Multitarget-directed drugs (hybrid drugs) constitute an efficient avenue for the treatment of multifactorial diseases. In this work, novel naphthalene hybrids with different heterocyclic scaffolds such as nicotinonitrile, pyran, pyranopyrazole, pyrazole, pyrazolopyridine, and azepine were efficiently synthesized via tandem reactions 3-formyl-4H-benzo[h]chromen-4-one 1 nucleophilic reagents. Analysis these using PASS online software indicated predicted biological activities anticancer,...

The main target of this paper was the synthesis novel azo disperse dyes with better dyeing properties, together a systematic investigation to determine their dominant tautomer(s) from 12 possible tautomeric structures. In regard, azopyrazolin-5-one were synthesised via reaction hydrazine hydrate 2,3,4-chromantrione-3-arylhydrazones. acid dissociation constants both in ground and excited state for series prepared determined correlated by Hammett equation. results correlation, spectral data,...

As a part of our ongoing interest in disperse dyes and task specific azo with better dyeing properties, we synthesized series 3<i>-</i>aryl(hetaryl)hydrazono-2,4-chromandiones 4a-k<b> </b><i>via</i> Coupling 4-hydroxycoumarin diazotized aniline derivatives. Structures the compounds have been investigated by means UV, IR, <SUP>1</SUP>H-NMR mass spectroscopy order to elucidate their tautomeric isomeric structures. The results such spectral data indicated that 4a-k exist predominantly hydrazo...

Condensation of 1,3-thiazolidinone derivatives 1a-c with different aromatic aldehydes and/or aryldiazonium chlorides gave the corresponding arylidenes 2-10 and arylazo-1,3-thiazolidinones 12-20. Bromination 12 resulted in formation dibromo derivative 21. Treatment HCHO-piperidine Mannich adduct 24. Compound 1a was hydroxymethylated, oxidized formylated to yield products 25-28. The structures new were confirmed by spectral analytical methods.

Abstract Condensation of 3‐formyl chromone 1 with hydroxylamine hydrochloride afforded the corresponding oxime 2 that was converted to nitrile 3 . Refluxing and/or aceturic or hippuric acid gave 16 and 17 Treatment semicarbazide thiosemicarbazide carbazones 5–6 underwent cyclization ethyl bromoacetate chloroacetone yielding 7–8 Also reacted acyclic active methylene reagents, e.g. malononitrile, cyanoacetate, acetoacetate form compounds 11, 12 , 13 Reaction bifunctional benzil,...

Novel azopyrazolin-5-one dyes 4a-f were synthesized by the regioselective reaction of phenylhydrazine with 2,3,4-chromantrione-3-arylhydrazones 2a-f. The acid dissociation constants <TEX>$pK_a$</TEX> for series prepared determined and correlated Hammett equation. results such correlation together spectral data indicated that studied compounds exist predominantly in hydrazone keto structure, (D) as Z-configuration. applied to polyester fabrics, affording orange-yellow shades assessments their...

In an attempt to find a new class of bisazo disperse dyes with better dyeing properties, series novel dyestuffs based on 4-arylhydrazono-3-(2'-hydroxyphenyl)-1-phenyl-2-pyrazolin-5-ones <TEX>$\mathbf{3a-f}$</TEX> were prepared by diazocoupling p-nitrophenyl diazonium chloride <TEX>$\mathbf{2a-f}$</TEX>. Compounds subsequently reacted acetic anhydride in the presence p-toluenesulfonic acid afford corresponding O-acetyl derivatives <TEX>$\mathbf{4a-f}$</TEX>. The latter products as well...

The versatile precursor 2-acetyl-4-allyl-1-hydroxy naphthalene was synthesized efficiently via Claisen rearrangement 2-acetyl-1-allyloxynaphthalene. Claisen-Schmidt condensation of latter afforded the corresponding chalcones which were exploited to synthesize a series potential heterocycles such as pyrazoline, isoxazoline, benzocoumarin and benzoflavone. products showed potent antioxidant antimicrobial activities. Chalcone

Reaction of substituted pyrazolin-5-one and 3-phenyl-5-isoxazolone 1a-c with phenyl isothiocyanate in basic DMF gave the non-isolable sodium salt adduct 2a-c which was treated HCl to give corresponding thiocarbamoyl derivatives 3a-c . The latter compounds underwent heterocyclization upon treatment chloroacetyl chloride ethyl bromoacetate thiazolidinone 6 7 Compound 3a,b oxidized yield benzothiazoly pyrazolinone 8a,b Also, nucleophilic substitution 2 3 different reagents afforded products...

