A5033411505- Parathyroid Disorders and Treatments
- Heterotopic Ossification and Related Conditions
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Metabolism, Diabetes, and Cancer
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Carcinogens and Genotoxicity Assessment
- Cancer therapeutics and mechanisms
- Anesthesia and Neurotoxicity Research
- Pomegranate: compositions and health benefits
- Natural Compounds in Disease Treatment
- Aluminum toxicity and tolerance in plants and animals
- CAR-T cell therapy research
- Cardiac Ischemia and Reperfusion
- Drug Transport and Resistance Mechanisms
- Heavy Metal Exposure and Toxicity
- Synthesis and bioactivity of alkaloids
- Nanowire Synthesis and Applications
- Aortic Thrombus and Embolism
- Chemotherapy-induced organ toxicity mitigation
- Microfluidic and Bio-sensing Technologies
- Cancer Research and Treatments
- Flavonoids in Medical Research
- Virus-based gene therapy research
Wroclaw Medical University
2021-2024
Ischemia/reperfusion injury (IRI) of the heart involves activation oxidative and proapoptotic pathways. Simultaneously Klotho protein presents anti-aging, antiapoptotic antioxidative properties. Therefore, this study aimed to evaluate effect on stress in hearts subjected IRI. Isolated rat perfused with Langendorff method were ischemia, followed by reperfusion, presence or absence recombinant protein. The factors involved insulin-like growth factor receptor (IGF1R)/phosphoinositide-3-kinase...
Obesity and metabolic syndrome (MetS) constitute a rapidly increasing health problem contribute to the development of multiple comorbidities like acute chronic kidney disease. Insulin resistance, inappropriate lipolysis, excess free fatty acids (FFAs) are associated with glomerulus hyperfiltration atherosclerosis. The important component MetS, oxidative stress, is also involved in destabilization function progression injury. Natural polyphenols have ability reduce harmful effect reactive...
Exposure to aluminum (Al) and its compounds is an environmental factor that induces neurotoxicity, partially through oxidative stress, potentially leading the development of neurodegenerative diseases. Components diet, such as caffeinated coffee, may play a significant role in preventing these In present study, experimental model PC12 cells (rat pheochromocytoma tumor cells) was developed investigate influence caffeine coffee on neurotoxicity induced by Al and/or stress. For induction...
Background: Colorectal cancer is one of the leading and most lethal neoplasms. Standard chemotherapy ineffective, especially in metastatic cancer, does not target stem cells. A promising approach to improve treatment combination therapy standard cytostatic drugs with natural compounds. Several plant-derived compounds have been proven possess anticancer properties, including induction apoptosis inhibition invasion. This study was focused on investigating vitro camptothecin (CPT) celastrol...
Colorectal cancers are one of the leading worldwide and known for their high potential metastasis resistance to therapy. The aim this study was investigate effect various combination therapies irinotecan with melatonin, wogonin, celastrol on drug-sensitive colon cancer cells (LOVO cell line) doxorubicin-resistant stem-like (LOVO/DX subline). Melatonin is a hormone synthesized in pineal gland responsible circadian rhythm. Wogonin natural compounds previously used traditional Chinese medicine....
CD19-targeted CAR-T cell therapy has revolutionized the treatment of relapsed/refractory (r/r) pre-B acute lymphoblastic leukemia (ALL). However, it can be associated with toxicities related to immune activation, particularly cytokine release syndrome (CRS) and effector cell-associated neurotoxicity (ICANS). Cytokines released from activated cells play a key role in their pathophysiology. This study was prospective analysis proinflammatory proteins cytokines children treated...
Transplanted organs are subjected to harmful conditions through stopping blood flow, hypothermic storage of the graft, and subsequent reperfusion. In particular, kidneys donated from patients after cardiac arrest (DCD) classified as more vulnerable ischemia-reperfusion injury (IRI). Hypothermic machine perfusion is proposed a solution for better kidney before transplantation, it good platform additional graft treatment. Antioxidants have gained interest in regenerative medicine due their...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Science Centre, Poland. Background The injury the myocardium during ischemia/reperfusion (IRI) involves metabolic, morphological and contractile disorders [1]. Klotho is a membrane or soluble anti-aging protein. Recent studies have proven correlation deficiency occurrence development cardiovascular diseases [2]. Purpose This study aimed to evaluate effect protein supply on...
Abstract Ischemia/reperfusion injury (IRI) of the heart involves activation oxidative and proapoptotic pathways. Simultaneously Klotho protein presents anti-aging, antiapoptotic antioxidative properties. Therefore, this study aimed to evaluate effect on stress in hearts subjected IRI. Isolated rat perfused with Langendorff method were ischemia, followed by reperfusion, presence or absence recombinant protein. The factors involved insulin-like growth factor receptor...
Abstract Background Ischemia/reperfusion injury (IRI) of heart involves activation oxidative and apoptotic pathways. Klotho protein has potential protective activity since it supports redox balance metabolic functions cardiomyocytes. This study aimed to evaluate effect on stress apoptosis in hearts subjected IRI. Material methods Isolated rat perfused with the Langendorff method were ischemia, followed by reperfusion, presence or absence protein. Heart mechanical function factors involved...