A5030834735- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Biochemical Analysis and Sensing Techniques
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Regulation of Appetite and Obesity
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Urological Disorders and Treatments
- Chemical Analysis and Environmental Impact
- Protein Degradation and Inhibitors
- Child Nutrition and Feeding Issues
- Ion channel regulation and function
- Genetic Syndromes and Imprinting
- Per- and polyfluoroalkyl substances research
- Infant Development and Preterm Care
- Glutathione Transferases and Polymorphisms
- Olfactory and Sensory Function Studies
- CRISPR and Genetic Engineering
- Birth, Development, and Health
- RNA Research and Splicing
- Diabetes Treatment and Management
- Diabetes Management and Research
- Neuroscience and Neuropharmacology Research
The Ohio State University
2024
National Research Council
2024
Institute for Biomedical Research and Innovation
2024
The Ohio State University Wexner Medical Center
2024
University of Catania
2019-2023
Italian Institute of Technology
2016-2017
KDM2B is a JmjC domain lysine demethylase, which promotes cell immortalization, stem self-renewal and tumorigenesis. Here we employed multi-omics strategy to address its role in ribosome biogenesis mRNA translation. These processes are required sustain proliferation, an important cancer hallmark. Contrary earlier observations, by stimulating the transcription of genes encoding factors ribosomal proteins, particularly those involved 40S subunits. Knockdown impaired assembly small large...
Abnormal feeding behavior is one of the main symptoms Prader-Willi syndrome (PWS). By studying a PWS mouse mutant line, which carries paternally inherited deletion small nucleolar RNA 116 (Snord116), we observed significant changes in working-for-food behavioral responses at various timescales. In particular, report that mice show delay compared to wild-type littermate controls responding both hour-scale and seconds-to-minutes-scale time intervals. This timing shift associated with better...
to evaluate the risk profile of hypospadias in Gela, an Italian National Priority Contaminated Site (NPCS) located Sicily Region (Southern Italy), characterized by a significant excess newborn residents compared data from reference on regional, national, and international basis and, until 2014, presence petrochemical plant.
Abstract Nucleoli are large nuclear sub-compartments where vital cellular processes, such as rRNA production and ribosome assembly, take place. Aggressive tumor types, Triple Negative Breast Cancer (TNBC), require increased biogenesis to support their enhanced proliferation. Therefore, it has been suggested that the nucleolus could be a valid anti-neoplastic target. However, we still have limited understanding of cancer-specific functions nucleolar components, preventing effective...
Multi-layer Complex networks are commonly used for modeling and analysing biological entities. This paper presents the advantage of using COMBO (Combining Multi Bio Omics) to suggest a new role chromosomal aberration as cancer driver factor. Exploiting heterogeneous multi-layer networks, integrates gene expression DNA-methylation data in order identify complex bilateral relationships between transcriptome epigenome. We evaluated generated by on different TCGA datasets (COAD, BLCA, BRCA,...
Nucleoli are large nuclear sub-compartments where vital processes, such as ribosome assembly, take place. Technical obstacles still limit our understanding of the biological functions nucleolar proteins in cell homeostasis and cancer pathogenesis. Since most essential, their abrogation cannot be achieved through conventional approaches. Additionally, activities many connected to physiological concentration. Thus, artificial overexpression might not fully recapitulate endogenous functions....
KDM2B encodes a JmjC domain-containing histone lysine demethylase, which functions as an oncogene in several types of tumors, including TNBC. This study was initiated to address the cancer relevance results our earlier work, had shown that overexpression renders mouse embryonic fibroblasts (MEFs) resistant oxidative stress by regulating antioxidant mechanisms.
Abstract Our earlier studies had shown that overexpression of the JmjC domain histone demethylase KDM2B renders mouse embryo fibroblasts (MEFs) resistant to oxidative stress due role in regulation antioxidant mechanisms. Here we present evidence knockdown basal-like breast cancer cell lines results a decrease Glutathione (GSH) levels, secondary increase intracellular ROS levels and enhanced sensitivity deubiquitinase inhibitors. The expression Glutamate-Cystine antiporter, Glutamate-Cysteine...