A5054393645- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Minimally Invasive Surgical Techniques
- Parathyroid Disorders and Treatments
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Vascular Tumors and Angiosarcomas
- Management of metastatic bone disease
- Cardiac tumors and thrombi
- Hernia repair and management
- Surgical Simulation and Training
- Medical Imaging and Pathology Studies
- Gastrointestinal Tumor Research and Treatment
- Eosinophilic Esophagitis
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Diverticular Disease and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Thyroid and Parathyroid Surgery
- Colorectal Cancer Screening and Detection
- Anorectal Disease Treatments and Outcomes
- Neuroendocrine Tumor Research Advances
St. Marien Hospital
2015-2024
Malteser Krankenhaus St. Anna
2009-2023
Folkwang University of the Arts
2023
Heidelberg University
2002-2021
University Hospital Heidelberg
2002-2021
University Medical Centre Mannheim
2001-2021
Marienkrankenhaus Hamburg
2007-2021
Diakonie Klinikum Jung-Stilling
2013
Chirurgische Universitätsklinik Heidelberg
1999-2009
Medizinische Fakultät Mannheim
2007-2009
Tumours ferment glucose to lactate even in the presence of oxygen (aerobic glycolysis; Warburg effect). The pentose phosphate pathway (PPP) allows conversion ribose for nucleic acid synthesis and degradation lactate. nonoxidative part PPP is controlled by transketolase enzyme reactions. We have detected upregulation a mutated transcript (TKTL1) human malignancies, whereas (TKT) transketolase-like-2 (TKTL2) transcripts were not upregulated. Strong TKTL1 protein expression was correlated...
Objective To evaluate positron emission tomography (PET) using 2-fluoro-2-deoxy-D-glucose (FDG) for clinical application in soft tissue sarcomas. Summary and Background Data FDG PET is a promising noninvasive method the preoperative assessment of sarcomas may complement radiologic tomography. Methods from 50 consecutive patients with 59 masses, either suspicious primary or locally recurrent sarcoma, were prospectively gathered. The semiquantitative uptake (standardized values [SUVs]) was...
To determine whether circular plastic wound edge protectors (CWEPs) significantly reduce the rate of surgical site infections (SSIs) in comparison to standard towels patients undergoing laparotomy.SSIs cause substantial morbidity, prolonged hospitalization, and costs remain one most frequent complications. CWEPs have been proposed as a measure incidence SSIs.In this randomized controlled, multicenter, 2-arm, parallel-group design, patient- observer-blinded trial open elective abdominal...
The objective of this study was to evaluate the prognostic significance preoperative positron emission tomography (PET) using 2-fluoro-2-deoxy-D-glucose (FDG) by calculating mean standardized uptake values (SUV) in patients with resectable soft tissue sarcomas (STS). FDG-PET might be used as an adjunctive tool (in addition biopsy and radiologic tomography) assessment STS. A total 74 adult STS underwent imaging calculation SUV. Clinicopathologic data SUV were analyzed for association clinical...
Objective To determine the extent of pre- and intraoperative hematogenic tumor cell dissemination in patients undergoing liver resection for metastatic colorectal cancer. Summary Background Data For with hepatic metastases cancer, is only potentially curative therapy. However, 38% to 53% develop extrahepatic recurrence, probably caused by cells disseminated before or during surgery not detected current staging systems. Methods Blood samples harvested before, during, after from 41 bone marrow...
We sought to evaluate the efficacy and safety data of a combination regimen using weekly irinotecan in with capecitabine concurrent radiotherapy (CapIri-RT) as neoadjuvant treatment rectal cancer phase-II trial. Patients clinical stages T3/4 Nx or N+ were recruited receive (50 mg m−2 weekly) (500 bid days 1–38) RT dose 50.4 Gy. Surgery was scheduled 4–6 weeks after completion chemoradiation. A total 36 patients (median age 62 years; m/f: 27:9) including three local recurrence enclosed onto...
Purpose To establish the feasibility and efficacy of capecitabine in combination with weekly irinotecan (CAPIRI) concurrent pelvic radiotherapy (RT) patients locally advanced rectal cancer. Patients Methods Nineteen cancer clinical stage T3-4, Nx received 50 mg/m 2 (days 1, 8, 15, 22, 29) two doses 1 through 38; dose level [DL] I, 500 bid; DL II, 625 bid) according to phase I methodology. Three-dimensional conformal RT was given a 50.4 Gy (45 + 5.4 Gy). Results On no dose-limiting toxicities...
Transanal endoscopic microsurgery (TEM) allows locally complete excision of rectal neoplasms and provides an alternative to conventional surgery for benign tumours. However, its role in the curative treatment invasive carcinoma is controversial. This paper examines results TEM compared with radical (RS) T1 cancer.51 patients tumours treated by RS, or local means were included. The following parameters evaluated: operating time, blood loss, hospital stay complications, as well recurrence rate...
The cysteine proteases cathepsin B (CTSB) and L (CTSL) have been implicated in tumor spread metastatic formation. In pancreatic adenocarcinoma, the role of these is not very well defined. To find out which cell types produce CTSB CTSL to evaluate prognostic impact proteases, 70 specimens from curatively resected patients with adenocarcinoma were examined by situ hybridization immunohisto-chemistry.Seventy ductal pancreas studied after R0 resection a follow-up at least 3 years. expression was...
The notion of articulation in surgery has been largely synonymous with robotics. ARTISENTIAL® instruments aim at bringing advanced to laparoscopy overcome challenges narrow anatomical spaces. In this paper, we present first single-center results a series low anterior resections, performed ARTISENTIAL®.Between September 2020 and August 2021, the Department Surgery, St. Marienkrankenhaus Siegen, Germany, patients cancer mid- rectum were prospectively enrolled pilot feasibility study evaluate...
In thyroid surgery early postoperative recurrent laryngeal nerve (RLN) dysfunction offers a sensitive measure of the quality operation. The aim this study was to analyse effect training in on rate functional disturbances RLN after resection.In 617 patients (median age 48 years, female male ratio 2.8:1) who underwent unilateral or bilateral resection, 1059 RLNs were subjected operative risk. Laryngoscopy performed before and 45 surgeons divided into three groups: group 1, specialist surgeons;...
Abstract Aim Anastomotic leakage remains a key factor for morbidity after colonic surgery. The aim of the study was to analyse outcome different therapeutical approaches. Method Of 1731 consecutive patients undergoing resection between 1998 and 2005 at our institution, 67 with anastomotic were identified from prospective database. A logistic regression model used determine factors which influenced therapeutic approach outcome. Results overall rate 3.5%. All re‐operated. anastomosis resected...
Since the turn of century, robotic-assisted colorectal surgery has been synonymous with da Vinci® robotic surgical system. We report in this study our first results sigmoid resection for diverticular disease using Senhance™ Surgical Robotic System, while introducing a standardized roadmap engaging arms. 12 patients underwent System. All four arms system were engaged during all procedures according to previously devised roadmap. A 4-trocar technique was used patients. Perioperative data,...