A convenient synthetic protocol for the synthesis of novel chromenopyrimidine derivatives based on angular scaffold has been developed from readily available enaminonitrile precursor 1 . The skeleton chromenopyrimidines decorated with different moieties in order to approach compounds improved antioxidant and antimicrobial activities. Compound was reacted Ac 2 O yield benzochromenopyrimidine 6 that gave chloropyrimidine 7 via chlorination reaction. reaction amines afforded a series...

Abstract Review: 244 refs.

Abstract Background and objective Tauopathy is a group of neurodegenerative diseases in which the pathogenesis processes are related to tau protein. The imbalances between activities kinases phosphatases protein lead hyperphosphorylation subsequent neurodegeneration. Numerous studies suggest strong linkage type 2 diabetes mellitus (T2D) diseases. Therefore, finding drug with dual therapeutic activity against T2D neuroprotective will be promising idea. Hence, potential effect Glimepiride...

Quinoline-2-carbohydrazide (3) was reacted with aryl or alkyl isothiocyanates to give the corresponding quinoline thiosemicarbazides (4a–e). Cyclization of substituted sodium hydroxide led formation 5-(quinolin-2-yl)-2H-1, 2, 4-triazole-3(4H)-thiones (5a–e). Desulfurization by mercuric oxide gave 5-(quinolin-2-yl)-1, 3, 4-oxadiazol- 2-amines (6a–e). Treatment ethyl bromoacetate α -bromopropionic acid yielded (Z)-N′-(3-substituted thiazolidin-4-oxo-2-ylidene) quinoline-2-carbohydrazides...

Abstract magnified image Reaction of visnaginone which derived from the naturally occurring compound “visnagine”, with allyl bromide gave O ‐allyl 1 , underwent Claisen rearrangement to yield 7‐allylbenzofuran 2 derivative. Vilsmeier Haack formylation afforded our versatile starting furochromene‐6‐carboxaldehyde ( 3 ) was condensed cyclohexane‐1,3‐dione, indandione, malononitrile or ethyl cyanoacetate ylidene nicotinonitrile and pyridone derivatives 4,7,10a‐b . aniline acting on multiple...

A new promising protocol has been developed for the synthesis of scarce oxocine derivatives 3a-e and 6 through addition amine-based nucleophiles such as hydroxylamine hydrochloride, primary amine hydrazide to chromonylidene benzothiazol-2-ylacetonitrile 2 in refluxing dioxane under metal free reaction conditions moderate good yields. Other nitrogen piperidine, hydrazine thiosemicarbazide failed afford corresponding oxocinols, instead pyridine 7, 8 10 were obtained exclusively. Predictive...

Abstract This study is directed towards the synthesis of pyrrolo[1,2‐α]indole skeleton which essential ring system active antitumor miomycins. To this end a number fused heterocycles such as benzothiazines, benzoxazines, indoles and quinolines were synthesized. The structures new compounds assigned by ir, 1 H nmr ms‐data.

A range of heterocyclic systems incorporating chromone and related scaffolds was synthesized via domino reactions 3‐vinylchromone. These cascade processes resulted in the construction various nuclei such as xanthone enaminone well diazolo triazolo chomenopyrimidine heterocycles.

Abstract The aim of this study involves the synthesis novel heterocyclic scaffolds containing quinoline moiety and studying their role as antimicrobial agents. 4‐hydroxy‐6‐phenyl‐2 H ‐pyrano[3,2‐ c ]quinoline‐2,5(6 ))‐dione ( 1 ) was utilized a precursor for construction new polyheterocyclic ring systems. It reacted with three aryl (heteroaryl) aldehydes to furnish corresponding arylidenes 2a ‐ . nucleophilic cyclization compound 2 hydrazine hydrate give pyrazolyl quinolinone 3 Moreover,...

This review presents the chemistry of quinacetophenone and its utility as an easily accessible building block for synthesis various advantageous organic compounds. versatile precursor can be synthesized via different synthetic methodologies such Friedel–Crafts acetylation, Fries rearrangement Hoesch reaction. Based upon inherent chemical reactivity, title compound has been utilized to construct molecules chalcones, chromones, flavonoids, coumarins, quinones azoles including naturally...

Abstract magnified image Reaction of visnaginone 1 with allyl bromide gave O ‐allyl 2 which underwent Claisen rearrangement to yield 7‐allylbenzofuran derivative 3 . different aromatic aldehydes the corresponding 5‐cinnamoylbenzofuran derivatives 4a‐d Condensation latter chalcones 4a,c,d hydrazine hydrate and phenylhydrazine provided, pyrazoline 7a‐f condensation compound ethyl acetate diethyl carbonate afforded adducts 8 12 easily cyclized 9 13 , are endowed interesting biological properties.