolarized 3 He MRI. Regional fractional ventilation r , the fraction of gas replaced a single tidal breath, was calculated from series images in wash‐in study gas. We compared regional these emphysematous to ventilations we previous baseline healthy rats. found that there differences maps and its associated frequency distribution between rat lungs. Fractional tended be much lower than...
Obstructive sleep apnea (OSA) is a worldwide health issue that affects more than 400 million people. Given the limitations inherent in current conventional diagnosis of OSA based on symptoms report, novel diagnostic approaches are required to complement existing techniques. Recent advances gene sequencing technology have made it possible identify greater number genes linked OSA. We identified key and CPAP treatment by screening differentially expressed (DEGs) using Gene Expression Omnibus...
Electrospray ionization (ESI) coupled with tandem mass spectrometry has been used in conjunction microwave-mediated saponification, periodate oxidation, and clostridial sialidase hydrolysis to enable detailed structural characterization of gangliosides their derivatives present mullet milt. The extracted from milt were determined be GM3, GM3 lactone, methyl ester, 9-O-acetyl GM3. For the major ganglioside all derivatives, ceramide composition was revealed C18:1/C16:0. a C18:0/C16:0 also...