About
Contact & Profiles
A5012881826
Research Areas
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Lysosomal Storage Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Immune cells in cancer
- Immune Response and Inflammation
Cornell University
2023
TMEM106B, a lysosomal transmembrane protein, has been closely associated with brain health. Recently, an intriguing link between TMEM106B and inflammation discovered, but how regulates is unknown. Here, we report that deficiency in mice leads to reduced microglia proliferation activation increased microglial apoptosis response demyelination. We also found increase pH decrease enzyme activities TMEM106B-deficient microglia. Furthermore, loss results significant the protein levels of TREM2,...
10.1126/sciadv.add2676
article
EN
cc-by-nc
Science Advances
2023-05-05
10.1007/s00401-023-02578-w
article
EN
Acta Neuropathologica
2023-04-30
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