A5074956342- Radiation Therapy and Dosimetry
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Anesthesia and Neurotoxicity Research
- Epigenetics and DNA Methylation
- Advanced Radiotherapy Techniques
- Effects of Radiation Exposure
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Pregnancy and preeclampsia studies
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Advanced NMR Techniques and Applications
- Reproductive System and Pregnancy
- Genomics and Chromatin Dynamics
- Soybean genetics and cultivation
- Radiation Detection and Scintillator Technologies
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
University of Lausanne
2020-2024
University of California, Irvine
2017-2023
Radiation Oncology Institute
2023
Howard University
2014
Abstract Purpose: Recent data have shown that single-fraction irradiation delivered to the whole brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit neurocognitive deficits mice. This observation has important clinical implications for management invasive and treatment-resistant tumors involves relatively large volumes with high cytotoxic doses. Experimental Design: Therefore, we aimed at simultaneously investigating antitumor efficacy neuroprotective...
Preeclampsia is a disease of the mother, fetus and placenta, gaps in our understanding complex interactions among their pathways withheld successful treatment prevention. The placenta has key role pathogenesis terminal pathway characterized by exaggerated maternal systemic inflammation, generalized endothelial damage, hypertension proteinuria. This sine qua non preeclampsia may be triggered distinct underlying mechanisms that occur at early stages pregnancy induce different phenotypes. To...
Background Tumor hypoxia is a major cause of treatment resistance, especially to radiotherapy at conventional dose rate (CONV), and we wanted assess whether does alter tumor sensitivity FLASH. Methods We engrafted several types (glioblastoma – GBM, Head & Neck cancer, lung adenocarcinoma) subcutaneously in mice provide reliable rigorous way modulate oxygen supply via vascular clamping or carbogen breathing. irradiated tumors using single 20 Gy fraction either CONV FLASH, measured tension,...
Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed descendants. This transgenerational inheritance has significant implications for understanding disease etiology. Here we show that exposure of F0 mice the obesogen tributyltin (TBT) throughout pregnancy and lactation predisposes F4 male descendants obesity when dietary fat is increased. Analyses body fat, plasma hormone levels, visceral white adipose tissue DNA methylome transcriptome collectively...
PurposeUltra-high-dose-rate FLASH radiation therapy has been shown to minimize side effects of irradiation in various organs while keeping antitumor efficacy. This property, called the effect, caused enthusiasm oncology community because it opens opportunities for safe dose escalation and improved outcome. Here, we investigated impact ultra-high-dose-rate versus conventional-dose-rate (CONV) total body (TBI) on humanized models T-cell acute lymphoblastic leukemia (T-ALL) normal human...
The identification of genes that are differentially methylated in colorectal cancer (CRC) has potential value for both diagnostic and therapeutic interventions specifically high-risk populations such as African Americans (AAs). However, DNA methylation patterns CRC, especially AAs, have not been systematically explored remain poorly understood. Here, we performed methylome profiling to identify the status CpG islands within candidate involved critical pathways important initiation...
The capability of ultrahigh dose rate FLASH radiation therapy to generate the effect has opened possibility enhance therapeutic index therapy. contribution immune response frequently been hypothesized account for a certain fraction antitumor efficacy and tumor kill but yet be rigorously evaluated.
Abstract Radiation-induced cognitive dysfunction (RICD) is a progressive and debilitating health issue facing patients following cranial radiotherapy to control central nervous system cancers. There has been some success treating RICD in rodents using human neural stem cell (hNSC) transplantation, but the procedure invasive, requires immunosuppression, could cause other complications such as teratoma formation. Extracellular vesicles (EV) are nanoscale membrane-bound structures that contain...
FLASH-radiotherapy (FLASH-RT) is an emerging modality that uses ultra-high dose rates of radiation to enable curative doses the tumor while preserving normal tissue. The biological studies showed potential FLASH-RT revolutionize radiotherapy cancer treatments. However, complex basis not fully known yet.
The pervasiveness of deep space radiation remains a confounding factor for the transit humans through our solar system. Spacecraft shielding both protects astronauts but also contributes to absorbed dose galactic cosmic ray interactions that produce secondary particles. resultant biological effects drop minimum aluminum around 20 g/ cm2 increase with additional shielding. present work evaluates first time, impact pions on central nervous system functionality. fractional pion emanating from...
Human stem cell-derived extracellular vesicles (EV) provide many advantages over cell-based therapies for the treatment of functionally compromised tissue beds and organ sites. Here we sought to determine whether human embryonic cell (hESC)-derived EV could resolve in part, adverse late normal complications associated with exposure lung ionizing radiation. The hESC-derived were systemically administered mice via retro-orbital sinus explore potential therapeutic benefits following high...
Abstract Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed descendants. This transgenerational inheritance has significant implications for understanding disease etiology. The obesogen hypothesis proposes that exposure obesogenic chemicals lead increased adiposity, vivo . Here we show of F0 mice the tributyltin (TBT) throughout pregnancy and lactation predisposes F4 male descendants obesity when dietary fat is increased. Analyses body fat, plasma...
Abstract Tumor hypoxia is a major cause of resistance to cancer treatments and especially radiotherapy (RT) we wanted assess whether ultra-high dose rate FLASH RT could overcome this resistance. We engrafted tumor cells various origins subcutaneously in mice provide reliable rigorous way modulate oxygen supply via vascular clamping or carbogen breathing. irradiated tumors using single 20 Gy fraction at either conventional (CONV) dose-rate. Using multiple different subcutaneous models,...
Abstract Background: Several driver mutations have been discovered in colorectal cancer (CRC) progressions including KRAS and BRAF that has a practical significant therapeutic prognostic value. Sequencing technology advanced now provides tool for the discovery of novel mutations. In addition, sequencing technologies provide whole genome methylation analysis. Here, we performed exome (WES) analysis to elucidate involvement candidate genes pathway may effect carcinogenesis. Patients Methods:...
Abstract Background: The identification and validation of genes that are frequently methylated in CRC will have potential value for both diagnostic therapeutic implications. However, the DNA methylation patterns especially African Americans not been well investigated. Here we aimed to determine status CpG islands candidate critical pathways important initiation development CRC. Materials Methods: Genomic from 7 individuals (1 normal, 2 adenomas, 4 adenocarcinomas) was used global analysis...
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<div>AbstractPurpose:<p>Recent data have shown that single-fraction irradiation delivered to the whole brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit neurocognitive deficits mice. This observation has important clinical implications for management invasive and treatment-resistant tumors involves relatively large volumes with high cytotoxic doses.</p>Experimental Design:<p>Therefore, we aimed at simultaneously investigating...
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<p>Supplementary Figure 1: Tumor growth delay of U87 orthotopic GBM implanted in the striatum female Nude mice measured by contrast-enhanced Cone Beam CT</p>
<p>Supplementary Figure 1: Tumor growth delay of U87 orthotopic GBM implanted in the striatum female Nude mice measured by contrast-enhanced Cone Beam CT</p>