A5103025048- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Alzheimer's disease research and treatments
- Cancer Research and Treatments
- Microtubule and mitosis dynamics
- Chemical Synthesis and Analysis
- Amyotrophic Lateral Sclerosis Research
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- RNA Interference and Gene Delivery
- Carbon and Quantum Dots Applications
- Medical Imaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoacoustic and Ultrasonic Imaging
- Chemical Synthesis and Reactions
- Sulfur Compounds in Biology
- Functional Brain Connectivity Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Supramolecular Self-Assembly in Materials
Massachusetts General Hospital
2018-2024
Gordon Center for Medical Imaging
2018-2024
Harvard University
2018-2024
MGH Institute of Health Professions
2018
Athinoula A. Martinos Center for Biomedical Imaging
2018
Background: Near-infrared (NIR) phototheranostics provide promising noninvasive imaging and treatment for head neck squamous cell carcinoma (HNSCC), capitalizing on its adjacency to skin or mucosal surfaces. Activated by laser irradiation, targeted NIR fluorophores can selectively eradicate cancer cells, harnessing the power of synergistic photodynamic therapy photothermal therapy. However, there is a paucity bioprobes showing tumor-specific targeting effective phototheranosis without...
Platinum-based anticancer agents have revolutionized oncological treatments globally. However, their therapeutic efficacy is often accompanied by systemic toxicity. Carboplatin, recognized for its relatively lower toxicity profile than cisplatin, still presents off-target toxicities, including dose-dependent cardiotoxicity, neurotoxicity, and myelosuppression. In this study, we demonstrate a delivery strategy of carboplatin to mitigate leveraging the potential zwitterionic nanocarrier,...
Due to the deep tissue penetration and reduced scattering, NIR-II fluorescence imaging is advantageous over conventional visible NIR-I for detection of bone growth, metabolism, metastasis, other bone-related diseases. Bone-targeted heptamethine cyanine fluorophores were synthesized by substituting meso-carbon with a sulfur atom, resulting in bathochromic shift increased intensity. The physicochemical, optical, thermal stability newly bone-targeted NIR was performed aqueous solvents. Calcium...
Development of an integrated robotic chemistry system and customized software for the automated operation complete split-pool procedures.
Amyotrophic Lateral Sclerosis (ALS) is a neurological disorder, which impairs tongue function for speech and swallowing. A widely used Diffusion Tensor Imaging (DTI) analysis pipeline employed quantifying differences in fiber myoarchitecture between controls ALS patients. This uses both high-resolution magnetic resonance imaging (hMRI) DTI. hMRI to delineate muscles, while DTI provides indices reveal connectivity within muscles. The preliminary results using five two patients show...
It is poorly known how Aβ and tau accumulations associate at the spatiotemporal level in vivo human brain to impact cognitive changes older adults prior AD symptoms onset. In this study, we used a graph theory-based analysis characterize cortical patterns of deposits their relationship with Harvard Aging Brain Study (HABS) cohort. We found that temporal interlinked pathology display distinctive correlations associated early decline. Notably, observed baseline deposits—Thal amyloid phase...
Hepatobiliary and renal excretions are the two major in vivo elimination pathways, of which prediction is particularly important for optimization systemic and/or target‐site exposure new near‐infrared (NIR) fluorescent contrast agents. To characterize physicochemical descriptors associated with each clearance route, a compound library containing more than 760 NIR fluorophores analyzed systematically reviewed this study. Although there host biochemical physiological mechanisms that ultimately...
Amyotrophic Lateral Sclerosis (ALS) is a progressive and irreversible neurological disorder, which affects upper lower motor neurons in the cortex that control voluntary movements including speech swallowing. High-resolution MRI (hMRI) Diffusion Tensor Imaging (DTI) can provide non-invasive imaging of three-dimensional muscle anatomy fiber myoarchitecture such as orientation within human tongue, respectively. In this work, we aim to assess anatomical differences tongue using both methods by...
Abstract Background: Due to the deep tissue penetration and reduced scattering, NIR-II fluorescence imaging is advantageous over conventional visible NIR-I for detection of bone growth, metabolism, metastasis, other bone-related diseases. Methods: Here, we designed bone-targeted heptamethine cyanine fluorophores by substituting meso -carbon with a sulfur atom, resulting in bathochromic shift increased intensity, which together enables tail imaging. Results: The newly synthesized...