A5055931810- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Nutrition, Genetics, and Disease
- Cancer Genomics and Diagnostics
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Genomic variations and chromosomal abnormalities
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Cancer Risks and Factors
- Epigenetics and DNA Methylation
- Coenzyme Q10 studies and effects
- Reproductive Physiology in Livestock
- Oral health in cancer treatment
- Vasculitis and related conditions
- Renal and related cancers
- Lung Cancer Treatments and Mutations
- Vitamin C and Antioxidants Research
- Renal cell carcinoma treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Multiple and Secondary Primary Cancers
- Stoma care and complications
- PI3K/AKT/mTOR signaling in cancer
Pomeranian Medical University
2004-2022
International Hereditary Cancer Center
2005-2008
In 1999 it has been recognized that 3 BRCA1 abnormalities - 5382insC, C61G and 4153delA constitute almost 90% of all germline mutations this gene in Poland. Due to the above findings we started performing cheap quick large scale testing for and, these days, have 4,000 carriers diagnosed under direct or indirect supervision what is probably largest number world. Additionally, results pushed us hypothesize genetic homogeneity will be seen Poland studies other genes. Actually, next allowed...
Patients with chronic inflammatory bowel disease (IBD) are at an increased risk of colorectal cancer (CRC) and it is estimated that one in six persons diagnosed IBD will develop CRC. This fact suggests genetic variations response genes may act as CRC modifiers. In order to test this hypothesis we investigated a series polymorphisms 6 (NOD2, DLG5, OCTN1, OCTN2, IL4, TNFα) associated the on group 607 consecutive newly patients compared results controls (350 newborns age, sex geographically...
Abstract The population frequencies of the CDKN2A common variants remain undetermined. In Poland, there is a variant CDKN2A: an alanine to threonine substitution (A148T), which has been detected in other populations. We have recently showed that it significantly overrepresented among Polish melanoma patients when compared general population. Herein, we ascertained prevalence A148T 3,583 unselected cancer cases and 3,000 random control subjects from same evaluated eleven different...
The NOD2 gene has been associated with susceptibility to Crohn's disease and individuals are at increased risk for cancer a number of organ sites. We studied the association between 3020insC allele among 2604 patients 1910 controls from Poland. Patients were diagnosed one twelve types in Szczecin region 1994 2004. Significant associations found colon (OR = 1.8; 95% CI 1.2 2.6), lung 1.7; 1.1 2.5) ovarian 1.6; 2.3). In addition, significant was early-onset laryngeal 2.9; 1.4 6.2) breast...
Ischaemia-reperfusion injury (IRI) is a factor leading to the damages of transplanted kidney, what affects mainly proximal tubules. Early monitoring tubule damage can be an efficient tool predict allograft dysfunction. Present in tubules, N-acetyl-beta-glucosaminidase (NAG) lysosomal enzyme whose excretion rises as result IRI or acute rejection. The aim this study was monitor NAG urine activity evaluate early damage, and try long-term function kidney.The enrolled 87 Caucasian renal...
Familial breast cancer was first recognized in the Roman medical literature of 100 AD [1]. The documentation familial clustering modern times published by Broca, who reported 10 cases 4 generations his wife's family [2]. In middle nineteen nineties it proven at molecular level that a substantial number and ovarian cancers has hereditary monogenic aetiology [3,4]. Evaluation frequency pedigree-clinical signs characteristic for strong aggregations breast/ovarian among consecutive these organs...
In this study, we examined whether the IL-8 content of urine sampled on day 1 and 14 after renal transplantation is a marker early long-term function. Moreover, assessed its concentration positively correlated with matrix metalloproteinase-9 (MMP-9) 30 12 months transplantation. Our analysis covered 87 patients who underwent kidney transplant. The were observed for an average (12–60 months). determined was significantly negatively creatinine clearance (on days 1, 7, 30), as well during...
Background: The authors assessed proximal renal tubular dysfunction and/or damage in pregnant women with various types of hypertension by measuring the three urinary lysosomal enzyme levels: N-acetyl-β-d-glucosaminidase (NAG), arylsulfatase A and β-glucuronidase. Methods: study consisted 120 divided into four groups: 41 20th week gestation or more, pregnancy-induced (PIH group), 28 after 20 weeks pregnancy pre-eclampsia (PE 21 chronic hypertension, identified before (CH group) 30 healthy,...
3020insC in the NOD2 gene increases risk of: • breast cancer DCIS below age 50 about 5-fold – this mutation is detected 8% of all cases, colorectal approximately 2-fold above 60 present 15% lung 12% ovarian 1.5-fold 11% cases [1, 2].
Introduction: Cardiac surgery associated AKI (CSA-AKI) complicates recovery and may be with a greater risk of developing chronic kidney disease mortality. The aim this study was to assess long-term clinical consequences transient increased activity urinary enzymes after cardiac (CS). Methods: An observational conducted in group 88 adult patients undergoing planned coronary artery bypass grafting (CABG), but all samples were obtained from 79 patients. enzymes: N-acetyl-beta-glucosaminidase...
Keywords: CDKN24, CHEK2, NOD2, cancer risk There is continuing interest in identifying low-penetrance genes which are associated with increased susceptibility to common types of cancer. There several approaches this problem, including the use chip-based single nucleotide polymorphism (SNP) arrays interrogate a large number simultaneously and pre-selecting candidate interest. Candidate for cancers particular site may be selected because they known predispose malignancies other organs,...
The aim of our study was to evaluate urinary excretion three brush border enzymes: gamma-glutamyl transferase, alanine aminopeptidase, and leucyl aminopeptidase in pregnant women with various types hypertensive disorders.The included 120 women, further subdivided into four groups: 41 at ≥ 20 weeks gestation gestational hypertension, 28 > pregnancy preeclampsia, 21 chronic hypertension identified 30 healthy controls.No significant differences levels all the enzymes were found between groups....