A5014875002- Lipid Membrane Structure and Behavior
- Synthesis and biological activity
- Inflammatory mediators and NSAID effects
- Phenothiazines and Benzothiazines Synthesis and Activities
- Analytical Chemistry and Chromatography
- Phytoestrogen effects and research
- X-ray Diffraction in Crystallography
- Estrogen and related hormone effects
- Crystallization and Solubility Studies
- Advanced Fluorescence Microscopy Techniques
- Synthesis and Biological Evaluation
- Protein Interaction Studies and Fluorescence Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Quinazolinone synthesis and applications
- Drug Transport and Resistance Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Photodynamic Therapy Research Studies
- Antioxidant Activity and Oxidative Stress
- thermodynamics and calorimetric analyses
- Pharmacogenetics and Drug Metabolism
- Proteins in Food Systems
- Phytochemicals and Antioxidant Activities
- RNA Interference and Gene Delivery
- Nanopore and Nanochannel Transport Studies
Wroclaw Medical University
2008-2024
National Institute of Standards and Technology
2023
Université de Lorraine
2023
Model systems such as black lipid membranes or conventional uni- multilamellar liposomes are commonly used to study membrane properties and structure. However, the construction dimensions of these models excluded their direct optical microscopic observation. Since introduction simple method liposome electroformation in alternating electric field giant unilamellar vesicles (GUVs) have become an important model imitating biological membranes. Due average diameter GUVs reaching up 100 microm,...
Oxicams (e.g. piroxicam, meloxicam) are widely used nonsteroidal anti-inflammatory drugs (NSAIDs). A large body of evidence from epidemiological and preclinical studies has shown that NSAIDs have a chemopreventive effect on different types cancer, especially in colorectal cancer. Moreover, mounting clinical suggests persistent inflammation functions as driving force the journey to What is more, induces reactive oxygen nitrogen species, which cause damage important cellular components (e.g.,...
The purpose of the present paper was to assess ability five newly designed and synthesized meloxicam analogues interact with phospholipid bilayers. Calorimetric fluorescence spectroscopic measurements revealed that, depending on details chemical structure, studied compounds penetrated bilayers affected mainly their polar/apolar regions, closer surface model membrane. influence thermotropic properties DPPC clearly visible because these reduced temperature cooperativity main phase transition....
The purpose of the present work was to assess ability five new oxicam analogues interact with lipid bilayers. To characterize interaction newly synthesized NSAIDs (non-steroidal anti-inflammatory drugs) DPPC bilayers two following techniques were applied - differential scanning calorimetry (DSC) and fluorescence spectroscopy. results obtained by these experimental approaches show that oxicams model membranes under consideration. As demonstrated both in calorimetric spectroscopic studies,...
New, tricyclic compounds containing a sulfonyl moiety in their structure, as potential safer COX inhibitors, were designed and synthesized. New derivatives have three conjugated rings group. A third ring, i.e., an oxazine, oxazepine or oxazocin, has been added to the 1,2-benzothiazine skeleton. Their anti-COX-1/COX-2 cytotoxic effects vitro on NHDF cells, together with ability interact model membranes influence reactive oxygen species nitric oxide, studied. Additionally, molecular docking...
The drug interactions with the lipid membranes are crucial in many biochemical processes. Phospholipid model often used to assess such interactions. Our team has been researching new compounds anti-inflammatory and analgesic effects for years. Such derivatives of well-known non-steroidal (NSAID) - meloxicam (MLX). Their biological target is cyclooxygenase (COX) a membrane protein. NSAIDs mainly taken orally; therefore, drug-membrane interaction preliminary stage body.
The design of novel anti-inflammatory drugs remains a critical area research in the development effective treatments for inflammatory diseases. In this study, series 1,2-benzothiazine was evaluated through multifaceted approach. particular, we investigated potential interactions with lipid bilayers, an important consideration membrane permeability and overall pharmacokinetics. addition, their ability to inhibit cyclooxygenase 1 2 activity selectivity using both inhibition assay molecular...
The modified 1,2-benzothiazine analogues designed as new drug candidates and discussed in this paper are oxicam derivatives. Oxicams a class of non-steroidal anti-inflammatory drugs (NSAIDs). Their biological target is cyclooxygenase (COX), membrane protein associated with the phospholipid bilayer. In recent decades, it has been proven that effect NSAIDs may be closely related to their interaction at level membrane. These processes often complicated membranes themselves very complex....
Despite the widespread and easy access to NSAIDs, effective safe treatment of various inflammatory disorders is still a serious challenge because severe adverse effects distinctive these drugs. The Mannich base derivatives pyrrolo[3,4-c]pyrrole are potent, preferential COX-2 inhibitors with COX-2/COX-1 inhibitory ratio better than meloxicam. Therefore, we chose six most promising molecules subjected them further in-depth research. current study presents extensive biological, spectroscopic in...