A5060682826- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Inflammatory mediators and NSAID effects
- Crystallization and Solubility Studies
- Synthesis and Characterization of Pyrroles
- Electrospun Nanofibers in Biomedical Applications
- Biochemical effects in animals
- Bone Tissue Engineering Materials
- X-ray Diffraction in Crystallography
- Tissue Engineering and Regenerative Medicine
- Bioactive Compounds and Antitumor Agents
- Phytoestrogen effects and research
- Facial Trauma and Fracture Management
- Additive Manufacturing and 3D Printing Technologies
- Adipose Tissue and Metabolism
- Infant Nutrition and Health
- Transgenic Plants and Applications
- Coconut Research and Applications
- Flavonoids in Medical Research
- Quinazolinone synthesis and applications
- Cancer Research and Treatments
- GABA and Rice Research
- Chemical synthesis and pharmacological studies
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
Wroclaw Medical University
2015-2024
National Institute of Standards and Technology
2023
Université de Lorraine
2023
Numerous studies have confirmed the coexistence of oxidative stress and inflammatory processes. Long-term inflammation may significantly affect initiation neoplastic transformation process. Here, we describe synthesis a new series Mannich base-type hybrid compounds containing an arylpiperazine residue, 1,3,4-oxadiazole ring, pyridothiazine-1,1-dioxide core. The was carried out with hope that hybridization different pharmacophoric molecules would result in synergistic effect on their...
Colorectal cancers are one of the leading worldwide and known for their high potential metastasis resistance to therapy. The aim this study was investigate effect various combination therapies irinotecan with melatonin, wogonin, celastrol on drug-sensitive colon cancer cells (LOVO cell line) doxorubicin-resistant stem-like (LOVO/DX subline). Melatonin is a hormone synthesized in pineal gland responsible circadian rhythm. Wogonin natural compounds previously used traditional Chinese medicine....
Polyunsaturated fatty acids, sterols, and hydrophilic phenolic compounds are components of flax oil that act as antioxidants. We investigated the impact from transgenic in form emulsions on stressed Chinese hamster pulmonary fibroblasts. found protect V79 cells against H 2 O effect is dose dependent. They reduced level intracellular reactive oxygen species protected genomic DNA damage. The rate cell proliferation increased upon treatment with at a low concentration, while high concentration...
Oxicams (e.g. piroxicam, meloxicam) are widely used nonsteroidal anti-inflammatory drugs (NSAIDs). A large body of evidence from epidemiological and preclinical studies has shown that NSAIDs have a chemopreventive effect on different types cancer, especially in colorectal cancer. Moreover, mounting clinical suggests persistent inflammation functions as driving force the journey to What is more, induces reactive oxygen nitrogen species, which cause damage important cellular components (e.g.,...
In the present paper, we describe biological activity of newly designed and synthesized series N-substituted 3,4-pyrroledicarboximides 2a–2p. The compounds 2a–2p were obtained in good yields by one-pot, three-component condensation pyrrolo[3,4-c]pyrrole scaffold (1a–c) with secondary amines an excess formaldehyde solution C2H5OH. structural properties characterized 1H NMR, 13C NMR FT-IR, MS, elemental analysis. Moreover, single crystal X-ray diffraction has been recorded for compound 2h....
Cyclooxygenase inhibitors as anti-inflammatory agents can be used in chemoprevention. Many vitro and vivo studies on human animal models have explained the mechanisms of chemopreventive effect COX such as: induction apoptosis, inhibition neoplasia, angiogenesis suppression, cell cycle expression peroxisome proliferator-activated receptors. Here, biological evaluation twelve different Schiff base derivatives N-(2-hydrazine-2-oxoethyl)-4,6-dimethyl-2-sulfanylpyridine- 3-carboxamide are...
The p53 protein is a transcription factor for many genes, including genes involved in inhibiting cell proliferation and inducing apoptosis genotoxically damaged tumor-transformed cells. In more than 55% of cases human cancers, loss the essential function found. numerous reports, it has been shown that small molecules (chemical compounds) can restore suppressor mutant tumor aim this study was to evaluate potential anticancer activity three newly synthesized olivacine derivatives.The performed...
Abstract This study investigated the effects of oxidative stress on cell viability (MTT test), free radicals (DCF-DA test) induction, and metabolomic profiles. Hydrogen peroxide was added to cultures human embryonic kidney line (HEK-293) African green monkey (COS-7), resulting in changes both extracellular intracellular metabolites. Metabolomic studies using nuclear magnetic resonance (NMR) showed consistent metabolites like glutamate, NAD+/NADH, glutathione, ATP, AMP, pyruvate, significant...
The use of extracellular matrix (ECM) biomaterials for soft tissue repair has proved extremely successful in animal models and some clinical settings. aim the study was to investigate effect commercially obtained CorMatrix bioscaffold on viability, proliferation migration rat pheochromocytoma cell line PC12. PC12 cells were plated directly onto a flake or well surface 12-well plate cultured RPMI-1640 medium supplemented with nerve growth factor (NGF). culture plates modified collagen type I...