To investigate in vitro antimalarial activity of chalcone derivative compounds against Plasmodium falciparum 3D7 (Pf3D7) strain and silico activity. Synthesis the derivatives was conducted via Claisen-Schmidt method using NaOH 60% base as catalyst. An assay carried out according to Rieckmann chloroquine-sensitive Pf3D7 strain. Molecular docking studies prepared were performed Discovery Studio 3.1 (Accelrys, Inc., San Diego, USA) software dihydrofolate reductases–thymidylate synthase...

Performance tests on caffeine’s corrosion inhibition properties and their derivatives against copper have been previously reported experimentally using gravimetric electrochemical analyses. The test was able to measure the efficiency of accurately. However, caffeine its derivatives’ structure patterns coating mechanisms when interacting with metals during not explained in detail by experimental studies. In present study, theoretical density functional study (DFT), ab initio MP2, Monte Carlo...

Indonesia is rich with essential oils such as anise and clove leave oils. In respect to explore the potential utilization of these resources, it has been conducted transformation p-hydroxybenzaldehyde vanillin (4-hydroxy-3-methoxy benzaldehyde) respectively derived from oil leaves a series C-arylcalix[4]resorcinarenes C-arylcalix[4]pyrogallolarene macrocycles. Treatment aldehydes resorcinol in presence HCl absolute ethanol at reflux for 8 h afforded C-4-hydroxyphenylcalix[4]resorcinarene...

Radikal bebas merupakan suatu atom atau molekul yang memiliki elektron tidak berpasangan pada orbital terluarnya sehingga membuat ini sangat reaktif dan stabil. apabila terpapar terus menerus didalam tubuh dipercaya dapat menyebabkan beberapa penyakit diantaranya aterosklorosis, iskemik, kanker penuaan dini diperlukan adanya senyawa antioksidan untuk menghambat pembentukan radikal bebas. Kastuba (Euphorbia Pulcherrima Willd.) salah satu tanaman berpotensi sebagai alami. Tujuan penelitian...

Quantitative structure–activity relationship (QSAR) and molecular docking approach were carried out to design novel anti-tuberculosis agents based on xanthone derivatives. QSAR designed new compounds calculated by Austin Model 1 (AM1) methods analysis of multi-linear regression (MLR). The result showed that the best model as follows: Log IC50 = 3.113 + 11.627 qC1 15.955 qC4 11.702 qC9, this has appropriate some statistical parameters (PRESS 2.11, r2 0.730, SEE 0. 3545, R 0.6827, FCal/FTab...

Oriental Journal of Chemistry is a peer reviewed quarterly research journal pure and applied chemistry. It publishes standard papers in almost all thrust areas current chemistry academic commercial importance. provides platform for rapid publication quality papers, reviews letters. abstracted indexed reputed National International agencies.

Objective: To synthesize chalcone derivatives and investigate their antimalarial activity toward chloroquine-sensitive Plasmodium falciparum 3D7 (Pf3D7) strain; to develop quantitative structureactivity relationships (QSAR) model estimate IC 50 values for biological of compared experimental measurement; determine the binding interactions most active compounds with targeting P. dihydrofolate reductase-thymidylate synthase using molecular docking simulation.Methods: Seven have been synthesized...

The increasing rate of cancer chemoresistance and adverse side effects therapy have led to the wide use various chemotherapeutic combinations in management, including lymphoid malignancy.We investigated a combination 1,3,6-trihydroxy-4,5,7-trichloroxanthone (TTX) doxorubicin on Raji lymphoma cell line.Raji cells were treated with different concentrations TTX, doxorubicin, or thereof. Cancer growth inhibition was evaluated using 3-(4,5-dimethyltiazol-2-yl)-2,5- diphenyltetrazolium bromide/MTT...

Assessment of treatment pattern uncomplicated malaria in peadiatric patients attending a teaching hospital northwest NigeriaIshola I.O.,Oreagba I.A.,Olayemi S.O, Gbadamosi R

IntisariLatar Belakang: Dioscorea alata L. sebagai salah satu sumber pati perlu dipelajari untuk pengembangan potensial tablet disintegran.Tujuan: Tujuan penelitian ini adalah mengetahui karakteristik dan potensi bahan disintegran tablet.Metode: Analisis meliputi proksimat, kandungan amilosa, morfologi granular, kristalinitas, kekuatan pengembangan, pengikatan kapasitas air. Studi dilakukan dengan merumuskan piroksikam menggunakan L.. Evaluasi sifat-sifat uji disintegrasi, kerapuhan,...

(PDF) Graphical Abstract: In this study, the chloro-substituted hydroxyxanthones were prepared by cyclodehydration of acid derivatives and substituted phenol in presence Eaton reagent, followed halogenations step to electrophilic substitution chlorine a moderate yield. The vitro anticancer activity study on various cell lines revealed that chloro functional group increases hydroxyxanthone derivatives. molecular docking showed there was binding interaction between chloro-hydroxyxanthone amino...

Some new hydroxyxanthone compounds were prepared through one pot cyclodehydration reaction of hydroxybenzoic acid derivatives (salicylic or resorcylic acid) with phloroglucinol pyrogallol in the presence Eaton's reagent (P 2 O 5 /MeSO 3 H).The synthesized screened for their antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods to determine inhibitory concentration (IC 50 ).Cytotoxicity was also evaluated MMT assay on Vero cell line.It observed that position and number...

