Disease staging involves the assessment of disease severity or progression and is used for treatment selection. In diabetic retinopathy, using a wide area more desirable than that limited area. We investigated if deep learning artificial intelligence (AI) could be to grade retinopathy determine prognosis.The retrospective study analyzed 9,939 posterior pole photographs 2,740 patients with diabetes. Nonmydriatic 45° field color fundus were taken four fields in each eye annually at Jichi...

Biological effects of dietary isoflavones, such as daidzein and genistein are interest in preventive medicine. We estimated the intake isoflavones from records compared values with plasma concentrations urinary excretions Japanese middleaged women. The was 64.6 111.6μ mol/day/capita (16.4 30.1 mg/day/capita), respectively. mostly attributable to tofu, natto miso. median concentration 72.46 206.09 nmol/L, excretion 20.54μ mol/day for daidzein, 10.79 genistein, 15.74 equol 1.64...

We developed an unsupervised machine learning algorithm and applied it to big corneal parameters identify monitor keratoconus stages. A dataset of swept source optical coherence tomography (OCT) images 12,242 eyes acquired from SS-1000 CASIA OCT Imaging Systems in multiple centers across Japan was assembled. total 3,156 with valid Ectasia Status Index (ESI) between zero 100% were selected for the downstream analysis. Four hundred twenty topography, elevation, pachymetry (excluding ESI...

Aflibercept and brolucizumab, two anti-VEGF agents used as intravitreal injections in ophthalmology, differ significantly molecular weight (aflibercept-115 kDa brolucizumab-26 kDa). Using aqueous humor samples collected after drug administration, we measured performed a comparative analysis of pharmacokinetics half-lives these drugs the human eye. Since quantification monoclonal antibodies (mAbs) using antigen-antibody reactions, such ELISA, is influenced by endogenous ligands or anti-drug...

Abstract Time‐resolved fluoroimmunoassays (TR‐FIA), with europium labeled phytoestrogens as tracers, were developed for the quantitative measurement of genistein, daidzein and enterolactone in plasma urine purpose screening large populations studies on possible correlation between values biological fluids risk western diseases. The mean three determined by TR‐FIA similar to those obtained gas chromatography‐mass spectrometry (GC‐MS). urinary excretion levels total individual higher than...

To determine changes in multiple cytokine concentrations the anterior chamber during induction phase of ranibizumab treatment patients with neovascular age-related macular degeneration (AMD).This prospective study included 48 treatment-naïve AMD eyes who received three consecutive monthly injections at Japan Community Health Care Organization Tokyo Shinjuku Medical Center between November 2010 and August 2012. We collected ~0.2 mL aqueous humour before first third (2 months later)...

To investigate whether sub-Tenon injection of triamcinolone acetonide (STTA) combined with anti-vascular endothelial growth factor (VEGF) prolongs the recurrence intervals macular edema (ME) for chronic retinal vein occlusion (RVO) and to differences in intraocular inflammatory cytokines between good responders (GRs) non-responders (NRs). This retrospective, observational study involved 42 eyes patients ME due RVO who had received only anti-VEGF ≥ 1 year were transitioned combination...

Abstract Background This study reports the first cases of scleritis following intravitreal brolucizumab (IVBr) injection for nAMD, emphasizing need to be aware possibility IVBr injections. Case presentation 1. A 74-year-old Japanese man with nAMD complained conjunctivitis and decreased vision in right eye 8 days after his eighth injection. Examination revealed without anterior inflammation. Topical 0.1% betamethasone 0.3% gatifloxacin drops were started. The worsened 2 weeks became painful....

To evaluate correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1 (NF1), we examined ten cases NF1 using near-infrared reflectance imaging. Patients ranged from 4 to 39 years. The angle used for imaging was 55°. We counted the total number of abnormalities an area within a 55° centered on fovea nodules iris by slit-lamp examination. No positive correlation found patient (Spearman's rank coefficient ρ=0.117, P=0.7414). Choroidal tended...

