A5003419482- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Carbon and Quantum Dots Applications
- Iron Metabolism and Disorders
- Muscle and Compartmental Disorders
- Poisoning and overdose treatments
- Trace Elements in Health
- Cancer Research and Treatments
- Photodynamic Therapy Research Studies
- Cancer Mechanisms and Therapy
- Abdominal Surgery and Complications
- Membrane-based Ion Separation Techniques
- Acute Kidney Injury Research
- Ear Surgery and Otitis Media
- Advanced Computing and Algorithms
- Synthesis and biological activity
- Pharmacological Effects and Toxicity Studies
- Lung Cancer Research Studies
- Photoacoustic and Ultrasonic Imaging
- Amino Acid Enzymes and Metabolism
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Hearing, Cochlea, Tinnitus, Genetics
- Folate and B Vitamins Research
- Hemoglobinopathies and Related Disorders
Massachusetts General Hospital
2021-2025
Gordon Center for Medical Imaging
2021-2025
Harvard University
2021-2025
Ajou University
2020-2022
The strategy of structure-inherent tumor targeting (SITT) with cyanine-based fluorophores is receiving more attention because no chemical conjugation moieties required. However, the mechanism behind SITT has not yet been well explained. Here, it demonstrated that heptamethine-cyanine-based possess only targetability microenvironments without need for additional ligands but also second near-infrared spectral window (NIR-II) imaging capabilities, i.e., minimum scattering and ultralow...
Deferoxamine (DFO) is an FDA-approved iron-chelating agent which shows good therapeutic efficacy, however, its short blood half-life presents challenges such as the need for repeated injections or continuous infusions. Considering lifelong of chelating agents iron overload patients, a sustained-release formulation that can reduce number chelator administrations essential. Here, injectable hydrogel formulations prepared by integrating crosslinked hyaluronic acid into Pluronic F127 extended...
Acute kidney injury (AKI) increases the risk of in-hospital death, adds to expense care, and early chronic disease. AKI often follows an acute event such that timely treatment could ameliorate potentially reduce additional Despite therapeutic success dexamethasone in animal models, clinical trials have not demonstrated broad success. To improve safety efficacy for AKI, we developed characterized a novel, kidney-specific nanoparticle enabling specific within-kidney targeting proximal tubular...
Enormous efforts have been made to integrate various therapeutic interventions into multifunctional nanoplatforms, resulting in the advance of nanomedicine. Image-guided drug delivery plays a pivotal role this field by providing specific targeting as well image navigation for disease prognosis.
Platinum-based anticancer agents have revolutionized oncological treatments globally. However, their therapeutic efficacy is often accompanied by systemic toxicity. Carboplatin, recognized for its relatively lower toxicity profile than cisplatin, still presents off-target toxicities, including dose-dependent cardiotoxicity, neurotoxicity, and myelosuppression. In this study, we demonstrate a delivery strategy of carboplatin to mitigate leveraging the potential zwitterionic nanocarrier,...
Abstract Autodynamic cancer therapy possesses tremendous potential for enhancing therapeutic efficacy by initiating the treatment process autonomously within targeted cells. However, challenges related to biocompatibility and delivery have hindered its clinical translation owing induction of adverse effects cytotoxicity in healthy In this study, a novel approach auto‐initiated dynamic conjugating zwitterionic near‐infrared fluorophores cell‐penetrating peptide is proposed. This enables...
The use of ligand conjugation onto nanoparticle surfaces as an active targeting strategy has gained significant attention in the pursuit improving tumor‐specific delivery and retention. However, chemical moieties often induces alterations physicochemical properties nanoparticles, including size, conformation, charge‐to‐mass ratio, hydrophilicity/lipophilicity, resulting unexpected biodistribution pharmacokinetic profiles. Here, enhanced efficiency achieved by integrating cyclic...
<b><i>Introduction:</i></b> The aim of this study was to assess the biocompatibility several intra-tympanic (IT) drug delivery vehicles and compare hearing outcomes. <b><i>Materials Methods:</i></b> After acute acoustic trauma, rats were treated with IT 10 mg/mL dexamethasone phosphate (D) divided into following groups for delivery: saline + D (<i>n</i> = 15), hyaluronic acid (HA) 17), methoxy polyethylene...
Aim: To characterize the pharmacokinetics of deferoxamine-conjugated nanoparticles (DFO-NPs), a novel nanochelator for removing excess iron. Materials & methods: The DFO-NPs were evaluated in Sprague-Dawley rats at three doses (3.3, 10 and 30 μmol/kg) after intravenous subcutaneous administration. Results: exhibited biphasic concentration-time profile administration with short terminal half-life (2.0-3.2 h), dose-dependent clearance (0.111-0.179 l/h/kg), minimal tissue distribution exclusive...
The advancement of targeted drug delivery faces significant challenges for clinical translation, such as issues related to poor solubility, non-specific distribution, and limited bioavailability cancer theranostics. Notably, promising developments in near-infrared (NIR) imaging, particularly those centered around Indocyanine Green (ICG), hold the potential intraoperative tumor targeting. However, field medical imaging grapples with two persistent challenges: 1) non-targeted uptake 2)...
<b>Abstract ID 28591</b> <b>Poster Board 494</b> Tens of millions individuals suffer from either primary or secondary iron overload, which are associated with induced diabetes, liver cirrhosis, cardiac arrhythmias, and ultimately lethal heart failure. Patients typically treated chelation therapy including deferoxamine (DFO), deferiprone, deferasirox. While DFO has good therapeutic efficacy among three them, its short half-life mandates daily infusion for 8-10 hours. This inconvenience been...