Aminoalkylated chalcone compounds (4a-4c) have been designed using Quantitative Structure-Activity Relationship (QSAR) analysis, synthesized and evaluated for their in vitro antimalarial activity.The best QSAR model obtained was log IC 50 = 705.132(qC7) -65.573 (qC3) -24.845 (qC4) -4.634 (qC13) -220.479 statistical analysis showed R 2 of 0.937, suggesting that the able to predict actual activity by 93.7% accuracy.The addition secondary amines successfully carried out Mannich reaction, which...

Many studies have been conducted and developed on cellulose-based battery separator materials, including bacterial cellulose, which has characteristics like plant cellulose. This research aims to synthesize BC/Al2O3 composite analyze its potential as a separator. The synthesis of the with ex-situ method is immerse BC from tofu liquid waste (fermentation time variation 6, 7, 8 days) into Al2O3 suspension. characterization results showed that immersion in can increase porosity, electrolyte...

The objective of this research was to synthesize new compounds with potential biological activity from readily accessed natural products. Eugenol has been reported posses antioxidant and anticancer properties prepared by extracting clove buds dichloromethane followed isolation using column chromatography afford pure eugenol (73%). In an attempt enhance intrinsic compound, some derivatives were possible synthesize. main aim preliminary transform become sulfonic derivative. transformed its...

Sponges are marine biota that makes up coral reefs live on the bottom of waters and have an important role in ecosystems. bioactive components not been widely used by community. This study aimed to analyze content secondary metabolites antibacterial activity sponge Stylotella sp. test against Gram-negative (-) Escherichia coli Gram-positive (+) Staphylococcus aureus was carried out using good diffusion method. The results testing with various concentrations 50, 100, 150 ppm isolates showed...

To determine the free-radical scavenging activity and total phenolic content of ethanol extract Poinsettia leaves (Euphorbia pulcherrima Willd.) from Lombok Island, we used 1,1-diphenyl-2-picrylhydrazyl method expressed as gallic acid equivalent (GAE) per gram extract. The results show strong antioxidant (79.77 ppm) red moderate green (118.350 ppm). extracts possessed an average 63.276 ± 0.228 22.715 0.090 mg GAE/g contents, respectively. In addition, exhibited inhibitory activities, These...

Antibacterial assay of series hydroxyxanthone that was a synthesis via cyclization phenol derivatives and acid with Eaton Reagent has been investigated through Escherichia coli, Bacillus cereus, Staphylococcus aureus Salmonella typhimurium by diffusion well method. The possess antibacterial activity against Methicillin-resistant (MRSA) reported molecular docking. result reveals the 1,3,6-tryhydroxyxanthone were effective in inhibiting growth inhibition zone 30, 35, than 34 mm respectively...

Eugenol is a compound with variety of reactive functional groups such as allyl, hydroxy and methoxy. The presence the brings eugenol possible to undertake transformation into various derivative compounds diverse activities. One simple transformations methylation or alkylation. Commonly, methyl halides dimethyl sulphate are used agent. However, those kinds agents toxic carcinogenic. In this research carbonate, an alternative agent used, because its low toxicity, green, economic. synthesis has...

Covid-19 has caused more than 14 million confirmed cases and 6 hundred deaths as of 21 July 2020 globally. However, there is no approved drug to treat the disease. Xanthone a potential therapeutic option for virus that have been tested using molecular docking. There were 12 xanthone compounds its derivatives which docked against two protein crystals, 2GX4.pdb 6FV1.pdb, obtained hydroxyxanthone with sulfonate chloro substitution. These are potentially developed into one agents treatment...

Fatty hydroxamic acids (FHA) have been successfully synthesized from Terminalia catappa L. (local name: ketapang) kernel oil by a one-step lipase catalyzed reaction. The use of immobilized as catalyst to synthesize FHA has several advantages such simple purification product and environmentally friendly. In addition, it also allows the reaction be carried out under mild conditions, which reduces reaction’s side products. optimal condition obtains were 40°C temperature for 25 h with ratio...

This study aimed to propose new indole derivatives as anticancer through Quantitative Structure-Activity Relationship (QSAR) and molecular docking method. The best predicted activity of was recommended based on the QSAR equation. A data set consist 18 from literature with against A498 cell line used generate a model divided randomly into training (14) test (4) compounds. structure compound optimized first using AM1 semi-empirical methods, descriptors involved were analyzed Multiple Linear...

Desa Jurit Baru merupakan salah satu desa di kabupaten Lombok Timur yang memiliki hasil perkebunan berupa nira aren. Selama ini aren didapatkan belum dimanfaatkan secara optimal. Salah olahan dapat dijadikan bahan makanan adalah produk nata. Oleh sebab itu dilakukan suatu kegiatan sosialisasi melalui program pengabdian kepada masyarakat bertujuan meningkatan pengetahuan, sikap, dan keterampilan tentang pemanfaatan sebagai baku pembuatan nata serta merangsang minat kewirausahaan peserta....

The synthesis of environmentally friendly-based chemicals such as solvent-free continues to be developed. A critical precursor in chemical is benzoic acid. This research developed a method by utilizing TiO2 nanomaterials with different morphologies photocatalysts, namely nanoparticles (NPs) and nanowires (NWs). Titanium (IV) oxide morphology was synthesized hydrothermal under alkaline conditions. SEM, XRD, FT-IR images confirmed the NPs NWs. Photocatalytic performance converting benzaldehyde...