A5024262234- biodegradable polymer synthesis and properties
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Polymer crystallization and properties
- Polymer Nanocomposites and Properties
- Graphene and Nanomaterials Applications
- Carbon dioxide utilization in catalysis
- Advanced Polymer Synthesis and Characterization
- Nanoparticles: synthesis and applications
- Nanocomposite Films for Food Packaging
- Biochemical effects in animals
- Ocular Surface and Contact Lens
- Hydrogels: synthesis, properties, applications
- Bone Tissue Engineering Materials
- Natural Fiber Reinforced Composites
- Pharmaceutical and Antibiotic Environmental Impacts
- Dendrimers and Hyperbranched Polymers
- Polymer Science and PVC
- Pomegranate: compositions and health benefits
- Muscle metabolism and nutrition
- Ionic liquids properties and applications
- Sleep and related disorders
- Mesoporous Materials and Catalysis
Aristotle University of Thessaloniki
2017-2025
The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release iron-chelating drug. Drug nanoencapsulation performed via ionic gelation using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles a size ranging between 150 and 400 nm were prepared neat CS/TPP 2/1 molar ratio while their yield directly dependent on the applied stirring rate during preparation process. DFO at different content (20, 45 75 wt %)...
The aim of the present work is to evaluate preparation sunscreen emulsions based on chitosan (CS) nanoparticles with annatto, ultrafiltrated (UF) saffron, and saffron. Ionic gelation was used for nanoparticles, while their morphological characteristics physicochemical properties were evaluated via Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), dynamic light scattering (DLS). Results showed that prepared ranged from ~150...
The main purpose of this study was to investigate the synthesis some cross-linked carboxyl-grafted chitosan derivatives be used as selective adsorbents for diclofenac (DCF) pharmaceutical compounds from aqueous mixtures. Four different materials were synthesized using succinic anhydride (CsSUC), maleic (CsMAL), itaconic acid (CsITA), and trans-aconitic (CsTACON) grafting agents. After synthesis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray...
The aim of this work was to evaluate the effectiveness neat chitosan (CS) and its derivatives with 2-acrylamido-2-methyl-1-propanesulfonic acid (AAMPS) [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (MEDSP) as appropriate nanocarriers for simultaneous ocular administration dexamethasone sodium phosphate (DxP) chloramphenicol (CHL). CS-AAMPS CS-MEDSP have been synthesized by free-radical polymerization their structure has proved Fourier-Transformed Infrared Spectroscopy...
Mesoporous silica-based nanoparticles (MSNs) are considered promising drug carriers because of their ordered pore structure, which permits high loading and release capacity. The dissolution Si Ca from MSNs can trigger osteogenic differentiation stem cells towards extracellular matrix calcification, while Mg Sr constitute key elements bone biology metabolism. aim this study was the synthesis characterization sol–gel-derived co-doped with Ca, Sr. Their physico-chemical properties were...
In this study, mesocellular silica foam (MCF) was used to encapsulate paliperidone, an antipsychotic drug in patients suffering from bipolar disorder. MCF with the adsorbed further encapsulated into poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) 75/25 w/w microspheres these have been coated thiolated chitosan. As found by TEM analysis, chitosan formed a thin layer on polymeric microspheres' surface order enhance their mucoadhesiveness. These aimed at intranasal delivery of...
The present study evaluates the preparation of risperidone controlled release microspheres as appropriate long-acting injectable formulations based on a series novel biodegradable and biocompatible poly(lactic acid)⁻poly(propylene adipate) (PLA/PPAd) polymer blends. Initially, PPAd was synthesized using two-stage melt polycondensation method (esterification polycondensation) characterized by 1H-NMR, differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) analyses. DSC XRD...
