A5049117613- Mesenchymal stem cell research
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Chemokine receptors and signaling
- Molecular Junctions and Nanostructures
- Kruppel-like factors research
- Surface Chemistry and Catalysis
- Cancer-related gene regulation
- Musculoskeletal synovial abnormalities and treatments
- Cancer Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Force Microscopy Techniques and Applications
- Streptococcal Infections and Treatments
- Medical Imaging and Pathology Studies
- Chronic Lymphocytic Leukemia Research
- HER2/EGFR in Cancer Research
- Antimicrobial Resistance in Staphylococcus
- Systemic Sclerosis and Related Diseases
- Sarcoma Diagnosis and Treatment
- Hip disorders and treatments
Kobe University
2002-2025
Kobe Institute Of Computing
2024
Rheumatoid arthritis (RA) involves synovial tissue proliferation, inflammation, and angiogenesis, contributes to joint destruction. Angiogenesis is a key therapeutic target for the treatment of RA, Janus kinase (JAK) inhibitors have emerged as promising therapy. In this study, we compared inhibitory effects five JAK inhibitors, including tofacitinib (TOF), baricitinib, peficitinib, upadacitinib, filgotinib, on interleukin (IL)-6-induced inflammation in RA tissues. All effectively suppressed...
Abstract Background Novel therapeutic strategies for the healing of nonunion, which has serious effects on quality life patients, are needed. We evaluated effect local transplantation human stromal vascular fraction (SVF) cells fracture in a rat non-healing model and compared between freshly isolated (F) cryopreserved (C)-SVFs. Methods Non-healing was induced femur female immunodeficient rats (F344/N Jcl rnu/rnu) with cauterizing periosteum. Immediately after creation fracture, received F...
A reversible, orientational switching of subphthalocyanine molecules was observed with a scanning tunneling microscope. The asymmetric, polar adsorbed in an epitaxial array on copper (100) surface, initially its axial chlorine atom either upward or downward. After at negative bias the turn upside down, while all switched to orientation positive bias. This flip-flop molecular would lead information density ∼60 Tbit/cm2.
Abstract The adipose‐derived stromal vascular fraction (SVF) is composed of a heterogeneous mix stem cells (ADSCs), macrophages, pericytes, fibroblasts, blood, and other cells. Previous studies have found that the paracrine effects SVF may be therapeutic, but their role in osteoarthritis treatment remains unclear. This study aimed to investigate therapeutic effect on chondrocytes. Chondrocytes were seeded culture plates alone (control) or cocultured with ADSCs cell inserts. After 48 h...
Nucleation growth of a platinum porphyrin derivative adsorbed on Cu (100) surface was observed with scanning tunneling microscope. The molecule attached four di-tert-butylphenyl groups allowed equilibrium between diffusional gas phase and two-dimensional nuclei. To minimize the free energy for nucleation, registry molecules into kink sites resulted in formation nuclei singular, rectangular contours. Dependence conditions sample-tip bias voltages also presented.
The concept of anatomic restoration has garnered considerable interest in the form kinematically aligned total knee arthroplasty (KA-TKA). KA-TKAs have been reported to reproduce natural alignment and kinematics. However, few randomized controlled trials (RCTs) compared biomechanical outcomes long-term clinical KA-TKA with those mechanically TKA (MA-TKA). We aim investigate effects determine whether or MA-TKA is more appropriate for primary TKA.This trial will compare MA-TKA. Two hundred...
BACKGROUND:Periprosthetic joint infection is a difficult complication, especially in patients with rheumatoid arthritis. Life-threatening septic shock due to periprosthetic caused by group G streptococcus rare, and there have been few reports about its treatment. We describe successful case of sudden onset Streptococcus after revision total knee arthroplasty. CASE REPORT:A 61-year-old woman arthritis treated biological disease-modifying antirheumatic drugs for 12 years presented acute right...
Kinematically aligned-total knee arthroplasty (KA-TKA) has recently attracted significant interest because it delivers better clinical outcomes than mechanically aligned (MA)-TKA. However, the optimal preoperative factors that maximize effectiveness of KA-TKA remain controversial. Therefore, we aimed to determine are appropriate for and might benefit from modified KA-TKA, based on patient-reported outcome measures (PROMs). The relationships between postoperative satisfaction other variables...
<title>Abstract</title> Background The uncultured adipose-derived stromal vascular fraction (SVF), consisting of cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA), however, the mechanisms underlying its effects remain unclear. Therefore, this study investigated SVF on OA in a human–immunodeficient rat xenotransplantation model. Methods model was induced knees female immunodeficient rats by destabilization medial meniscus. Immediately...
Abstract Background : Novel therapeutic strategies for the healing of nonunion, which has serious effects on quality life patients, are needed. We evaluated effect local transplantation human stromal vascular fraction (SVF) cells fracture in a rat non-healing model and compared between freshly isolated (F) cryopreserved (C)-SVFs. Methods Nonhealing was induced femur female immunodeficient rats (F344/N Jcl rnu/rnu) with cauterizing periosteum. Immediately after creation fracture, received F...
Knee osteoarthritis with femoral and/or tibial extra-articular deformities makes total knee arthroplasty (TKA) technically difficult to perform, especially using intramedullary-based instrumentation systems. The Athena 3-dimensional (3-D) image matching software is effective for TKA an deformity, in case of a long-stem prosthesis or not available computer-assisted navigation systems.A 79-year-old woman presented right pain secondary progressive valgus deformity and gait disturbance. She had...
<h3>Background</h3> The JAK/STAT signaling pathways mediate the effects of many cytokines and growth factors related rheumatoid arthritis (RA). Tofacitinib is a novel oral JAK inhibitor it has demonstrated high efficacy in RA, even non-responder to anti-TNF treatment. Gliostatin/thymidine phosphorylase (GLS/TP) known have angiogenic arthritogenic activities. GLS/TP was expressed inflamed synovial tissues patients with RA. In cultured fibroblast-like synoviocytes (FLSs), expression found be...
Abstract Background: Novel therapeutic strategies for the healing of nonunion, which has serious effects on quality life patients, are needed. We evaluated effect local transplantation human stromal vascular fraction (SVF) cells fracture in a rat non-healing model and compared between freshly isolated (F) cryopreserved (C)-SVFs. Methods: Nonhealing was induced femur female immunodeficient rats (F344/N Jcl rnu/rnu) with cauterizing periosteum. Immediately after creation fracture, received F...