A5006642631- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Neuroblastoma Research and Treatments
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
Tianjin Medical University Cancer Institute and Hospital
2024
Tianjin Medical University
2022-2024
Abstract Integrin alpha L (ITGAL), a member of the integrin family, is associated with carcinogenesis and immune regulation. However, biological functions ITGAL in lung adenocarcinoma (LUAD) remain poorly understood. In this study, we utilized TCGA dataset to analyse mRNA expression LUAD examined its correlation clinical prognosis. Three‐dimensional (3D) Matrigel culture, 5‐bromodeoxyuridine (BrdU) ELISA, wound‐healing migration cell adherence assays were used demonstrate potential role...
Abstract Lung adenocarcinoma (LUAD) generally presents as an immunosuppressive microenvironment. The characteristics of cell‐to‐cell communication in the LUAD microenvironment has been unclear. In this study, bulk RNA‐seq data and single‐cell were retrieved from public dataset. Differential expression genes (DEGs) between tumor adjacent non‐tumor tissues calculated by limma algorithm, then detected PPI, KEGG, GO analysis. Cell–cell interactions explored using data. Finally, first 15...
The switch from anchorage-dependent to anchorage-independent growth is essential for epithelial metastasis. underlying mechanism, however, not fully understood. In this study, we identified factor independent-1 (GFI1), a transcription that drives the transition adherent endothelial cells suspended hematopoietic during hematopoiesis, as critical regulator of anchorage independence in lung cancer cells. GFI1 elevated numbers circulating and lung-infiltrating tumor xenograft models predicted...