A5018690018- Amyotrophic Lateral Sclerosis Research
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Extracellular vesicles in disease
- RNA regulation and disease
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Alcoholism and Thiamine Deficiency
- Enterobacteriaceae and Cronobacter Research
- Probiotics and Fermented Foods
- Oral microbiology and periodontitis research
University of Milan
2014-2024
Ospedale dei Bambini Vittore Buzzi
2023-2024
University of L'Aquila
2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2014
Fibroblasts in the tumor microenvironment have been proven to actively participate progression; they can be "educated" by cancer cells acquiring an activated state and, as such, are identified cancer-associated fibroblasts (CAFs); CAFs, turn, remodel stroma more advantageous for progression modulating several processes, including angiogenesis, immunosuppression, and drug access, presumably driving chemoresistance. That is why believed hamper response clinical therapeutic options. The...
Alpha-synuclein, encoded by the SNCA gene, is a pivotal protein implicated in pathogenesis of synucleinopathies, including Parkinson's disease. Current approaches for modulating alpha-synuclein levels involve antisense nucleotides, siRNAs, and small molecules targeting SNCA's 5′-UTR mRNA. Here, we propose groundbreaking strategy G-quadruplex structures to effectively modulate gene expression lowering amount. Novel sequences, identified on gene's transcription starting site mRNAs, were...
Deregulation of transcription in the pathogenesis sporadic Amyotrophic Lateral Sclerosis (sALS) is taking central stage with RNA-sequencing analyses from sALS patients tissues highlighting numerous deregulated long non-coding RNAs (lncRNAs). The oncogenic lncRNA ZEB1-AS1 strongly downregulated peripheral blood mononuclear cells patients. In addition, cancer-derived cell lines, belongs to a negative feedback loop regulation hsa-miR-200c, acting as molecular sponge for this miRNA. role has not...
The role of extracellular vesicles (EVs) as mediators cell-to-cell communication in cancer progression is widely recognized. In vitro studies are routinely performed on 2D culture models, but recent suggest that 3D cultures could represent a more valid model. Human ovarian cells CABA I were cultured by the hanging drop method to form tumor spheroids, moved low adhesion supports observe their morphology Scanning Electron Microscopy (SEM) and isolate EVs. EVs release was verified SEM identity...
ABSTRACT Alpha-synuclein, encoded by the SNCA gene, is a pivotal protein implicated in pathogenesis of synucleinopathies, including Parkinson’s disease. Current approaches for modulating alpha-synuclein levels involve antisense nucleotides, siRNAs, and small molecules targeting SNCA’s 5’-UTR mRNA. Here, we propose groundbreaking strategy G-quadruplex structures to effectively modulate gene expression lowering amount. Novel sequences, identified on gene’s transcription starting site mRNAs,...
Abstract Leukodystrophies are a class of rare heterogeneous disorders which affect the white matter brain, ultimately leading to disruption in brain development and damaging effect on cognitive, motor social‐communicative development. These present great clinical heterogeneity, along with phenotypic overlap this could be partially due contributions from environmental stimuli. It is context that there need investigate what other factors may contribute both disease insurgence phenotypical...