A5020612324- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Biochemical Analysis and Sensing Techniques
- Molecular spectroscopy and chirality
- Neurological disorders and treatments
- Vagus Nerve Stimulation Research
- Olfactory and Sensory Function Studies
Philipps University of Marburg
2023-2025
Abstract Background We investigated the relationship of piriform cortex (PC) structural network centrality with drug resistance and epilepsy duration as markers sustained epileptic activity. Methods PCs were manually delineated on retrospectively collected 3D‐T1‐MRI images patients temporal lobe (TLE). Connectomes computed from diffusion MRI scans, including PC nodes. Betweenness (BC) node degree compared across drug‐resistant versus drug‐sensitive patients. Correlations metrics calculated....
Background In 2014, the ILAE introduced a new definition of epilepsy that allows some patients to be diagnosed earlier than under previously used definition. According old classification, diagnosis was made after second unprovoked seizure. The risk this 36% first aim study is investigate clinical impact on diagnosis, treatment, and short-term outcome. Methods From 2018 2021, adult admitted with epileptic seizure were prospectively included. Demographic data collected at baseline, 6 12 months...
Abstract Objective The aim of the study was to evaluate benefits morphometric magnetic resonance imaging (MRI) postprocessing in patients presenting with a first seizure and negative MRI results investigate these findings context clinical electroencephalographic data, recurrence rates, epilepsy diagnosis patients. Methods We retrospectively reviewed 97 scans unprovoked epileptic no evidence epileptogenic lesion on routine MRI. Morphometric Analysis Program (MAP; v2018), automated software,...
Dysregulation of stress-reactive neuroendocrine measures, as well subjective stress, have been found to worsen epilepsy. Transcutaneous vagus nerve stimulation (tVNS) is a relatively new treatment option for We were interested in its effect on the activity hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS) stress tiredness patients with temporal lobe epilepsy (TLE).Twenty (age 44 ± 11 years, 13 women) enrolled study. They free seizures more than 1 year. All took...
Studies on risk factors for epilepsy and seizure recurrence after a first are usually based the old definition of with need two unprovoked seizures. The current allows diagnosis treatment if is >60%. We evaluate decisions, related to application new epilepsy.Data 629 patients were analyzed investigate changes decisions revised epilepsy. used binary logistic regression impact multiple influencing like electroencephalogram (EEG) magnetic resonance imaging (MRI) results administration...
The risk of seizure recurrence after a first unprovoked epileptic is reported to be approximately 40%. Little known about the in elderly patients, who may at higher due an increased rate structural lesions, encephalopathy, subcortical arteriosclerotic encephalopathy or brain atrophy.