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Nicole Caccavo

ORCID: 0000-0003-1649-5557
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About
Contact & Profiles
A5076999179
Research Areas
  • Amyotrophic Lateral Sclerosis Research
  • Neurogenetic and Muscular Disorders Research
  • Neurological diseases and metabolism

Temple University
 2022

 Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease
OPENALEX - Publications 
Guillermo M. Alexander Terry Heiman‐Patterson Frank Bearoff Roger B. Sher Laura Hennessy and 5 more Shannon Terek Nicole Caccavo Gregory A. Cox Vivek M. Philip Elizabeth Blankenhorn

Amyotrophic lateral sclerosis (ALS) is the most common degenerative motor neuron disorder. Although cases of ALS are sporadic, 5–10% familial, with mutations associated over 40 genes. There variation symptoms within families carrying same mutation; disease may develop in one sibling and not another despite presence mutation both. cause this phenotypic unknown, it likely related to genetic modifiers expression. The identification causing genes has led development transgenic mouse models...

10.1371/journal.pone.0274615 article EN cc-by PLoS ONE 2022-09-15
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