A5011685336- 3D Printing in Biomedical Research
- Advanced Drug Delivery Systems
- Additive Manufacturing and 3D Printing Technologies
- Diet and metabolism studies
- Pharmaceutical studies and practices
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Chemistry and Chromatography
- Adrenal Hormones and Disorders
- Autism Spectrum Disorder Research
- Sexual Differentiation and Disorders
- Computational Drug Discovery Methods
- biodegradable polymer synthesis and properties
- Biochemical effects in animals
- Hydrogels: synthesis, properties, applications
- Neuroscience and Neural Engineering
- Analytical Methods in Pharmaceuticals
- Restless Legs Syndrome Research
- Fluorine in Organic Chemistry
- Sleep and Wakefulness Research
- Tactile and Sensory Interactions
- Organic Chemistry Cycloaddition Reactions
- Diabetes Treatment and Management
- Pharmacology and Obesity Treatment
- Interactive and Immersive Displays
- Sleep and related disorders
National and Kapodistrian University of Athens
2022-2025
Three-dimensional (3D) printing is quickly being adopted in pharmaceutics due to the many advantages it offers, including treatment, adaptability, reduction waste and accelerated development of new formulations. In this study, micro-extrusion was implemented for production modified-release hydrocortisone (HCT) mini-tablets paediatric patients. For developed formulations, Gelucire® 44/14 Precirol® ATO 5 were used as main inks at three different ratios: 70%/30%, 60%/40% 50%/50%, respectively....
Biodegradable polyesters have been researched intensively over the last two decades because of their biodegradability and superb physical properties. However, use linear biodegradable polyesters, for preparation drug delivery systems (DDS), is hampered by several limitations. In view this, scientific attention has shifted to employment branched-chain (co-)polymers. this context, we present herein development new melatonin (MLT) tablet formulations, using novel branched polylactide...
Obesity is a complex condition characterized by excessive fat accumulation, leading to significant health risks, including cardiovascular diseases, diabetes, and certain cancers. Its multifactorial etiology encompasses genetic predispositions, behavioral factors, like poor eating habits sedentary lifestyles, hormonal imbalances involving leptin insulin resistance. In addition lifestyle interventions, such as balanced diets regular physical activity, pharmacological therapies play pivotal...
The anionic polymer sodium alginate, a linear copolymer of guluronic and mannuronic acids, is primarily present in brown algae. Copolymers are used the alginate preparation process to confer on material strength flexibility. Micelles other polymeric nanoparticles frequently made using triblock Pluronic® F-127. purpose study determine effect alginate’s viscosity (low medium) presence F-127 micelles swelling behavior prepared pure beads those loaded with micelles. nanomicelles have size 120...
An innovative approach for creating customized dosage forms and supporting patient populations with specific requirements who need additional support to improve drug adherence is 3D printing. This work introduces liquid crystal display (LCD) printing as a means of developing melatonin (MLT) tablets. For patients are blind or visually challenged, Braille patterns were displayed on the tablet surface in addition optimization hydrogel inks. Owing great accuracy, could validate that provided...
3D printing has been introduced as a novel approach for the design of personalized dosage forms and support patient groups with special needs that require additional assistance enhanced medication adherence. In this study liquid crystal display (LCD) is development sustained release bupropion
Introduction: In an attempt to circumvent the lipophilicity burden for oral administration of new potent synthetic melatoninergic fluorine-substituted methoxyphenylalkyl amides, we conducted in vitro modified release studies using carefully selected matrix tablets’ biopolymeric materials different ratios. Method: particular, sought attain profiles these analogues similar that parent compound, chronobiotic hormone Melatonin (MLT), and also commercially available drug, Circadin®. Result: It...
We report herein on the design and development of matrix tablets containing potent synthetic melatonin (MLT) receptor analogues, x-fluoro-y-methoxy substitiuted phenylalkylamides (compounds I-IV), preparation melatoninergic potency which was recently communicated. > Methods: The presence fluorine atom in compounds I-IV, besides not affecting their binding affinity, compared to pineal hormone melatonin, it also slows down metabolism, is a major drawback MLT. However, as increases...
Compounded medicinal products containing bupropion hydrochloride (BUP·HCl) and naltrexone (NTX·HCl) are available as adjunct therapy for the management of weight in obese/overweight adults. The present work describes development validation a novel RP-HPLC method simultaneous quantitation during dissolution both drugs from compounded bilayer composition tablets. involves Nucleosil 100-3 C-18 column (4.6 × 150 mm) mobile phase 70%/30% v/v ACN/KH2PO4·H2O aqueous solution 5 mM concentration....
In our ongoing attempt to develop oral melatonin (MLT) solid dosage forms for the treatment of either sleep onset or maintenance dysregulations, we have been experimented with a plethora biopolymers diverse structural features. this study present findings on MLT's modified release in aqueous media, from polycaprolactone (PCL) and its copolymers, methoxy poly(ethylene glycol)-co-PCL (mPEG-PCL), glycerol-co-PCL (GLY-PCL), pentaerythritol-co-PCL (PE-PCL), enriched excipients, such as...
The growth of the global population together with several unpredicted crises such as political, health, and financial, create an environment uncertainty in which social innovations can be developed to offer stability people’s lives new business development opportunities for benefit economy society. One undoubted rights every human being is access affordable medical treatment. However, costs time needed research on or specialized drugs are not often covered by governmental budgets initiatives...