A5067906614- Monoclonal and Polyclonal Antibodies Research
- Advanced Fluorescence Microscopy Techniques
- Advanced Biosensing Techniques and Applications
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Alzheimer's disease research and treatments
- Chemokine receptors and signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
University of York
2020-2022
A major hallmark of Alzheimer's disease is the misfolding and aggregation amyloid- β peptide (Aβ). While early research pointed towards large fibrillar- plaque-like aggregates as being most toxic species, recent evidence now implicates small soluble Aβ oligomers orders magnitude more harmful. Techniques capable characterizing oligomer stoichiometry assembly are thus critical for a deeper understanding earliest stages neurodegeneration rationally testing next-generation inhibitors....
The ability of tumors to establish a pro-tumorigenic microenvironment is an important point investigation in the search for new therapeutics. Tumors form microenvironments part by "education" immune cells attracted via chemotactic axes such as that CCR5-CCL5. Further, CCR5 upregulation cancer cells, coupled with its association features drug resistance and metastasis, has suggested therapeutic target. However, several conformational "pools" being reported, phenotypic investigations must be...
Summary The ability of tumors to establish a pro-tumorigenic microenvironment is becoming an important point investigation in the search for new therapeutics. Tumors form microenvironments part by ‘education’ immune cells attracted via chemotactic axes such as that CCR5-CCL5. Further, CCR5 upregulation cancer cells, coupled with its association features drug-resistance and metastasis, has suggested target therapeutic inhibition. However, several conformational “pools” being reported,...
The ability of tumors to establish a pro-tumorigenic microenvironment is becoming an important point investigation in the search for new therapeutics. Tumors form microenvironments part by “education” immune cells attracted via chemotactic axes such as that CCR5-CCL5. Further, CCR5 upregulation cancer cells, coupled with its association features drug-resistance and metastasis, has suggested target therapeutic inhibition. However, several conformational ‘pools’ being reported, phenotypic...