A5073682138- Lung Cancer Research Studies
- RNA modifications and cancer
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Mast cells and histamine
- Polyamine Metabolism and Applications
- Cell Adhesion Molecules Research
- Cellular transport and secretion
- Adipokines, Inflammation, and Metabolic Diseases
- Circular RNAs in diseases
- Systemic Lupus Erythematosus Research
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Protease and Inhibitor Mechanisms
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- Integrated Circuits and Semiconductor Failure Analysis
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
University of Cologne
2020-2021
Universidade de São Paulo
2003-2018
National Council for Scientific and Technological Development
2018
National Sagamihara Hospital
2012
Universidade de Ribeirão Preto
2003
Loss of TP53 and RB1 in treatment-naïve small cell lung cancer (SCLC) suggests selective pressure to inactivate death pathways prior therapy. Yet, which these remain available SCLC is unknown. Here, through systemic analysis pathway availability SCLC, we identify non-neuroendocrine (NE) be vulnerable ferroptosis subtype-specific lipidome remodeling. While NE resistant, it acquires addiction the TRX anti-oxidant pathway. In experimental settings non-NE/NE intratumoral heterogeneity, non-NE or...
Abstract Background Colorectal cancer (CRC) is one of the most common cancers worldwide; it fourth leading cause death in world and third Brazil. Mutations APC, DCC, KRAS TP53 genes have been associated with progression sporadic CRC, occurring at defined pathological stages tumor consequently modulating several corresponding signaling pathways. Therefore, identification gene signatures that occur each stage during CRC critical can present an impact on diagnosis prognosis patient. In this...
Despite being a healthy tissue, the constituent cells of placenta, share similar characteristics with tumor cells, such as increased cell growth, migration, and invasion. However, while these processes are stochastic uncontrolled in cancer placenta they precisely controlled. Since miRNAs have been reported to regulate genes that control molecular mechanisms necessary for development both human cancer, we addressed highly expressed could be involved tumorigenesis. Here, assessed miRNA profile...
The current study examined the role of PLD2 in maintenance mast cell structure. Phospholipase D (PLD) catalyzes hydrolysis phosphatidylcholine to produce choline and phosphatidic acid (PA). PLD has two isoforms, PLD1 PLD2, which vary expression localization depending on type. line RBL-2H3 was transfected overexpress catalytically active (PLD2CA) inactive (PLD2CI) forms PLD2. results this show that PLD2CI cells have a distinct star-shaped morphology, whereas PLD2CA are spindle shaped. In...
Abstract Bi-allelic loss of TP53 and RB1 in treatment-naïve small cell lung cancer (SCLC) suggests strong selective pressure to inactivate regulated death pathways prior therapy. Yet, which remain available SCLC is unknown. Here, through systemic analysis pathway availability, we identify non-neuroendocrine (NE) NE subtypes segregate by their response ferroptosis, a recently described iron-dependent type necrosis. While that extrinsic apoptosis necroptosis are incapacitated, find non-NE be...
Abstract Adipose tissue has been classified based on its morphology and function as white, brown, or beige / brite. It plays an essential role a regulator of systemic metabolism through paracrine endocrine signals. Recently, multiple adipocyte subtypes have revealed using RNA sequencing technology, going beyond simply defined but by their cellular origin, adaptation to metabolic stress, plasticity. Here, we performed in-depth analysis publicly available single-nuclei RNAseq from adipose...