A5102027282- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Synthesis and Reactions of Organic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis of heterocyclic compounds
- Pediatric Urology and Nephrology Studies
- Metal complexes synthesis and properties
- Phenothiazines and Benzothiazines Synthesis and Activities
- COVID-19 Clinical Research Studies
- Chemical Reaction Mechanisms
- Kidney Stones and Urolithiasis Treatments
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Multicomponent Synthesis of Heterocycles
- Urological Disorders and Treatments
- Hemoglobin structure and function
- Sepsis Diagnosis and Treatment
- Synthesis and Reactivity of Heterocycles
- Protein Interaction Studies and Fluorescence Analysis
- Renal function and acid-base balance
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
Cairo University
2013-2025
Children Cancer Hospital
2021-2025
Tanta University
2023
Mansoura University
2019-2022
South Valley University
2018
Children's Medical Center
2013
Sohag University
2011
Zagazig University
1987
Human serum albumin (HSA) is the frontline antioxidant protein in blood with established anti-inflammatory and anticoagulation functions. Here, we report that COVID-19-induced oxidative stress inflicts structural damages to HSA linked mortality outcome critically ill patients. We recruited 39 patients who were followed up for a median of 12.5 days (1–35 days), among them 23 had died. Analyzing samples from healthy individuals (n=11), provide evidence neutrophils are major sources hydrogen...
The knöevenagel condensation of 3-phenyl-4-thioxo-2-thiazolidinone (1) with 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehydes 2a–d in refluxing glacial acetic acid or polyethylene glycol-400 (PEG-400) at room temperature without catalyst, afforded the corresponding 5-hetarylmethylene derivatives 3a–d. [4+2]Cycloaddition reaction compounds 3 N-arylmaleimides, acrylonitrile and ethyl acrylate thiopyrano[2,3-d]thiazole 5a–p. anticancer activity some newly synthesized was investigated against...
Inflammatory breast cancer (IBC) is a rare, but aggressive entity of carcinoma with rapid dermal lymphatic invasion in young females. It either poorly or misdiagnosed as mastitis because the absence distinct lump. Small extracellular vesicles (sEVs) circulating liquid biopsies are novel class minimally invasive diagnostic alternative to tissue biopsies. They modulate progression via shuttling their encapsulated cargo including microRNAs (miRNAs) into recipient cells trigger signaling induce...
COVID-19 severity and high in-hospital mortality are often associated with severe hypoxemia, hyperlactatemia, acidosis, yet the key players driving this association remain unclear. It is generally assumed that organ damage causes toxic but since neutrophil numbers in can exceed 80% of total circulating leukocytes, we asked if metabolic acidosis mediated by glycolytic neutrophils lung impaired oxygen delivery critically ill patients. Based on prospective outcome, patients were divided into...
Inflammatory breast cancer (IBC) is a rare yet aggressive variant, associated with poor prognosis. The major challenge for IBC misdiagnosis due to the lack of molecular biomarkers. We profiled dysregulated expression microRNAs (miRNAs) in primary samples and non-IBC tumors using human miRNA PCR array. discovered that 28 miRNAs were (10 upregulated, while 18 underexpressed) vs. tumors. identified 128 hub genes, which are putative targets differentially expressed modulate important biological...
The coordination behaviour of the quinoxaline ligand with N and O donation sites, derived from 3-(2-oxo-2-p-tolylethyl)quinoxalin-2(1H)-one (HL), towards some transition metal ions namely Mn(II), Fe(III), Co(II), Ni(II), Cu(II) Zn(II) are reported. complexes characterized based on elemental analyses, IR, 1 H NMR, solid reflectance, magnetic moment, molar conductance thermal analyses (TG, DTG DTA). ionization constants as well stability its chelates calculated spectrophotometrically at 25 o C...
Background: Acute myeloid leukemia (AML) is a set of Myeloproliferative neoplasms that are identified by excessive growth blasts and production abnormal blood cells. AML the most common type acute occurs in adults. In addition, progresses rapidly considered fatal disease. Thus, there an urgent need to find new targets for molecularly designed therapies. This study, we evaluated circulatory levels microRNA-29a-3p (miR-29a-3p) miR-92a-3p beside exploring expression pattern their target gene...
