A5045442635- Pharmaceutical Practices and Patient Outcomes
- Innovations in Medical Education
- Antibiotics Pharmacokinetics and Efficacy
- PARP inhibition in cancer therapy
- Pharmaceutical studies and practices
- DNA Repair Mechanisms
- Pneumonia and Respiratory Infections
- Pancreatitis Pathology and Treatment
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal disorders and treatments
- Global Health Workforce Issues
- Venous Thromboembolism Diagnosis and Management
- Medical Education and Admissions
- Cardiac electrophysiology and arrhythmias
- Problem and Project Based Learning
- Redox biology and oxidative stress
- Patient Safety and Medication Errors
- Autophagy in Disease and Therapy
- Pancreatic and Hepatic Oncology Research
- Global Health and Surgery
- Glutathione Transferases and Polymorphisms
- Pharmacy and Medical Practices
- Health Systems, Economic Evaluations, Quality of Life
- Cancer therapeutics and mechanisms
- Cystic Fibrosis Research Advances
Loma Linda University
2018-2025
UPMC Hillman Cancer Center
2022-2023
Cancer Research Center
2022-2023
University of Pittsburgh
2022-2023
Magee-Womens Research Institute
2022-2023
American College of Clinical Pharmacy
2023
University of Pittsburgh Medical Center
2022
Northern Health
2018
University of Utah
2018
The University of Queensland
2017
Abstract Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum activity and excellent tolerability. β‐lactams are well established display time‐dependent bactericidal activity, where reductions burden directly associated with time that free drug concentrations above minimum inhibitory concentration (MIC) pathogen during dosing interval. In an effort take advantage these characteristics, prolonged (extended continuous)...
Limited available evidence comparing DOACs with warfarin suggests efficacy and safety of for CVT. We aimed to evaluate whether a specific DOAC is preferred the treatment This retrospective cohort study included adult patients CVTs between September 2018 2022 treated DOAC. The primary outcome was rate partial or complete recanalization. Secondary outcomes recurrent VTE, CVT extension, major clinically relevant non-major bleeding, death within 180 days after initiation. Of 31 CVT, 21 received...
RAD51 is a critical recombinase that functions in concert with auxiliary mediator proteins to direct the homologous recombination (HR) DNA repair pathway. We show Cys319 possesses nucleophilic characteristics and important for irradiation-induced foci formation resistance inhibitors of poly (ADP-ribose) polymerase (PARP). have previously identified cysteine (Cys) oxidation can be activity modulated via binding peroxiredoxin 1 (PRDX1). PRDX1 reduces peroxides coordinates signaling actions...
Global engagement between schools and colleges of pharmacy in the United States Africa is increasing. For a balanced fruitful engagement, sensitivity towards cultural clinical needs people professionals African region critical. In this paper, we have divided discussion into Southern, East, Central, West Africa. General information about Africa, with unique aspects for individual subregions countries, will be introduced. Stereotypes misconceptions also discussed, along recommendations...
Introduction The COVID-19 pandemic impacted healthcare operations affecting many patients with chronic pain and substance use disorder. Our study aimed to evaluate the effects of on opioid disorder (OUD) medication prescribing practices within a large academic health system in southern California. Methods This retrospective cohort included who received prescription for opioids or therapy OUD between November 1, 2019 September 2020. date range was divided into five specific time periods...
Nitro fatty acids (NO2-FAs) are endogenously generated lipid signaling mediators from metabolic and inflammatory reactions between conjugated diene nitric oxide or nitrite-derived reactive species. NO2-FAs undergo reversible Michael addition with hyperreactive protein cysteine thiolates to induce posttranslational modifications that can impact function. Herein, we report a novel mechanism of action natural non-natural nitroalkenes structurally similar (E) 10-nitro-octadec-9-enoic acid...
Recommendations for global pharmacy collaborations are predominately derived from US institutions. This study utilized semi-structured interviews of collaborators to assess important partnership components. Interviewees stated personal connections and understanding each other’s programs/systems were key Additionally, indicate that mutual benefits between partners can exist without the requirement bidirectional exchange learning experiences, request value learners who culturally aware,...
Medication reconciliation is an important aspect of a patient's care process that ideally performed by clinical pharmacists. Despite literature supporting this in other patient populations, cystic fibrosis (CF) lacks research area. To address this, we designed retrospective, multi-centered, non-controlled, cross-sectional study at four CF Foundation-accredited centers the United States to evaluate medication for adult and pediatric patients documenting number home medications reconciled...
Introduction Enoxaparin is a widely used anticoagulant to prevent venous thromboembolism ( VTE ). A fixed dose recommended for prophylaxis. However, prophylactic doses of enoxaparin in low‐weight patients may be close the weight‐based dosing treatment. Objective To evaluate peak anti–factor Xa aFX a) levels receiving Methods Retrospective cohort adult weighing < 55 kg who were hospitalized at Loma Linda University Medical Center between January 2008 and February 2017. All received...
Apixaban is indicated for the prevention of ischemic stroke in non-valvular atrial fibrillation (NVAF), as well and treatment venous thromboembolism (VTE). Dose adjustment based on age, weight, serum creatinine NVAF, while there are no recommended criteria VTE. Such unconventional compared to other commonly used medications. The objective this manuscript critically analyze each apixaban dosing criterion its associated outcomes. PubMed articles from March 2013 2020 were selected with search...
Abstract The American College of Clinical Pharmacy (ACCP) supports the completion residency training as a prerequisite for direct patient care responsibilities. current supply pharmacy opportunities, however, does not match demand, causing many graduates to enter workforce directly after completing their school training. Many pharmacists may then desire transition into clinical position leveraging versatility Pharm.D. degree and expanding opportunities in profession. Without training, these...
While educators and librarians have long been concerned with developing undergraduates' ability to find credible sources, the abundance of unreliable information online has exponentially complicated situation. In a new curriculum for English Composition 1001 classes, first-year writing class at University Cincinnati, we developed ways engaging student experiences before beyond sessions address source analysis through active peer learning. Using an action research framework position ourselves...
Although it has previously been thought that serotonin reuptake inhibitors (SSRIs) increase seizure risk, recent evidence suggests the risk of seizures comes from an underlying deficiency in rather than pharmacologic treatment. This article reviews some theories on mechanisms behind seizures, and how antidepressant therapy, particularly SSRIs, could affect risk.
Objective: The purpose of this study was to evaluate the impact capacity-building short-term mission service trips Sierra Leone on local health education and perspectives. Methods: This a prospective, mixed-methods study. During three between June 2017 December 2019, professional students taught multiple locally selected patient care-related topics. Local staff completed knowledge questionnaires were surveyed or interviewed along with cultural competence missionaries. Mission team members...
Abstract Background Efficacy for prolonged infusion beta-lactam dosing schemes has been previously described, but there less focus on the safety of standard vs protocols beta-lactams. This study explored differences in adverse drug reactions (ADRs) reported beta-lactams between each these protocols. Methods A systematic review MEDLINE literature databases via PubMed was conducted and references were compiled. Articles compiled assessed with specific inclusion/exclusion criteria. We included...