A5039280395- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Catalytic C–H Functionalization Methods
- Steroid Chemistry and Biochemistry
- Chemical synthesis and alkaloids
- Pharmacogenetics and Drug Metabolism
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Catalytic Reactions
- Hormonal Regulation and Hypertension
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Radical Photochemical Reactions
- Synthetic Organic Chemistry Methods
- Advanced Synthetic Organic Chemistry
- Organic Chemistry Cycloaddition Reactions
- Marine Sponges and Natural Products
- Oxidative Organic Chemistry Reactions
AstraZeneca (Sweden)
2024-2025
University of Oxford
2020-2023
Achieving single-step syntheses of a set related compounds divergently and selectively from common starting material affords substantial efficiency gains when compared with preparing those same by multiple individual syntheses. In order for this approach to be realized, complementary reagent systems must available; here, panel engineered P450BM3 enzymes is shown fulfill remit in the selective C–H hydroxylation cyclobutylamine derivatives at chemically unactivated sites. The oxidations can...
This article describes a robust and large-scale synthesis of the ketosteroid building block 11β-hydroxyandrosterone (2) from cheap readily available hydrocortisone (1). The initial discovery route, which was conducted on gram scale achieved 3–6% yield over eight steps, is also described. Key to route redesign incorporation two stereoselective steps setting desired 5α-H 3α-OH chiral centers optimization minimize chromatographic purification. process then at kilogram 21–28% four steps.
Two total syntheses are presented for trigoxyphins K and L, tricyclic terpenoids from Trigonostemon xyphophylloides. The first proceeds via electrophlic cyclization in A/C-ring substrates to close the B ring at C4–C5 then 1O2-mediated hydroxybutenolide formation trigoxyphin with Luche reduction leading K. second route develops tetralone expansion a B/C-ring intermediate that, by one-step O-demethylation–lactonization–isomerization, affords L following enolate oxygenation.
Abstract Kinetic resolution using biocatalysis has proven to be an excellent complementary technique traditional asymmetric catalysis for the production of enantioenriched compounds. Resolution oxidative enzymes produces valuable oxygenated structures use in synthetic route development. This Minireview focuses on which catalyse insertion oxygen atom into substrate and, so doing, can achieve kinetic resolution. The Baeyer–Villiger rearrangement, epoxidation, and hydroxylation are included,...