Abstract Purpose Resistance and adverse consequences of albendazole (ABZ) in treating trichinellosis urged demand for secure effective new drugs. The current study aimed to assess the effect chitosan-coated lipid nano-combination with miltefosine (MFS) experimental murine evaluating pathological immunological changes trichinellosis. Materials Methods One hundred twenty Swiss albino mice were divided into six groups. Each group was subdivided a b subgroups based on scarification time, which...

Abstract The breakthrough infection following COVID-19 vaccination has been a subject of concern recently. Evidence suggests that vaccine efficacy diminishes over time due to multiple factors related the host, and vaccine. Coinfection with other pathogens was claimed earlier as contributing cause for this phenomenon. Hence, we aimed stratify association post-COVID-19 coinfection Toxoplasma gondii ( T. ) its impact on disease severity. This cross-sectional study included 330...

Abstract Background Toxoplasma gondii ( T. ) and Helicobacter pylori H. are among the most prevalent foodborne parasitic bacterial infections worldwide. However, concurrent impact of coinfection on gastric pathology has yet to be studied in depth. The effect generally either adds a synergetic or antagonistic impact; we aimed current work assess progression pylori- associated reporting virulent strains. study was conducted 82 patients complaining persistent gastrointestinal symptoms with...

Abstract Background TORCH infections during pregnancy significantly impact neonatal and maternal mortality rates worldwide. This study aimed to gather baseline serological data for pregnant women's immunological status infection determine if definite pathogens ( cytomegalovirus , rubella virus, Herpes simplex virus) were associated with Toxoplasma infection, improve prenatal care provide appropriate control strategies. Methodology Blood samples gathered from 210 women attending Al Zagazig...

Abstract In the past decade, interest has significantly increased regarding medicinal and nutritional benefits of pomegranate (Punica granatum) peel. This study examined effects using peel extract (PGE) alone in combination with albendazole (ABZ) on ultrastructural immunological changes cystic echinococcosis laboratory-infected mice. Results revealed that smallest hydatid cyst size weight (0.48 ± 0.47mm, 0.17 0.18 gm) highest drug efficacy (56.2%) was detected PGE + ABZ group, which also...

Despite being the initial choice for treating toxoplasmosis, sulfadiazine and pyrimethamine have limited effectiveness in eliminating infection were linked to a variety of adverse effects. Therefore, search new effective therapeutic strategies against toxoplasmosis is still required. The current work first research assess efficacy spiramycin-loaded maltodextrin nanoparticles (SPM-loaded MNPs) as novel alternative drug therapy murine model. Fifty laboratory-bred Swiss albino mice divided into...

Background: Determination of the prevalence human toxocariasis is a priority considering sustained developmental goals WHO by 2030 and recent climatic changes. Objective: To detect seroprevalence among eosinophilic children in Shibin El Kom, Menoufia Governorate, Egypt. Subjects Methods: The study included 300 randomly selected for whom stool analysis was performed. Ninety-six positive other parasitic infections were excluded from to avoid cross-reactivity. remaining 204 with negative...

Background: Until now, there is no available satisfactory vaccine against human toxoplasmosis and the current medications have adverse side effects so search for prophylactic strategies mandatory. Objectives: To evaluate immunoprotection activity of immunogenic antigen as Toxoplasma gondii Surface Antigen 1 (SAG1) combined with maltodextrin nanoparticles (MNPs) toxoplasmosis. A secondary objective to assess most efficient route administration, intranasal (IN) or intradermal (ID). Materials...

Abstract Echinococcus granulosus (sensu lato), a cestode that is endemic in Egypt, causes cystic echinococcosis (CE), significant but neglected zoonotic disease prevalent throughout the world. Infected hydatid cysts are classified as fertile or non-fertile based on presence of protoscoleces; nevertheless, mechanism CE remains unknown. The study aimed to assess whether granzyme B (GrB) expression and CD4 + /CD8 could be related induction cysts. A total fifty-eight individuals diagnosed with...

Background; Autism spectrum disorders (ASD), are a range of mental neurodevelopmental type.More than three billion human hosts estimated to be affected by the protozoan parasite Toxoplasma gondii, which is intracellular pathogen with particular preference for central nervous system (CNS).Accumulating evidence suggests that latent chronic toxoplasmosis contributes triggering and progression many neurological psychiatric disorders, however link prevalence in ASD not clear.Objective; The...

Background: Currently, getting rid of schistosomiasis, which is classified as tropical ignored parasitic disease and endemic in Egypt, a national goal.Objectives: Our work was constructed on detection Schistosoma mansoni (S. mansoni) among school children using multi-stage survey Menoufia Governorate, Egypt known to be for the disease.Methodology; Formol ether concentration technique applied golden test stool samples compared Kato-katz procedure, IHA, FDA (Fast dot ELISA antigen detection)...