A5010092514- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Protease and Inhibitor Mechanisms
- S100 Proteins and Annexins
- Kruppel-like factors research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- TGF-β signaling in diseases
- Biomarkers in Disease Mechanisms
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Immune Cell Function and Interaction
- Microbial metabolism and enzyme function
- Cancer, Hypoxia, and Metabolism
Centro de Investigación Biomédica en Red de Cáncer
2022-2024
Instituto de Investigación Sanitaria del Principado de Asturias
2023-2024
Universidad de Oviedo
2023-2024
Instituto de Salud Carlos III
2023-2024
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive cancer, with limited therapeutic options high mortality rate, primarily due to metastasis recurrence. Tumor-stroma interactions, namely cancer-associated fibroblasts (CAFs), are pivotal in shaping HNSCC progression. CAFs remodel the extracellular matrix (ECM) secrete factors vesicles that promote tumor growth metastasis. The interplay between autophagy endosomal/exosomal pathways has been suggested regulate cellular...
Cancer-associated fibroblasts (CAFs) are major players in tumor-stroma communication, and participate several cancer hallmarks to drive tumor progression metastatic dissemination. This study investigates the driving effects of tumor-secreted factors on CAF biology, with ultimate goal identifying effective therapeutic targets/strategies for head neck squamous cell carcinomas (HNSCC).Functionally, conditioned media (CM) from different HNSCC-derived lines normal keratinocytes (Kc) were tested...
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Lectin-like transcript-1 (LLT1) expression is detected in different cancer types and involved immune evasion. The present study investigates the clinical relevance of tumoral stromal LLT1 oral squamous cell carcinoma (OSCC), relationships with infiltrate into tumor microenvironment (TIME). Immunohistochemical analysis was performed 124 OSCC specimens, together PD-L1 infiltration CD20+, CD4+, CD8+ lymphocytes CD68+ CD163+-macrophages. Associations clinicopathological variables, prognosis,...
<b><i>Introduction:</i></b> Lysyl oxidase-like 2 (LOXL2) expression and function is frequently altered in different cancers but scarcely explored oral squamous cell carcinoma (OSCC). This prompted us to investigate the clinical relevance of LOXL2 pattern OSCC also a possible crosstalk with Hippo/YAP1 pathway signaling. <b><i>Methods:</i></b> Immunohistochemical analysis protein was performed 158 patient samples, together Yes-associated 1 (YAP1)...