Intending to expand the thermo-physical properties of bio-based polymers, furan-based thermoplastic polyesters were synthesized following melt polycondensation method. The resulting namely, poly(ethylene 2,5-furandicarboxylate) (PEF), poly(propylene (PPF), poly(butylene (PBF) and poly(1,4-cyclohexanedimethylene (PCHDMF) are used in blends together with various polymers industrial importance, including terephthalate) (PET), 2,6-naphthalate) (PEN), poly(L-lactic acid) (PLA) polycarbonate (PC)....
Over the last several years, trend of researchers has been to use some very low-cost materials as adsorbents. For this purpose, already commercially used bast fibers were selected potential adsorbent remove basic dye from synthetic effluents. The adsorption yellow 37 was studied using three different under names flax, ramie, and kenaf. Their morphological structure examined techniques such scanning electron microscopy (SEM), crystallinity, X-Ray diffraction (XRD) Fourier transform infrared...
(1) Background: A proposed approach to promote periodontal tissue regeneration in cases of peri-implantitis is the local administration growth factors at implant site. Recombinant human bone morphogenetic protein-2 (rh-BMP-2) can effectively and osseointegration development appropriate carriers for its delivery paramount importance. The aim present study was develop SBA-15 mesoporous nanoparticles (MSNs) with varying porosity, evaluate their biocompatibility Periodontal Ligament Cells...
Biodegradable polyesters have been researched intensively over the last two decades because of their biodegradability and superb physical properties. However, use linear biodegradable polyesters, for preparation drug delivery systems (DDS), is hampered by several limitations. In view this, scientific attention has shifted to employment branched-chain (co-)polymers. this context, we present herein development new melatonin (MLT) tablet formulations, using novel branched polylactide...
We prepared and studied a series of triblock copolymers based on poly(ethylene glycol) (PEG) poly(lactic acid) (PLA). PLA blocks were in situ by ring-opening polymerization (ROP) lactide (LA) onto the two sites PEG. While our recent work similar with varying LA/PEG molar ratios fixed PEG [Bikiaris, N. D. Mater. Today Commun. 2024, 38, 107799], herein, we kept this ratio quite low, at 640/1, employed different molecular weights, Mn, initial 1, 4, 6, 8 kg/mol. The triblocks demonstrated high...
In the present study, a chitosan (CS) derivative with 2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SDAEM) zwitterionic monomer was prepared through chemical modification. The successful synthesis of CS-SDAEM confirmed by Fourier-transform Infrared (FTIR) and Nuclear Magnetic Resonance (1H-NMR) spectroscopies. Its crystallinity studied X-ray Diffraction (XRD), while in vitro cytotoxicity cell viability assays established its biocompatibility. Filtered fresh pomegranate...
In the present study, a series of aliphatic polyesters based on succinic acid and several diols with 2, 4, 6, 8, 10 methylene groups, namely poly(ethylene succinate) (PESu), poly(butylene (PBSu), poly(hexylene (PHSu), poly(octylene (POSu), poly(decylene (PDeSu), were prepared via two-stage melt polycondensation method. All semicrystalline materials Tm ranging from 64.2 to 117.8 °C, while their Tg values progressively decreasing by increasing group number in used diols. Thermogravimetric...
In the present work, porous metal-organic framework (MOF) Basolite®F300 (Fe-BTC) was tested as a potential drug-releasing depot to enhance solubility of anticancer drug paclitaxel (PTX) and prepare controlled release formulations after its encapsulation in amphiphilic methoxy poly(ethylene glycol)-poly(ε-caprolactone) (mPEG-PCL) nanoparticles. Investigation revealed that adsorption Fe-BTC reached approximately 40%, relatively high level, also led an overall amorphization confirmed by...
The synthesis, structure, crystallization, semicrystalline morphology and molecular mobility of renewable/biodegradable block copolymers based on poly(butylene adipate) poly(<sc>l</sc>-lactic acid).
Synthesis, crystallization and molecular dynamics investigation on PCL-based star-like block copolymers, with different alcohols used as multifunctional initiators, for biomedical applications.