Abstract 4‐Amino‐3‐(methylthio)‐6‐R‐1,2,4‐triazin‐5(4 H )‐ones 6 – 10 react with anthranilic acid to yield the 1‐amino‐3‐R‐2 ‐ as ‐triazino[3,2‐ b ]quinazoline‐2,6(1 )‐diones 17 21 rather than expected ‐triazino[3,4‐ ][1,3,4]benzotriazepines 12 16 . Compounds were deaminated into compounds 22 26 Heating of N ‐benzylidene derivatives (27 31) also led formation extrusion benzonitrile.
A simple green method has been developed for the synthesis of a series new 3-phenyl-6-(substituted)-thiopyrano[2,3-d]thiazole-2,5,7(6H)-triones, 6-cyano-2-oxo-3-phenyl-thiopyrano[2,3-d]thiazoles, 3-phenyl-3,5,5a,11b-tetrahydro-2H,6H-chromeno-[4′,3′:4,5]thiopyrano[2,3-d]thiazole-2,6-dione and 5-amino-6-cyano-2-oxo-3-phenyl-3,7-dihydro-2H-thiopyrano[2,3-d]thiazoles via hetero-Diels–Alder reaction by conventional using lemon juice as natural acid. The structure all newly synthesized compounds...
Abstract Synthesis of several derivatives thieno[2,3‐ e ]‐1,2,4‐triazines has been achieved via the action phosphorus pentasulfide on 6‐vinyl‐ or 6‐acylmethyl‐5‐oxo‐1,2,4‐triazine derivatives. During these investigations interesting synthetically useful functions for in pyridine were observed, among which deamination certain N ‐amino heterocycles is unprecedented.
Abstract The action of hydrazine on 3,5‐dioxo‐4‐aryl‐2,3,4,5‐tetrahydro‐1,2,4‐triazines gave 4‐amino‐3,5‐dixo‐2,3,4,5‐tetrahydro‐1,2,4‐triazines. intermediates this reaction were isolated and shown to be α‐ketoacidhydra‐zide 4‐arylsemicarbazones not the α‐ketoanilidecarbohydrazones. realtive rates cyclization latter isomeric derivatives provide a support for proposed which in 3‐mercapto 3‐methylmercapto‐4‐aryl‐5‐oxo‐4,5‐dihydro‐1,2,4‐triazines with hydrazine.
Gardenia blue (GB) is a natural pigment widely used in textiles and food industries as an eco-friendly alternative to synthetic dyes owing its safety, biocompatibility chemical stability. Herein we demonstrated recyclable, reusable efficient catalysis system for the biosynthesis of GB from geniposide using [Formula: see text]-glucosidase embedded copper phosphate hybrid nanoflowers. In this study, promising text]-glucosidase-secreting actinomycete was isolated identified Streptomyces...
Abstract The addition of thiosemicarbazones 1 to α‐halo acids 2 is shown give 2‐hydrazino‐2‐thiazolin‐4‐ones 3 and not 3‐substituted 2‐imino‐3‐(methyleneimino)thiazolidin‐4‐ones 4 . independent synthesis 2‐thiazolin‐4‐one derivatives also described.
Abstract 3‐(Methyltio)‐6‐R‐1,2,4‐triazin‐5(2 H )‐ones 1 – 6 have been converted into the 3‐R‐2 ‐ as ‐tri‐azino[3,2‐ b ]quinazoline‐2,6(1 )‐diones 8 13 upon cyclocondensation with anthranilic acid. Reaction of 2‐methyl‐3‐(methylthio)‐6‐phenyl‐1,2,4‐triazin‐5(2 )‐one ( 23 ) acid gave 1‐methyl‐3‐phenyl‐2 ‐triazino[3,4‐ ]quinoazoline‐4,69 (1 )‐dione 29 via intermediate 26 . N ‐Methylanthranilic and 2 or 5 afforded 11‐methyl‐3‐R‐2 ‐triazino[3,2‐ ]quinazoline‐2,6(11 36 38 , respectively.
Abstract Seven compounds of a new class ionophores, acyclic monoxadiamides, were synthesized and tested for the potentiometric selectivity lithium ion, in polyvinyl chloride (PVC) membrane electrodes. Four different plasticizers studied: o ‐nitrophenyloctyl ether (NPOE), ‐nitrophenylphenyl (NPPE), ‐nitrophenylbutyl (NPBE), ‐nitrophenylbenzyl (NPBnE), as was addition trioctylphosphine oxide (TOPO). The ionophore ‐carboxyphenoxyacetic acid dimorpholide (Ig) exhibited sodium‐lithium...
Abstract The action of hydrazine on 2‐mercapto and 2‐alkylmercaptoquinazolin‐4‐ones is reinvestigated. structure the isolated products have been revised.