A5051718283- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Malaria Research and Control
- Drug Transport and Resistance Mechanisms
- Research in Social Sciences
- Education, Healthcare and Sociology Research
- Urologic and reproductive health conditions
- Antimicrobial Peptides and Activities
- Organ and Tissue Transplantation Research
- Heat shock proteins research
- RNA Interference and Gene Delivery
- Sphingolipid Metabolism and Signaling
- MicroRNA in disease regulation
- Diet and metabolism studies
- Social Work Education and Practice
- thermodynamics and calorimetric analyses
- Cancer Research and Treatments
- Digital Mental Health Interventions
- Tissue Engineering and Regenerative Medicine
- Glycosylation and Glycoproteins Research
- Viral Infectious Diseases and Gene Expression in Insects
- Urinary and Genital Oncology Studies
University of Oslo
2008-2022
Norwegian Institute of Public Health
2022
National Institute of Allergy and Infectious Diseases
2015
National Institutes of Health
2015
Oslo University Hospital
2008-2012
HistoGenetics (United States)
2012
Malaria is an infectious disease caused by parasites of several Plasmodium spp. Cerebral malaria (CM) a common form severe resulting in nearly 700,000 deaths each year Africa alone. At present, there no adjunctive therapy for CM. Although the mechanisms underlying pathogenesis CM are incompletely understood, it likely that both intrinsic features parasite and human host's immune response contribute to disease. The kinase mammalian target rapamycin (mTOR) central regulator responses, drugs...
LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we demonstrate that intratumoral treatment LTX-315 resulted in a complete regression and systemic immune response rat fibrosarcoma model. The was T-cell dependent, also abscopal effect as demonstrated by of distal non-treated lesions. Significant infiltration CD8+ T cells observed both treated lesions, shown immunohistochemical flow cytometric analysis. rapidly killed vitro lytic mode action followed...
Mesenchymal stromal cells (MSC) have important immunomodulatory properties, they inhibit T lymphocyte allo-activation and been used to treat graft-versus-host disease. How MSC exert their immunosuppressive functions is not completely understood but species specific mechanisms implicated. In this study we investigated the for rat mediated inhibition of proliferation secretion inflammatory cytokines in response allogeneic mitogenic stimuli vitro. inhibited mixed reactions mitogen with similar...
Abstract Immunity to Plasmodium falciparum malaria is naturally acquired in individuals living malaria-endemic areas of Africa. Abs play a key role mediating this immunity; however, the acquisition components Ab immunity, long-lived plasma cells and memory B (MBCs), remarkably inefficient, requiring years exposure. Although classical MBCs (CD19+/CD20+/CD21+/CD27+/CD10−) are gradually response natural infection, exposure P. also results large expansion what we have termed atypical...
Mesenchymal stromal cells (MSC) have important immunomodulatory effects that can be exploited in the clinical setting, e.g. patients suffering from graft-versus-host disease after allogeneic stem cell transplantation. In an experimental animal model, cultures of rat T lymphocytes were stimulated vitro either with mitogen Concanavalin A or irradiated mixed lymphocyte reactions, latter to simulate allo-immunogenic activation transplanted vivo. This study investigated inhibitory bone...
ABSTRACT GVHD causes extensive morbidity and mortality in patients who receive alloHCT. Predictive reliable markers for are currently lacking but required to improve the safety accessibility of We present an experimental rat model myeloablative total body irradiation fully mismatched major minor histoincompatible, T cell-depleted BMT, followed by delayed infusion donor lymphocytes. This treatment, contrast marrow transplantation alone, resulted severe aGVHD 100% lethality within 2–6 weeks....
The use of bone grafting in orthopaedic surgery has increased dramatically recent years. However, the degree to which immune responses are important for survival allograft is not fully understood. In particular it remains unclear whether differences major histocompatibility complex (MHC) influence incorporation allografts and their subsequent biologic performance.Therefore, we asked isolated mismatch MHC antigens deep frozen long-term causes (1) reactions, these reactions have any effect on...
Background The major histocompatibility complex (MHC) is the most important genomic region that contributes to risk of graft versus host disease (GVHD) after haematopoietic stem cell transplantation. Matching MHC class I and II genes essential for success However, contains additional also contribute developing acute GVHD. It difficult identify these by genetic association studies alone due linkage disequilibrium in this region. Therefore, we aimed other involved pathophysiology GVHD mRNA...
Natural killer cells are able to recognize and kill target according differences in MHC class I expression. In rodents, the Ly49 receptors primarily responsible for this differentiation. We previously described cloning of a novel C-type lectin-like receptor, KLRH1, encoded NK complex adjacent genes expressed by subsets NKT cells. influence on selection KLRH1(+) congenic strains suggested that KLRH1 may have an ligand, although we were unable identify any such ligand. study, used sensitive...
Background. Graft-versus-host disease (GVHD) is the most serious complication after allogeneic hematopoietic stem-cell transplantation. A human skin explant assay has been used to predict risk of GVHD in patients by histological grading graft-versus-host reactions (GVHR). New molecular markers GVHR might help further increase predictive value assay. Methods. rat developed aid identifying potential novel markers. Results. In inbred strains were observed explants co-cultured with lymphocytes...
Mesenchymal stromal cells (MSC) can be used to treat graft-versus-host disease (GVHD) caused by allogeneic stem cell transplantation (allo-SCT). The effectiveness of this therapy has been variable in clinical trials and experimental animal models. In study, we investigated the ability bone marrow (BM)-derived MSC alleviate GVHD an rat model allo-SCT using two different combinations major histocompatibility complex (MHC) mismatch with survival as primary endpoint. Recipient rats received...
Allogeneic hematopoietic cell transplantation (alloHCT) extends the lives of thousands patients who would otherwise succumb to malignancies such as leukemias and lymphomas, aplastic anemia disorders immune system. In alloHCT, different types mediate beneficial graft-versus-tumor (GvT) effects, regulate detrimental graft-versus-host disease (GvHD), are required for protection against infections. Today, 'good' (GvT effector cells memory conferring protection) cannot be easily separated from...
Abstract Malaria is an infectious disease caused by parasites of the Plasmodium spp. In endemic areas, in approximately 1% cases, almost exclusively young children, malaria becomes severe resulting nearly seven hundred thousand deaths each year Africa alone. Cerebral (CM) a common form and one for which we have no effective adjunctive therapy. The kinase, mammalian target rapamycin (mTOR), through its regulation cellular metabolism, central regulator immune responses drugs that inhibit mTOR...
e21046 Background: LTX-315 (Oncopore) is a chemically designed cationic nonapeptide derived from natural host defensive CAP, bovine lactoferricin (LfcinB) in development for local treatment of tumours. Earlier studies have demonstrated that A20 lymphomas and CT26WT carcinomas with immunocompetent mice resulted tumour regression. Re-challenge tumor cells the cured animals showed long- term protection was induced against tumor. Methods: In current experiments we investigated if also can same...