A5091438434- Malaria Research and Control
- HIV Research and Treatment
- Drug Transport and Resistance Mechanisms
- Mosquito-borne diseases and control
- Complement system in diseases
- Aquaculture disease management and microbiota
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxoplasma gondii Research Studies
- Sphingolipid Metabolism and Signaling
- Immunotherapy and Immune Responses
National Institute of Allergy and Infectious Diseases
2015-2020
National Institutes of Health
2015-2020
Immungenetics (Germany)
2020
Malaria-specific antibody responses are short lived in children, leaving them susceptible to repeated bouts of febrile malaria. The cellular and molecular mechanisms underlying this apparent immune deficiency poorly understood. Recently, T follicular helper (Tfh) cells have been shown play a critical role generating long-lived responses. We show that Malian children resting PD-1+CXCR5+CD4+ Tfh circulation resemble germinal center phenotypically functionally. Within population,...
Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that results in thousands deaths each year, mostly African children. The vivo mechanisms underlying this fatal condition are not entirely understood. Using the animal model experimental cerebral (ECM), we sought mechanistic insights into pathogenesis CM. Fatal disease was associated with alterations tight junction proteins, vascular breakdown meninges / parenchyma, edema, and ultimately neuronal cell death...
Significance Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection in African children despite effective antimalarial treatment. Once signs neurologic disease have commenced, there no adjunctive treatment for CM, and overall mortality remains high. Thus, that arrests promotes healing the late stages urgently needed. Here we report, an animal model glutamine analog 6-diazo-5-oxo-L-norleucine (DON) therapy even when initiated after infected animals show neurological...
Malaria is an infectious disease caused by parasites of several Plasmodium spp. Cerebral malaria (CM) a common form severe resulting in nearly 700,000 deaths each year Africa alone. At present, there no adjunctive therapy for CM. Although the mechanisms underlying pathogenesis CM are incompletely understood, it likely that both intrinsic features parasite and human host's immune response contribute to disease. The kinase mammalian target rapamycin (mTOR) central regulator responses, drugs...
BACKGROUNDMalaria pathogenicity is determined, in part, by the adherence of Plasmodium falciparum-infected erythrocytes to microvasculature mediated via specific interactions between P. falciparum erythrocyte membrane protein (PfEMP1) variant domains and host endothelial receptors. Naturally acquired antibodies against PfEMP1 variants can play an important role clinical protection malaria.METHODSWe evaluated IgG responses a repertoire CIDR domain determine rate order variant-specific...
ApiAP2 transcription factor PBANKA_011210 is a novel Plasmodium virulence that blocks induction of host’s immune response.
Abstract Cerebral malaria (CM) is the deadliest form of severe Plasmodium infections. Currently, we have limited understanding mechanisms by which parasites induce CM. The mouse model CM, experimental CM (ECM), induced infection with rodent parasite, berghei ANKA ( Pb ANKA) has been extensively used to study pathophysiology Recent genomic analyses revealed that coding regions and closely related NK65 NK65), does not cause ECM, differ in only 21 single nucleotide polymorphysims (SNPs). Thus,...
ABSTRACT Malaria pathogenicity is determined, in part, by the adherence of Plasmodium falciparum infected erythrocytes to microvasculature mediated via specific interactions between PfEMP1 variant domains host endothelial receptors. Naturally acquired antibodies against variants can play an important role clinical protection malaria. We evaluated IgG responses a repertoire CIDR domain determine rate and order variant-specific antibody acquisition their association with febrile malaria...
Abstract Malaria is an infectious disease caused by parasites of the Plasmodium spp. In endemic areas, in approximately 1% cases, almost exclusively young children, malaria becomes severe resulting nearly seven hundred thousand deaths each year Africa alone. Cerebral (CM) a common form and one for which we have no effective adjunctive therapy. The kinase, mammalian target rapamycin (mTOR), through its regulation cellular metabolism, central regulator immune responses drugs that inhibit mTOR...
Abstract The Apetela2 (AP2) family of transcription factors is a major regulator Plasmodium parasite gene expression. Twenty seven members this have been identified since their discovery in 2005. However, our understanding which AP2 regulate key features biology incomplete. Here we describe the impact single nucleotide polymorphism (SNP) active site protein, PBANKA_011210, on outcome infection mice. berghei Anka (PbA), only rodent that causes experimental cerebral malaria (ECM), codes for...