Sex steroids are required for a normal pubertal growth spurt and fusion of the human epiphyseal plate. However, localization sex steroid receptors in plate remains controversial. We have investigated expression estrogen receptor (ER) alpha, ERbeta androgen (AR) biopsies proximal tibial plates obtained during surgery 16 boys eight girls. All stages were represented (Tanner 1-5). ERalpha, AR visualized with immunohistochemistry number receptor-positive cells was counted using an image analysis...

Update This article was updated on December 31, 2020, because of a previous error. On page 1460, in the “Results” section Abstract, sentence that had read “The surgical treatment group significantly better pain, activity, and self-image domain scores at 5 years postoperatively compared with untreated AIS (all p ≤ 0.014), similar self-image, activity healthy control group; function were lower (p < 0.001).” now reads however, among patients An erratum has been published: J Bone Joint Surg...

43 children between the ages of 7 and 15 years with clinical symptoms acute appendicitis were randomised to an open appendectomy (OA) or a laparoscopic (LA). There cases 5 perforated appendices in OA group 17 appendicitis, 3 other diagnoses LA group. The operative time was little shorter no differences hospital stay postoperative course patients. In group, there two minor complications, complications seen. When comparing surgical methods consistent patients non-perforated statistical seen...

We compared the clinical, radiological and quality-of-life outcomes between hybrid total pedicle screw instrumentation in patients undergoing surgery for neuromuscular scoliosis. A matched comparison using prospectively collected data was undertaken. of 66 underwent posterior or anteroposterior correction fusion with (n = 33, mean age at 15.8 years (9.10 to 19.6)) 14.7 (7.0 20.7)) a minimum follow-up two years. The major curve pre-operatively 87° (sd 29, 25° 141°) 81° 18, 47° 116°) groups,...

Within a 3-year period, from 1980 to 1982, 1124 sports injuries of children aged 6-15 years were treated in the Turku University Central Hospital casualty department. Two-thirds (69%) sustained by boys. Sports represented 21% diagnoses related accidents this age group. Half occurred during 4 winter months. Boys injured most commonly ice hockey (36%) and football (20%) girls skating (18%) riding (18%). One quarter (26%) located head neck, 36% upper extremities, 33% lower limbs, 4% trunk. The...

Background and Aims: Appendectomy wounds are still commonly closed with non-absorbable sutures. Stitch removal has financial costs causes anxiety in children. Our aim was to compare interrupted (NA) continuous intradermal absorbable (A) sutures appendectomy evaluate whether suturing increases the risk of complications. Material Methods: 198 children (age 4–18 years) including perforated cases were prospectively randomized into two groups (NA A skin closure). The inflammatory markers...

Background: Unstable antebrachium diaphyseal fractures in children are nowadays increasingly treated operatively by elastic intramedullary nailing. Aim: Aim of the study was to critically assess both radiological and functional outcome titanium nail (TEN) a pediatric cohort. Material Methods: This retrospective investigated 75 consecutive children, who were for shaft at Tampere University Hospital during time period from January 2001 December 205. All classified according OTA. Thirty-five...

Aneurysmal bone cysts represent about 1% of primary tumors. The standard treatment is curettage, followed by local adjuvant treatments and grafting. problem the high recurrence rate. purpose this study was to evaluate retrospectively use bioactive glass as a filling material in aneurysmatic children.A total 18 consecutive children (mean 11.3 years at surgery; 10 males; 11 lower, 6 upper limb, 1 pelvis; 15 with surgery) histologically proven aneurysmal operated curettage between 2008 2013...

Aims In a multicentre, randomised study of adolescents undergoing posterior spinal fusion for idiopathic scoliosis, we investigated the effect adding gelatine matrix with human thrombin to standard surgical methods controlling blood loss. Patients and Methods in intervention group (n = 30) were receive minimum two maximum four units addition conventional achieving haemostasis. Only used control 30). We measured intra-operative total loss (intra-operative plus post-operative drain output)....

We report the results of vertebral column resection (VCR) for paediatric patients with spinal deformity. A total 49 VCRs in from four university hospitals between 2005 and 2009 a minimum two-year follow-up were retrospectively identified. After excluding single hemivertebral resections (n = 25) performed myelomeningocele 6), as well spondylectomies tumour 4), there 14 who had undergone full VCR at mean age 12.3 years (6.5 to 17.9). The aetiology was congenital scoliosis five, neuromuscular...

Studies of pediatric and adolescent fractures in general report a significant increase the incidence upper-extremity as well their surgical treatment. The aim this study was to determine trends treatment distal humeral hospitalized 0- 18-year-old patients Finland.The included entire (<19 years) population Finland during 24-year period from 1 January 1987 31 December 2010. Data on were obtained nationwide National Hospital Discharge Registry where information is collected all hospital...

