A5009516124- RNA modifications and cancer
- Regulation of Appetite and Obesity
- RNA and protein synthesis mechanisms
- Cystic Fibrosis Research Advances
- Cancer-related molecular mechanisms research
- Acute Myeloid Leukemia Research
- Pancreatic function and diabetes
- Genetic factors in colorectal cancer
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Cell Adhesion Molecules Research
- Biochemical Analysis and Sensing Techniques
- Platelet Disorders and Treatments
- Olfactory and Sensory Function Studies
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
University of Catania
2019-2024
Chromosomal instability is a hallmark of colorectal carcinogenesis and produces an accumulation different forms aneuploidies or broad copy number aberrations. Colorectal cancer characterized by gain-type aberrations, specifically in Chr20, Chr8q, Chr13 Chr7, but their roles mechanisms progression are not fully understood. It has been suggested that gains might contribute to tumor development through the so-called caricature transcriptomic effect. We intend investigate impact on long...
Conventional chemotherapy for acute myeloid leukemia regimens generally encompass an intensive induction phase, in order to achieve a morphological remission terms of bone marrow blasts (<5%). The majority cases are classified as Primary Induction Response (PIR); unfortunately, 15% children do not and defined Failure (PIF). This study aims characterize the gene expression profile PIF with Acute Myeloid Leukemia (AML), detect molecular pathways dysfunctions identify potential biomarkers....
Protease temporary inhibitors are true substrates that bind the catalytic site with high affinity but slowly degraded, thus acting as inhibitor for a defined time window. Serine peptidase Kazal type (SPINK) family is endowed such functional property whose physiological meaning poorly explored. High expression of SPINK2 in some hematopoietic malignancies prompted us to investigate its role adult human bone marrow. We report here stem and progenitor cells (HSPCs) mobilized cluster...