A5004968003- Neuroinflammation and Neurodegeneration Mechanisms
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Crustacean biology and ecology
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- RNA and protein synthesis mechanisms
- Genetics and Neurodevelopmental Disorders
- Moyamoya disease diagnosis and treatment
- Renal and related cancers
- Nuclear Receptors and Signaling
- Neuropeptides and Animal Physiology
- Urinary and Genital Oncology Studies
- Hypothalamic control of reproductive hormones
- Neurological Disease Mechanisms and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Atmospheric chemistry and aerosols
- Bladder and Urothelial Cancer Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- Air Quality Monitoring and Forecasting
- Cancer Genomics and Diagnostics
Baylor College of Medicine
2024
The University of Texas at Austin
2019-2023
University of Notre Dame
2017-2022
Austin College
2021
University of Iowa Hospitals and Clinics
2020
University of Iowa
2018
Florida State University
2018
Duke University
2016-2017
Significance Mycobacteria use ESX systems to transport protein substrates across the cytoplasmic membrane. The ESX-1 system is required for mycobacterial pathogenesis in Mycobacterium tuberculosis ( M. tb ), cause of (TB). Differences expression genes encoding directly impacts transmission and virulence. Deletion exporters results reduced levels mycobacteria. Here, we define a fundamental mechanism regulation marinum , pathogenic species model . We demonstrate that transcriptional linked...
Pathogenic mycobacteria encounter multiple environments during macrophage infection. Temporally, the bacteria are engulfed into phagosome, lyse phagosomal membrane, and interact with cytosol before spreading to another cell. Virulence factors secreted by mycobacterial ESX-1 (ESAT-6-system-1) secretion system mediate essential transition from phagosome cytosol. It was recently discovered that also regulates gene expression in
Estrogens are a group of steroid hormones that promote the development and maintenance female reproductive system secondary sex characteristics. also modulate immune responses; estrogen loss at menopause increases risk inflammatory disorders. Elevated responses in brain can lead to affective behavioral changes, which characteristic menopause. Thus, here we examined whether estrogens sensitizes microglia, primary innate cell brain, leading changes behaviors. To test this question, adult...
Abstract Aging and reduced exposure to environmental microbes can both potentiate neuroinflammatory responses. Prior studies indicate that immunization with the immunoregulatory anti-inflammatory bacterium, Mycobacterium vaccae ( M. ), in aged rats limits neuroimmune activation cognitive impairments. However, mechanisms by which ameliorates age-associated “priming” whether microglia are a primary target remain unclear. Here, we investigated protects against morphological changes response...
WWOX gene loss-of-function (LoF) has been associated with neuropathologies resulting in developmental, epileptic, and ataxic phenotypes of varying severity based on the level dysfunction. biallelic germline variant p.Pro47Thr (P47T) causally a new form autosomal recessive cerebellar ataxia epilepsy intellectual disability (SCAR12, MIM:614322). This mutation affecting WW1 protein binding domain WWOX, impairs its interaction canonical proline-proline-X-tyrosine motifs partner proteins. We...
Medulloblastoma is the most common malignant pediatric brain tumor.Prior studies have concentrated their efforts studying four molecular subgroups: SHH, Wnt, group 3, and 4. SHH Wnt are driven by canonical pathways.Groups 3 4 highly metastatic associated with aberrations in epigenetic regulators.Recent developments field revealed that these subgroups not as homogenous previously believed.The objective of this study to investigate involvement somatic driver gene mutations medulloblastoma...
Pathogenic mycobacteria are bacteria that pose a large burden to human health globally. The ESX-1 secretion system is required for pathogenic survive within and interact with the host.
The subtidal crab Dyspanopeus sayi has a circadian rhythm in larval release with free-running period of 24.1 h. Under constant conditions, eggs hatch primarily the 4-h interval after time sunset. study tested new model for entrainment crabs, which proposes that female perceives environmental cycles and entrains endogenous embryos. Results verified D. sayi. Hatching by embryos collected from field when they had not yet developed eye pigments, were kept conditions attached to their mother,...
In the last two decades, discovery of various pathways involved in renal cell carcinoma (RCC) have led to development biologically-driven targeted therapies. Hypoxia inducible factors (HIFs), angiogenic growth factors, von Hippel-Lindau (VHL) gene mutations and oncogenic miRNAs play essential roles pathogenesis drug resistance clear carcinoma. These insights VEGF inhibitors, mTOR inhibitors immunotherapeutic agents which significantly improved outcomes patients with advanced RCC. HIF will be...
Marine and estuarine crabs brood attached eggs, which hatch synchronously releasing larvae at precise times relative to environmental cycles. The subtidal crab Dyspanopeus sayi has a circadian rhythm, in are released within the 4-h interval after time of ambient sunset. Previous studies demonstrated that rhythm can be entrained by light:dark cycle. Since also exposed temperature fluctuations, an unstudied question was whether could diel To answer this question, ovigerous D. were darkness...
497 Background: Neoadjuvant chemotherapy followed by cystectomy in MIBC is associated with improved survival compared to alone. Recent retrospective studies indicated that secondary (non-MIBC progressed MIBC) had worse outcome cisplatin based neoadjuvant when primary MIBC. To further evaluate this observation, we queried our database assess the differential response and determine if prior use of intravesical therapy diminishes effect chemotherapy. Methods: A total 387 patients diagnosed T...
ABSTRACT WWOX gene loss-of-function (LoF) has been associated with neuropathologies resulting in developmental, epileptic, and ataxic phenotypes of varying severity based on the level dysfunction. biallelic germline variant p.Pro47Thr (P47T) causally a new form autosomal recessive cerebellar ataxia epilepsy intellectual disability (SCAR12). This mutation affects WW1 protein binding domain WWOX, impairing its ability to interact canonical proline-proline-X-tyrosine motifs partner proteins. We...