Despite several potential complications of elastic intramedullary nailing, it is currently the treatment choice for femoral diaphyseal fractures in school-aged children. This study aimed to critically evaluate titanium nailing pediatric shaft fractures.This evaluated patients with a fracture treated (TEN) Tampere University Hospital Finland. The group included 32 children mean age 9 years during 5-year period, from 1 January 2003 31 December 2007. Data were collected medical records and...

Background: Many studies have been carried out on the effects of anaesthetic drugs and methods immune response, but pain its relief also affect response. We measured systemic responses in blood circulation local surgical wound when non‐steroidal anti‐inflammatory analgesics (NSAIDs), opioids or epidural blockade was used peri‐operative treatment pain. Methods: Responses were 51 children, aged from 2 to 12 years undergoing major surgery under balanced anaesthesia. Bolus doses diclofenac...

<b>Background</b> There are only few studies of Lisfranc injuries in children and adolescents. The aim this study was to evaluate the mid-term results operatively treated injuries. <b>Methods</b> Seven adolescents were Tampere University Hospital between 2004 2009. In four seven feet, trauma comprised all metatarsal bones. All patients with open reduction internal fixation. A questionnaire concerning function pain foot sent patients. <b>Results</b> but one case, anatomical achieved held...

Background: Pregabalin as part of a multimodal pain-management regimen has been shown to reduce opioid consumption after spinal surgery in adults but it is unclear whether this also true adolescents. found have neuroprotective effects and therefore could positive impact on pain deformity surgery. We conducted randomized, double-blinded, placebo-controlled clinical trial adolescent patients undergoing fusion evaluate the short-term pregabalin postoperative consumption. Methods: Adolescents...

Background and Aims: Surgical site infections are relatively common after spinal deformity surgery. Early detection of deep wound is important, since it may allow retention instrumentation. However, serum C-reactive protein erythrocyte sedimentation rate remain elevated for almost 6 weeks, making differential diagnosis systemic inflammatory response acute bacterial infection difficult. Plasma procalcitonin has been suggested to be a useful indicator infection. there no studies evaluating...

Interleukin‐6 and matrix metalloproteinase–9 concentrations in the wound fluid their associations to cellular changes were determined early healing. Wound healing of 75 children who underwent elective operations was studied with Cellstick® device, which inserted into at end operation removed 3 or 24 hours post‐wounding. Differential counts cells interleukin‐6 metalloproteinase‐9 analyzed. increased parallel ( r = 0.81). The proportion neutrophils p &lt; 0.0001) lymphocytes decreased between...

A prospective study on clinical, radiographic, and health-related quality of life (HRQoL) outcomes in children with acute spondylolysis treated a rigid thoracolumbar orthosis or an elastic lumbar support.To compare pediatric spondylosysis hard brace support.The benefits the use treatment are not clear.Fifty-seven consecutive (mean age: 14.1 yr, range: 9-17 yr) were prospectively enrolled. Patients (Boston brace) low-profile, support. First 14 patients randomized remaining 43 chose type...

Study Design. A prospective, comparative study on clinical, radiographic, and health-related quality of life (HRQoL) outcomes in adolescents with acute spondylolysis treated a rigid thoracolumbar orthosis (Boston brace) or placebo (elastic lumbar support) 2-year follow-up time. Objective. To compare adolescent Summary Background Data. The benefits the use for treatment achieving bony union remains unclear. Methods. Sixty consecutive patients were prospectively enrolled. Three excluded from...

The migration of inflammatory cells into a wound and their subsequent changes during healing are essential for the complex processes tissue repair to occur. aim this work was investigate number leukocytes early at different time periods in children. Wound 184 children aged 0–15 years, operated on benign disease lower abdominal region, were harvested with Cellstick® device. device removed from 3, 6, or 24 hours after surgery differential cell counts performed. cellular patterns significantly...

Studies among children experiencing fractures report an increasing trend toward operative management. In the present study, we examined whether same has occurred for humeral shaft in accordance with interest intramedullary nailing and other treatments. The number, incidence treatment of all hospitalised 0- to 16-year-old patients Finland was assessed over a recent 24-year period.The study included entire adolescent (0-16 years) population during period from January 1, 1987, December 31,...

Summary We studied perioperative changes in the immune response and compared peripheral blood with those wound 20 boys (0.5–3 years) during elective inguinal surgery under balanced anaesthesia. Blood samples were drawn before premedication, immediately, 4 or 24 h after Cells from harvested Cellstick device, removed ( n =10) found decreased lymphocyte counts blood, increased percentages of activated T lymphocytes B lymphocytes, total helper cells cytotoxic cells. The lower than blood....

To compare outcomes between posterior spinal fusion of juvenile idiopathic scoliosis and adolescent patients with a minimum 2-year follow-up. The were fused to the stable vertebra touched vertebra. We hypothesized that extending in would provide similar compared adolescents.A prospective comparative study 21 consecutive children (Risser 0) 84 ⩾2) (1:4 ratio) undergoing bilateral segmental pedicle screw instrumentation direct vertebral derotation follow-up.Juvenile had significantly larger...