A5022023527- Pancreatic and Hepatic Oncology Research
- Pulmonary Hypertension Research and Treatments
- HER2/EGFR in Cancer Research
- Methane Hydrates and Related Phenomena
- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac Arrhythmias and Treatments
- Advanced Biosensing Techniques and Applications
- Esophageal Cancer Research and Treatment
- Image and Video Quality Assessment
- Neural Networks and Applications
- Lymphoma Diagnosis and Treatment
- Soft Robotics and Applications
- Video Coding and Compression Technologies
- Histone Deacetylase Inhibitors Research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Geological Studies and Exploration
- Protein Tyrosine Phosphatases
- Hemostasis and retained surgical items
- Retinal and Macular Surgery
- Cancer Diagnosis and Treatment
- Control Systems and Identification
- ATP Synthase and ATPases Research
Nippon Shinyaku (Japan)
2016-2025
University of Toyama
2020-2024
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
2023-2024
Kawasaki University of Medical Welfare
2021-2024
Kurume University
2024
Kyoto University
2019
The University of Tokyo
2012-2018
Shikoku Cancer Center
2016-2018
Association for the Development of Earthquake Prediction
2018
Hokkaido University
1995-2018
Background Treatment options for inoperable chronic thromboembolic pulmonary hypertension (CTEPH) remain limited. Selexipag, an oral selective IP prostacyclin receptor agonist approved arterial hypertension, is a potential treatment option CTEPH. Methods In this multicentre, randomised, double-blind, placebo-controlled study, 78 Japanese patients with CTEPH or persistent/recurrent after endarterectomy and/or balloon angioplasty were randomly assigned to receive placebo selexipag. The primary...
Background: Pulmonary hypertension (PH) is a fatal disease characterized by pulmonary artery (PA) remodeling, elevated PA pressure and right ventricular (RV) failure. It has been previously demonstrated that treatment with Rho-kinase inhibitor, fasudil, ameliorates PH in animal models. Here, whether combination therapy fasudil sildenafil further rats was examined. Methods Results: induced Sprague-Dawley the use of single subcutaneous monocrotaline (MCT) injection, which caused RV systolic...
Summary Many clinical research studies evaluate a time‐to‐event outcome, illustrate survival functions, and conventionally report estimated hazard ratios to express the magnitude of treatment effect when comparing between groups. However, it may not be straightforward interpret ratio clinically statistically proportional hazards assumption is invalid. In some recent papers published in journals, use restricted mean time (RMST) or τ ‐year discussed as one alternative summary measures for...
Background: Selexipag, an oral prostacyclin (PGI2) receptor agonist, is approved for adult patients with pulmonary arterial hypertension (PAH). This study evaluated the efficacy and safety of selexipag Japanese pediatric PAH.
Abstract Cause-of-death mortality forecasting, a key topic in public health and actuarial science, is challenging task due to the difficulty of modeling that accounts for dependencies among causes death. While several cause-of-death models have been proposed address this difficulty, little attention has paid improving their predictive performance. Recently, purely data-driven approaches using tensor decomposition methods introduced modeling, demonstrating strong out-of-sample performance...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by fibrofatty changes of the ventricle, arrhythmias, and sudden death. Though ARVC currently regarded as a disease desmosome, desmosomal gene mutations have been identified only in half patients, suggesting involvement other associated mechanisms. Rho-kinase signaling involved regulation intracellular transport organizes cytoskeletal filaments, which supports protein complex at myocardial cell-cell junctions. Here, we...
Background/Aim: There have been many studies on skeletal muscle depletion before surgery, and is a known risk factor for poor prognosis. However, reports the association between changes in mass prognosis after surgery pancreatic cancer are very few. Patients Methods: The data of 137 patients who underwent pancreatectomy 2005 2022 were reviewed. Muscle areas measured at third lumbar vertebral level, index (SMI) reduction rates calculated. divided into two groups using receiver operating...
Purpose – To prevent malpractices, medical staff has adopted inventory time-outs and/or checklists. Accurate and maintenance of surgical instruments decreases the risk operating room miscounting malfunction. In our previous study, an individual management was accomplished using Radio Frequency Identification (RFID) tags. The purpose this paper is to evaluate a new method RFID-tagged instruments. Design/methodology/approach system used for 27 months in clinical areas. total, 13 study...
Background Human epidermal growth factor receptor 2 (HER2) testing of samples from recurrent or metastatic breast cancer is recommended by the 2013 update American Society Clinical Oncology/College Pathologists guidelines. Although cytological analysis can be applied to several types lesions, practical method for HER2 specimens yet resolved. We conducted immunohistochemical (IHC) staining in cell blocks (CBs) and compared results with those corresponding histological specimens. In cases...
HER2 testing for samples from recurrent or metastatic disease is recommended by the 2013 update of American Society Clinical Oncology/College Pathologists (ASCO/CAP) guidelines and cytological analysis can be applied to several types lesions. However, practical method assess breast cancer cytology specimens has yet resolved. Therefore, we conducted bright-field dual in situ hybridization (DISH) assay on cell blocks (CBs) prepared as a validation study before clinical use. CBs were tumor...
Compared to tumors of other organs, pancreatic cancer is highly aggressive; with one its biological features being that, despite a prominent fibrotic stroma, there remarkable infiltration tumor cells. This characteristic considered be the main reason for poor prognosis patients cancer. Therefore, in order elucidate factors that contribute this high invasiveness, selective invasion method was used establish four invasive subclones from six human cell lines. The results demonstrated two lines...
Lenvatinib is a first-line standard treatment for advanced hepatocellular carcinoma (HCC) with better anti-tumor effects than sorafenib, as shown by greater inhibition of the kinases fibroblast growth factor receptor and vascular endothelial (VEGF) receptor. This report describes patient HCC who experienced perforation small intestine 1 month after starting lenvatinib. likely had partial necrosis metastasis to before lenvatinib treatment, subsequent ischemic changes leading intestine....
Immune checkpoint inhibitors can induce immune-related adverse events in various organs, thus careful observation is required.
The 106-Gb/s PAM4 operation of four DMLs in the 1.3-μm CWDM range demonstrated < 2.0 dB TDECQ after 5-km transmission. Clear eye openings and BER below KP4-FEC limit (2.2 × 10 −4 ) were achieved even 10-km