A5001508717- Angiogenesis and VEGF in Cancer
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- Electrochemical sensors and biosensors
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Proteoglycans and glycosaminoglycans research
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
Cairo University
2019-2021
National Research Centre
2021
The therapeutic potential of Musashi (MSI) RNA-binding proteins, important stemness-associated gene expression regulators, remains insufficiently understood in breast cancer. This study identifies the interplay between MSI protein expression, stem cell characteristics, radioresistance, invasiveness and migration. MSI-1, MSI-2 Notch pathway elements were investigated via quantitative polymerase chain reaction (qPCR) 19 triple-negative cancer samples. Measurements repeated MDA-MB-231 cells...
Inflammatory breast cancer (IBC) is a rare yet aggressive variant, associated with poor prognosis. The major challenge for IBC misdiagnosis due to the lack of molecular biomarkers. We profiled dysregulated expression microRNAs (miRNAs) in primary samples and non-IBC tumors using human miRNA PCR array. discovered that 28 miRNAs were (10 upregulated, while 18 underexpressed) vs. tumors. identified 128 hub genes, which are putative targets differentially expressed modulate important biological...
Triple-negative breast cancer (TNBC) is characterized by increased angiogenesis, metastasis, and poor survival. Dysregulation of the cell surface heparan sulfate proteoglycan signaling co-receptor Syndecan-1 linked to prognosis. To study its role in we silenced TNBC lines using a 3D human umbilical vein endothelial (HUVEC) co-culture system. siRNA depletion SUM-149, MDA-MB-468, MDA-MB-231 cells decreased HUVEC tubule network formation. Angiogenesis array revealed reduced VEGF-A tissue factor...