A5023539990- Cerebrospinal fluid and hydrocephalus
- Alzheimer's disease research and treatments
- Cardiovascular Health and Disease Prevention
- Barrier Structure and Function Studies
- Orthopaedic implants and arthroplasty
- Micro and Nano Robotics
- Research Data Management Practices
- Advanced Neuroimaging Techniques and Applications
- Eicosanoids and Hypertension Pharmacology
- Bioinformatics and Genomic Networks
- NMR spectroscopy and applications
- Scientific Computing and Data Management
- Modeling and Simulation Systems
- Injection Molding Process and Properties
- Numerical Methods and Algorithms
- Electrohydrodynamics and Fluid Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Distributed and Parallel Computing Systems
- Nonlinear Dynamics and Pattern Formation
- Polymer Foaming and Composites
- Anesthesia and Neurotoxicity Research
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Polymer Nanocomposites and Properties
Simula Research Laboratory
2018-2019
University of Southampton
2015-2018
Computer science offers a large set of tools for prototyping, writing, running, testing, validating, sharing and reproducing results; however, computational lags behind. In the best case, authors may provide their source code as compressed archive they feel confident research is reproducible. But this not exactly true. James Buckheit David Donoho proposed more than two decades ago that an article about results advertising, scholarship. The actual scholarship full software environment, code,...
Alzheimer's Disease (AD) is the most common form of dementia and to date there no cure or efficient prophylaxis. The cognitive decline correlates with accumulation amyloid-β (Aβ) in walls capillaries arteries. Our group has demonstrated that interstitial fluid Aβ are eliminated from brain along basement membranes arteries, intramural periarterial drainage (IPAD) pathway. With advancing age arteriosclerosis, stiffness arterial walls, this pathway fails its function accumulates In study we...
The accumulation of soluble and insoluble amyloid-beta (A-beta) in the brain indicates failure elimination A-beta from with age Alzheimer's disease. There is a variety mechanisms for brain. They include action microglia enzymes together receptor-mediated absorption into blood periarterial lymphatic drainage A-beta. Although possesses no conventional lymphatics, experimental studies have shown that fluid solutes, such as A-beta, are eliminated along 100 nm wide basement membranes walls...
The mechanisms behind waste clearance from deep within the parenchyma of brain remain unclear to this date. Experimental evidence has shown that one pathway for clearance, termed intramural periarterial drainage (IPAD), is rapid interstitial fluid (ISF) via basement membranes (BM) smooth muscle cells (SMC) cerebral arteries and its failure closely associated with pathology Alzheimer's disease (AD). We have previously arterial pulsations heart beat are not strong enough drive clearance. Here...
Finite-differences methods such as the Lax-Wendroff method (LW) are commonly used to solve 1D models of blood flow. These for flow and lumen area useful in disease research, hypertension atherosclerosis, where pressure good indicators presence disease. Despite popularity LW equations, no implementation a solver these equations has been published made publicly available. This leads reimplementation same within different research groups makes verification results more difficult. The Vascular...
This package implements the 1D blood flow equations (Olufsen et al., 2000) using finite element framework FEniCS (Alnaes 2015).The provides tools for modelling through a network of arteries by solving approximation cross-sectional area and rate each artery.
Delivery of therapy-loaded nanoparticles (NP) via inhalation is an innovative technology shown to successfully reduce heart failure in mice, improving the efficiency drug delivery, and reducing adverse side effects. However, how exactly therapeutic NP are distributed absorbed by tissue remains poorly understood, accelerating this humans a major challenge. Working towards overcoming problem we developed open-source finite element model myocardial perfusion based on porous media, where...
Delivery of therapy-loaded nanoparticles (NP) via inhalation is an innovative technology shown to successfully reduce heart failure in mice, improving the efficiency drug delivery, and reducing adverse side effects.However, how exactly therapeutic NP are distributed absorbed by tissue remains poorly understood, accelerating this humans a major challenge.Working towards overcoming problem we developed open-source finite element model myocardial perfusion based on porous media, where perfused...