A5023871069- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Dementia and Cognitive Impairment Research
University of Edinburgh
2023-2024
Alzheimer Scotland
2023-2024
QIMR Berghofer Medical Research Institute
2024
NHS Lothian
2023-2024
Cohort (United Kingdom)
2024
Frailty may represent a modifiable risk factor for dementia, but the direction of that association remains uncertain. We investigated frailty trajectories in years preceding dementia onset using data from 23,672 participants (242,760 person-years follow-up, 2,906 cases incident dementia) across four cohort studies United States and Kingdom. Bayesian non-linear models revealed accelerations 4-9 before dementia. Among whose time between measurement exceeded prodromal period, remained...
Frailty is a complex trait. Twin studies and high-powered Genome Wide Association Studies conducted in the UK Biobank have demonstrated strong genetic basis of frailty. The present study utilized summary statistics from Study on Index to create test predictive power frailty polygenic risk scores (PRS) two independent samples - Lothian Birth Cohort 1936 (LBC1936) English Longitudinal Ageing (ELSA) aged 67-84 years. Multiple regression models were built PRS at five time points. significantly...
Importance An accessible marker of both biological age and dementia risk is crucial to advancing prevention treatment strategies. Although frailty a candidate for that role, the nature relationship between not well understood. Objective To clarify temporal incident by investigating trajectories in years preceding onset. Design, Setting, Participants Participant data came from 4 prospective cohort studies: English Longitudinal Study Ageing, Health Retirement Study, Rush Memory Aging Project,...
Frailty is a multifaceted clinical state associated with accelerated aging and adverse health outcomes. Informed etiological models of frailty hold promise for producing widespread improvements across the population. currently measured using aggregate scores, which obscure pathways that are only relevant to subcomponents frailty. Therefore, we performed first multivariate genome-wide association study latent genetic architecture between 30 deficits, identified 408 genomic risk loci. Our...
Abstract Frailty is a complex trait. Twin studies and recent Genome-Wide Association Studies have demonstrated strong genetic basis of frailty but there remains lack exploring prediction Frailty. Previous work has shown that single polygenic predictor – represented by score - predicts Frailty, measured via the index, in independent samples within United Kingdom. We extended this work, using multi-polygenic (MPS) approach to increase predictive power. Predictor variables twenty-six scores...
Abstract Background Frailty is a complex clinical state that associated with poorer health outcomes and increased dementia risk in older adults. It routinely measured using the Index, which proportional score based on number of ‘deficits’ an individual has. Whilst such measures are useful for assessment, aggregation highly heterogeneous deficit profiles genetic studies may obscure important insights into underlying biology frailty. Method We used Genomic Structural Equation Modelling to...
Frailty is a complex trait. Twin studies and high-powered Genome Wide Association Study (GWAS) conducted in the UK Biobank have demonstrated strong genetic basis of frailty. The present study utilized summary statistics from this GWAS to create test predictive power frailty polygenic risk scores (PRS) two independent samples - Lothian Birth Cohort 1936 (LBC1936) English Longitudinal Ageing (ELSA) aged 67-84 years. Multiple regression models were built PRS at five time points. significantly...