A5100369917- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Advanced Neuroimaging Techniques and Applications
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Point processes and geometric inequalities
- Alzheimer's disease research and treatments
Nanjing Medical University
2021
Suzhou Municipal Hospital
2021
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2021
Ischemic brain injury results in high mortality and serious neurologic morbidity. Here, we explored the role of SNHG15 modulating neuronal damage microglial inflammation after ischemia stroke.The hypoxia/ischemia models were induced by middle cerebral artery occlusion mice oxygen-glucose deprivation/reoxygenation (OGD/R) vitro. Quantitative real-time PCR (qRT-PCR) Western blot conducted to determine levels SNHG15, miR-302a-3p, STAT1/NF-κB. Moreover, gain- or loss-of functional assays...
Studies have provided qualitative evidence of de-myelination and re-myelination in aged brain white matter. However, there been no quantitative evidences degeneration regeneration myelin sheaths The present study was designed to investigate the changes using unbiased stereological techniques electron microscopy Results obtained showed that matter, total volume old-age female rats not significantly different from young rats, but length myelinated fibers old decreased by 46.1% when compared...