A5102814600- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Antimicrobial Peptides and Activities
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Rabies epidemiology and control
- Nanoplatforms for cancer theranostics
- Gastrointestinal Tumor Research and Treatment
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Bacterial Identification and Susceptibility Testing
- Milk Quality and Mastitis in Dairy Cows
- Mosquito-borne diseases and control
- Retinoids in leukemia and cellular processes
- Microbial infections and disease research
- Cannabis and Cannabinoid Research
- Gastrointestinal disorders and treatments
- Monoclonal and Polyclonal Antibodies Research
- Cytomegalovirus and herpesvirus research
- Vector-borne infectious diseases
- Infectious Encephalopathies and Encephalitis
- Bacterial biofilms and quorum sensing
- Immunotherapy and Immune Responses
- Synthesis of Organic Compounds
- Cancer Immunotherapy and Biomarkers
Jeonbuk National University
2003-2025
Chungnam National University
2021-2025
Animal and Plant Quarantine Agency
2020
Inje University
2010-2011
Catholic University of Korea
2002
Antibody-recruiting molecules (ARMs) have emerged as a promising strategy for enhancing immune responses against pathogens and cancer cells. In this study, we developed novel class of antibacterial ARMs utilizing siderophores, small iron-chelating compounds, targeting motifs. Siderophores naturally exhibit high specificity bacterial due to their role in iron acquisition, making them ideal candidates selective targeting. We identified potent ARM, GNP3, comprising MECAM, siderophore mimetic,...
Pembrolizumab, an immune checkpoint inhibitor (ICI) targeting the programmed cell death protein 1 (PD-1) receptor on T cells, enhances system's ability to recognize and attack cancer cells. However, immune-related adverse events (irAEs) may arise, necessitating careful monitoring during treatment. Here, we present case of a 47-year-old woman who developed multiple irAEs following pembrolizumab therapy. Initially diagnosed with Stage IIIB non-small lung cancer, she underwent chemotherapy...
ABSTRACT Outer membrane protein A (OmpA) plays a vital role in the interactions between Acinetobacter baumannii and host cells. Autophagy is defense mechanism that hinders intracellular replication of bacteria, thereby safeguarding cells against microbial infections. While it has been observed A. triggers cellular autophagy, precise its virulence OmpA this process remains uncertain. In study, we investigated effects (AbOmpA) on autophagy explored underlying molecular mechanisms. We found...
Bacterial infections are a significant cause of illness and death in different animals. However, these bacterial could be source human disease or if pathogenic bacteria present companion This study aimed to investigate the prevalence associated with site cats Republic Korea. For this purpose, samples were collected from skin/ear, urine, respiratory, diarrheal stool origins obtained between 2018 2019 seven laboratories centers participating Korean Veterinary Antimicrobial Resistance...
A comparative study of the photodynamic and antioxidant activities methyl pheophorbide-a (MPa, 1) its transition metal(II) complexes (2-5) is described. Four metal (palladium(II): 2, zinc(II): 3, cobalt(II): 4 copper(II): 5) MPa were prepared by reaction between corresponding 1, respectively, characterized <TEX>$^1H$</TEX>-NMR UV-vis spectroscopic mass spectrometric analyses. In vitro results show a therapy (PDT) efficacy with A549 cells might be attributed to heavy atom effect MPa. Among...
The emergence of bacterial infections in companion animals is a growing concern as humans can also be infected through the transmission pathogenic bacteria. Because there have been few studies conducted on animals, extent and significance prevalence veterinary practices remain unknown. This first nationwide surveillance report aimed at elucidating pattern associated isolated bacteria from dogs Korea. Bacterial isolates were collected seven different laboratories participating Korean...
To date, many groups focused on the development of new PS to afford selective photo-dynamic effect through a photoirradiation results in genera-tion singlet oxygen destroy tumour cells. Chlorins are second-generation PSs and good candidates for PDT account long wavelength absorption within photodynamic window (650 - 800 nm)
A simple and efficient synthetic route for making purpurin-18-N-aminoimides is described. The purpurin-18-Naminoimides are obtained by treatment of purpurin-18 methyl ester with various amines. These new compounds have long wavelength absorptions in the range 706 - 711 nm. In preliminary screening, shown promising photosensitizing activity cancer cell vitro study photodynamic therapy.
Quorum sensing of Acinetobacter nosocomialis for cell-to-cell communication produces N-3-hydroxy dodecanoyl-DL-homoserine lactone (OH-dDHL) by an AnoR/I two-component system. However, OH-dDHL-driven apoptotic mechanisms in hosts have not been clearly defined. Here, we investigated the induction apoptosis signaling pathways bone marrow-derived macrophages treated with synthetic OH-dDHL. Moreover, quorum-sensing system virulence regulation was evaluated vivo using wild-type and anoI-deletion...
Abstract Substrate (I) is obtained from chlorophyll paste by known procedures.
Scrub typhus is an acute, febrile disease of humans that caused by Orentia Tsutsugamushi. It transmitted through the bite chiggers. The spectrum clinical severity for scrub ranges from mild to sever e with fatal complication such as meningoencephalitis, pneumonitis, myocarditis. Severe pulmonary involvement e.g. acute respiratory distress syndrome(ARDS) and meningoencephalitis have rarely been obseved since introduction specific antibiotic therapy. We experienced a case manifested ARDS...