Tonia Luca

ORCID: 0000-0001-6109-5005
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About
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Research Areas
  • Cardiovascular Disease and Adiposity
  • Genetic factors in colorectal cancer
  • Adipose Tissue and Metabolism
  • Cancer Genomics and Diagnostics
  • Phytochemistry and Biological Activities
  • Coronary Artery Anomalies
  • Essential Oils and Antimicrobial Activity
  • Colorectal Cancer Treatments and Studies
  • Natural product bioactivities and synthesis
  • HER2/EGFR in Cancer Research
  • Monoclonal and Polyclonal Antibodies Research
  • Cardiovascular Effects of Exercise
  • Urological Disorders and Treatments
  • Adipokines, Inflammation, and Metabolic Diseases
  • Cardiac tumors and thrombi
  • Genomic variations and chromosomal abnormalities
  • Regulation of Appetite and Obesity
  • Diet, Metabolism, and Disease
  • Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Kawasaki Disease and Coronary Complications
  • Biochemical Analysis and Sensing Techniques
  • PARP inhibition in cancer therapy
  • Lymphatic System and Diseases
  • Cardiac Structural Anomalies and Repair

University of Catania
2007-2025

Istituto di Studi sul Mediterraneo (CNR - ISMed)
2015-2025

Clinica Mediterranea
2008-2020

The San Raffaele Telethon Institute for Gene Therapy
2005

Objective: To investigate the in vitro antiproliferative action of essential oil from Salvia officinalis L. (S. officinalis) grown Sicily (Italy), and its main components on hormone-dependent cancer cell lines. Methods: S. was prepared by hydrodistillation. The actions three principal ( α -thujone, 1,8-cineole camphor) were evaluated LNCaP cells (prostate carcinoma), MCF7 (breast carcinoma) HeLa (cervical at various dosages diverse time points. Cell viability proliferation estimated using...

10.4103/2221-1691.250266 article EN cc-by-nc-sa Asian Pacific Journal of Tropical Biomedicine 2019-01-01

The teaching of human anatomy is experiencing significant transformation. Particularly in recent years, incorporating new digital technologies has drastically changed the approach to education. Our bibliometric study aims investigate trends and issues from 2004 2024 related technology teaching. publication trend field steadily increased over peaking 2022 declining 2023. Despite limited statistics for 2024, we do not project an exponential increase publications. Co-citation analysis...

10.3390/educsci15030346 article EN cc-by Education Sciences 2025-03-11

Abstract Objective This study aimed to evaluate adipose tissue of lipedema patients. Methods Gluteo‐femoral (affected area) and interscapular (nonaffected from 10 lean patients affected by stage 1 2 was studied compared with obesity 12 Results The main features were alterations capillaries wall thickening ( p ≤ 0.0001), endothelial pericyte hyperplasia = 0.03 0.004), hypodense areas in basal membrane, degeneration exfoliation degenerated cells into the capillary lumen. Adipocytes larger...

10.1002/oby.24244 article EN cc-by Obesity 2025-03-12

Abstract Background: Artificial intelligence (AI) incorporation into healthcare has proven revolutionary, especially in radiotherapy, where accuracy is critical. The purpose of the study to present patterns and develop topics application AI improve precision anatomical diagnosis, delineation organs, therapeutic effectiveness radiation radiological imaging. Methods: We performed a bibliometric analysis scholarly articles fields starting 2014. Through an examination research output from key...

10.1088/2516-1091/adc85e article EN Progress in Biomedical Engineering 2025-04-02

Background/Objectives: Colorectal cancer is the third most common worldwide, making lymph node recovery critical for treatment decisions and prognosis. The relationship between body mass index (BMI) number of nodes retrieved during laparoscopic open surgeries remains controversial. This study aimed to evaluate whether surgical approach BMI influence retrieval in colon surgeries. Methods: A retrospective analysis was conducted on 560 patients who underwent surgery at a single institution 2018...

10.3390/cancers17081312 article EN Cancers 2025-04-14

Axonal transport of the lysosomal enzyme arylsulfatase A (ARSA) may be an additional mechanism distribution after in vivo brain gene transfer animal model metachromatic leukodystrophy (MLD). Direct molecular demonstration movement this within axonal networks was missing. We generated lentiviral vectors carrying ARSA cDNA tagged with hemagglutinin or green fluorescent protein and examined subcellular localization anatomical enzymes MLD hippocampus transfer. The use allowed direct real-time...

10.1016/j.ymthe.2005.06.438 article EN cc-by-nc-nd Molecular Therapy 2005-08-09

Overexpression or constitutive activation of epidermal growth factor receptors (EGFR) is involved in human cancers. We investigated effects EGFR and HER-2 blockade colon cancer cell lines using cetuximab trastuzumab, with the aim developing novel approaches to therapy.We studied treatment on growth, cycle distribution, induction apoptosis, changes mRNA-protein expression gene copy number Caco-2, HT-29 HCT-116 cells.Treatment cells resulted no effect one three inhibition proliferation a time-...

10.1111/cpr.12125 article EN Cell Proliferation 2014-08-08

Abstract Colon cancer is one of the most common human malignancies, and chemotherapy cannot yet prevent recurrence in all patients. Essential oils are phytocomplexes with antiproliferative properties. In this study, we elucidated properties effect on cell cycle progression Sicilian Salvia officinalis essential oil its three main compounds, α ‐thujone, 1,8‐cineole (eucalyptol) camphor, colon lines. The was obtained by hydrodistillation analyzed gas chromatography. Cell proliferation evaluated...

10.1002/cbdv.202000309 article EN Chemistry & Biodiversity 2020-06-12

Abstract In this article, we describe two cases of anomalous connection the left coronary artery. The first case is an infant 4 years with origin anterior descending (LAD) artery and diagonal branches a circumflex which originated from pulmonary second adult 50 originating Anomalous uncommon congenital cardiac anomaly incidence 0.25% among all heart defects (Parale Pawar [ 2006 ], J Assoc Physicians India 54:397–399). originality communication consists in use multislice CT scanner as support...

10.1002/ca.20618 article EN Clinical Anatomy 2008-04-21

Ureteral atresia is a rare disease usually associated with non-functioning kidney. Its association other urinary anomalies rare.In this study we discuss the possibility of congenital or acquired etiology right imperforate distal ureter. Here report case 11-month-old white boy ureteropelvic junction obstruction. He underwent pyeloplasty when he was 11-months old, and 3 weeks after surgery cystoscopy performed. Two months first operation, ureteral meatoplasty new pyeloplasty.To best our...

10.1186/s13256-015-0711-8 article EN cc-by Journal of Medical Case Reports 2015-10-02

We present an arthroscopic technique used to treat traumatic shoulder instability in the patient with a Hill-Sachs lesion, especially off-track lesion. The incidence of this bony defect is approximately 40% 90% all anterior cases-and up 100% patients recurrent instability. Incorrect management humeral bone can lead treatment failure, and it essential define characteristics such as lesion's location, depth, width, orientation. Many open procedures have been described for surgical Using...

10.1016/j.eats.2022.08.046 article EN cc-by-nc-nd Arthroscopy Techniques 2022-11-18
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