This study aimed to evaluate the long-term (24-month) efficacy and safety of a modified treat-and-extend (mTAE) regimen aflibercept for macular edema (ME) due branch retinal vein occlusion (BRVO). was prospective multicenter intervention study. We evaluated 50 eyes in patients with ME BRVO enrolled between October 2016 September 2017. The received intravitreal (IVA) injections according mTAE 24 months. reports secondary endpoints best-corrected visual acuity (BCVA) central subfield thickness...

To assess the efficacy and safety of a modified treat-and-extend (mTAE) regimen aflibercept for macular edema (ME) due to branch retinal vein occlusion (BRVO). This prospective multicentre intervention study evaluated 50 eyes patients enrolled from October 2016 September 2017. The received intravitreal (IVA) injections on an mTAE total 12 months. main outcome measures were best-corrected visual acuity (BCVA) central subfield thickness (CST) at baseline BCVA CST 0.33 (0.27) 488 (171) µm (mean...

Antioxidative activity of isoflavones has not been shown in humans. Newly-developed isoflavone-rich soya hypocotyl tea contains about 12 mg per liter. 15 drinkers and 23 control young female students were randomly selected from volunteers, underwent physical examination, blood chemistry urinary analysis before after one month drinking. A three-day dietary record was taken each examination. The showed a lower level phosphatidylcholine hydroperoxide (PCOOH) phosphatidyl-ethanolamine (PEOOH)...

Abstract Purpose To develop an artificial intelligence (AI) model for estimating best-corrected visual acuity (BCVA) using horizontal and vertical optical coherence tomography (OCT) scans of various retinal diseases examine factors associated with its accuracy. Methods OCT images BCVA measurements from 2,700 (accrued 2004 to 2018 Atlantis, Triton; Topcon, Tokyo, Japan) 756 eyes 469 patients their were retrospectively analysed. For each eye, one scan in cross-line mode used. The GoogLeNet...

Purpose: We report the 2-year outcomes of intravitreal aflibercept (IVA) for exudative age-related macular degeneration (AMD) with good visual acuity (VA) and examine baseline factors associated outcome. Materials methods: This multicenter, prospective study evaluated 39 eyes (39 AMD patients) enrolled from August 2013 to 2014 at 12 24 months. Only patients initial best-corrected VA (BCVA) >0.3 logarithm minimum angle resolution (20/40 Snellen) were eligible. Three consecutive monthly IVA...

We aimed to construct a better model for predicting treatment outcomes of anti-vascular endothelial growth factor therapy neovascular age-related macular degeneration (nAMD) using the concentrations aqueous humour proteins at baseline and during treatment. From data 48 treatment-naïve nAMD eyes that received intravitreal ranibizumab pro re nata up 12 months, we used C-X-C motif chemokine ligand 1 (CXCL1), CXCL12, CXCL13, interferon-γ-induced protein 10, monocyte chemoattractant (MCP-1), C-C...

We present a case of tarsal tunnel syndrome caused by an amyloidoma arising from the talocalcaneal joint in 64-year-old man with long history haemodialysis. He presented numbness medial plantar area right foot without any antecedent trauma. The was minimal at rest but gradually worsened, causing difficulty, when walking. Paraesthesia on sole foot. A positive Tinel-like sign noted 2.5 cm below malleolus. Magnetic resonance imaging demonstrated round lesion, 1 diameter, calcaneus, which...

Pterygium is a fibrovascular proliferative disorder in which conjunctival tissue grows medially to cover the clear cornea. It well known that outdoor work situations with high light reflectivity enhances pterygium development. Surgical resection not always necessary for patients without visual disturbance or cosmetic complaint. A 63-year-old woman presented 5-year history of slow growing wing-shaped ocular surface lesion left eye. Her best corrected acuity was 1.2 right eye and .9 On...

Backgroud/Purpose: To report a case of retinal astrocytic hamartoma with vitreous hemorrhage and hair pin-like vessel adhering to posterior membrane. A 33-year-old man presented 5 times. Methods: Multimodal imaging, including fundus photography, fluorescein angiography, optical coherence tomography, B-mode ultrasonography. Results: imaging demonstrated novel that adhered the Conclusion: Some cases may be related structure abnormalities tumor vessels.